Key Features
*The first comprehensive volume covering the breadth of the topic
*The latest advancements that lead to novel directions in the study of red cells
*An informative discussion of red cells as they relate to the essential oxygen-carrying component of the body
Description
This compendium provides a concise and up-to-date assessment of critical recent issues related to erythroid biology. Developmental, epigenetic, methodological, biochemical, and clinical aspects are integrated to provide a powerful overview of their interrelationships and importance to the generation of the red cell. The excitement generated by these novel observations and the anticipation of future directions in studies of the red cell is a highlight of this volume.
Readership
developmental biologists, molecular biologists, stem cell biologists, pediatric and adult hematologists
Red Cell Development, 1st Edition
1 Ontogeny of Erythropoiesis in the Mammalian Embryo
Kathleen McGrath and James Palis
2 The Erythroblastic Island
Deepa Manwani and James J Bieker
3 Epigenetic Control of Complex Loci During Erythropoiesis
Ryan J. Wozniak and Emery H. Bresnick
4 The Role of the Epigenetic Signal, DNA Methylation, in Gene Regulation During Erythroid Development
Gordon D. Ginder, Merlin N. Gnanapragasam, and Omar Y. Mian
5 Three-dimensional Organisation of Gene Expression in Erythroid Cells
Wouter de Laat, Petra Klous, Jurgen Kooren, Daan Noordermeer, Robert-Jan Palstra, Marieke Simonis, Erik Splinter, Frank Grosveld
6. Iron Homeostasis and Erythropoiesis
Diedra M. Wrighting and Nancy C. Andrews
7. The Effects of Nitric Oxide on Red Cell Development and Phenotype
Vladan P. Èokiæ and Alan N. Schechter
8. Diamond Blackfan Anemia: A Disorder of Red Blood Cell Development
Steven. R. Ellis and Jeffrey M. Lipton
