Multiscale Modeling of Developmental Systems

Multiscale Modeling of Developmental Systems, 1st Edition

Multiscale Modeling of Developmental Systems, 1st Edition,Gerald Schatten,Santiago Schnell,Philip Maini,Stuart A. Newman,Timothy Newman,ISBN9780123742537

Current Topics in Developmental Biology

Schatten   &   Schnell   &   Maini   &   Newman   &   Newman   

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Key Features

* Articles written by leading exponents in the field
* Provides techniques to address multiscale modeling
* Coverage includes a wide spectrum of modeling approaches
* Includes descriptions of the most recent advances in the field


Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.
This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds.


Graduate students and scientists in developmental biology, mathematical sciences, biomathematics, and general life sciences.

Gerald Schatten

Affiliations and Expertise

University of Pittsburgh School of Medicine, PA, U.S.A.

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Multiscale Modeling of Developmental Systems, 1st Edition

Chapter 1
Philip K. Maini, Stuart A. Newman, Timothy J. Newman and Santiago Schnell

Chapter 2
Models of biological pattern formation: from elementary steps to the organization of embryonic axes
Hans Meinhardt

Chapter 3
Robustness of embryonic spatial patterning in Drosophila melanogaster
David Umulis, Michael B. O’Connor and Hans G. Othmer

Chapter 4
Integrating morphogenesis with underlying mechanics and cell biology.
Lance A. Davidson

Chapter 5
The mechanisms underlying primitive streak formation in the chick embryo
Manli Chuai, Cornelis J Weijer

Chapter 6
Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formation
T. J. Newman

Chapter 7
Mathematical models for somite formation
Ruth E. Baker, Santiago Schnell and Philip K. Maini

Chapter 8
Coordinated Action of N-CAM, N-cadherin, EphA4 and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick
James A. Glazier, Ying Zhang, Maciej Swat, Benjamin Zaitlen, Santiago Schnell

Chapter 9
Branched organs: Mechanics of morphogenesis by multiple mechanisms
Sharon R Lubkin

Chapter 10
Multicellular sprouting during vasculogenesis
Andras Czirok, Evan A. Zamir, Andras Szabo and Charles D. Little

Chapter 11
Modelling lung branching morphogenesis
Takashi Miura

Chapter 12
Multiscale Models for Vertebrate Limb Development
Stuart A. Newman, Scott Christley, Tilmann Glimm, H.G.E. Hentschel, Bogdan Kazmierczak, Yong-Tao Zhang, Jianfeng Zhu and Mark Alber

Chapter 13
Tooth morphogenesis in vivo, in vitro and in silico
Isaac Salazar-Ciudad

Chapter 14
Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation
Michael Meyer-Hermann

Chapter 15
Cellular automata as microscopic models of cell migration in heterogeneous environments
H. Hatzikirou and A. Deutsch

Chapter 16
Multiscale modeling of biological pattern formation
Ramon Grima

Chapter 17
Relating Biophysical Properties Across Scales
Elijah Flenner, Francoise Marga, Adrian Neagu, Ioan Kosztin, Gabor Forgacs

Chapter 18
Complex Multicellular Systems and Immune Competition: New Paradigms Looking for a
Mathematical Theory
N. Bellomo, G. Forni
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