Advances in Immunology

Advances in Immunology, 1st Edition

Advances in Immunology, 1st Edition,Frederick Alt,ISBN9780123743244

Advances in Immunology

F Alt   

Academic Press




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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.


Immunologists and infectious disease specialists, cell biologists and hematologists

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

View additional works by Frederick W. Alt

Advances in Immunology, 1st Edition

  • Contributors to Volume 97
    • Publisher Summary
  • T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other
    • Abstract
    • 1 Introduction
    • 2 TCR Signaling Leading to Actin Cytoskeletal Remodeling
    • 3 Cytoskeletal Control of IS Formation
    • 4 Regulation of TCR‐Mediated MTOC Polarization
    • 5 F‐Actin‐Mediated Regulation of Integrins
    • 6 Cytoskeletal Dynamics and Cell Migration
    • 7 Conclusion
  • HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
    • Abstract
    • 1 Introduction
    • 2 Expression and Function of HLA‐DQ Transgenes in Mice
    • 3 HLA‐DQ Transgenic Mice as Models for Human Allergies
    • 4 Expression and Function of HLA‐DR Transgenic Mice
    • 5 HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis‐Derived Proteins as Humans
    • 6 Collagen‐Induced Arthritis—Model for Human Rheumatoid Arthritis
    • 7 Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis
    • 8 Spontaneous Models for Human Type I Diabetes
    • 9 Experimental Autoimmune Myasthenia Gravis
    • 10 HLA and Gluten Sensitivity‐Celiac Disease and Dermatitis herpetiformis
    • 11 Relapsing Polychondritis
    • 12 Spontaneous Autoimmune Myocarditis
    • 13 Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007)
    • 14 Experimental Autoimmune Uveitis (Adapted fromPennesi et al., 2003)
    • 15 Bacterial Superantigens and Toxic Shock Syndrome
    • 16 Concluding Remarks
  • Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule
    • Abstract
    • 1 Introduction
    • 2 Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease
    • 3 Role of Zn in the Immune Response
    • 4 Role of Zn in Mast Cells
    • 5 Zn Signaling
    • 6 Conclusion and Future Prospects
    • Acknowledgements
  • The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses
    • Abstract
    • 1 Introduction
    • 2 Structure, Ligands, and Expression of the SLAM‐Family Receptors
    • 3 The SLAM‐Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus
    • 4 The SLAM‐Associated Protein
    • 5 The Protective Role of SAP in X‐Linked Lympho‐Proliferative Disease
    • 6 The SAP‐Related Single SH2‐Domain Proteins EAT‐2A and EAT‐2B
    • 7 The SLAM‐Family Receptors in NK Cell Responses
    • 8 The Role of the SLAM‐Family in Lymphoid Cells
    • 9 The Role of the SLAM‐Family on Nonlymphoid Cells
    • 10 Concluding Remarks
  • Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes
    • Abstract
    • 1 Introduction
    • 2 A Minimal Signaling Kit Couples to Proximal Transducer Enzymes
    • 3 Signal Initiation: BCR Clusters with an Open Conformation
    • 4 SLP-65: A Gateway to Intracellular Signaling Pathways
    • 5 Dynamic Regulation of the BCR-Triggered Ca2+ Response
    • 6 Mechanism and Function of BCR-Induced Ras Activation
    • 7 Concluding Remarks
  • Subject Index
    • Publisher Summary
  • Contents of Recent volumes
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