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Structural Genomics, Part B
 
 

Structural Genomics, Part B, 1st Edition

 
Structural Genomics, Part B, 1st Edition,Andrzej Joachimiak,ISBN9780123744425
 
 
 

A Joachimiak   

Academic Press

9780123744425

9780080922386

112

229 X 152

This volume presents step-by-step techniques for researchers that will predict the structure and potential function of proteins by identifying its coding sequence.

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Key Features

Key Features
*Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy

* Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Structural Genomics, Part B, 1st Edition

Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community



 
 
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