Key Features
Key Features
* The first comprehensive reference on the emerging field of Neuromodulation
* Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society
* Close to 100 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise.
* Over 1200 pages in splendid full color, richly illustrated
* Important areas of application include:
- control of chronic pain
- delivery of drugs to the nervous system via implanted devices
- control of epilepsy, Parkinson, etc.
- functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events
- stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs)
- overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces
* Appendices go into detail about different techniques, and provide an overview over the present manufactures and the devices they make.
* Support website with ancillary material and information about important developments in the field / clinical trials etc.
Description
Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs.
The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices.
All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.
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Readership
Basic scientists and academic clinicians in neuroscience, particularly neurophysiology, behavioral neuroscience, sensory neuroscience (including audiology, ophthalmology, and particularly pain), neuroanatomy, neurosurgery, neurological diseases, as well as physiologists in Cardiology, Gastroenterology, Urology.
Biomedical engineers
Clinical specialists: anesthesiology, neurosurgery, neurology, neurophysiology, cardiology, gastroenterology, urology and orthopedics
Neuromodulation, 1st Edition
Prolog (Joseph Pancrazio)
Glossary
I. Introduction (Krames, Peckham, Rezai)
1. What is Neuromodulation (Elliot Krames, Hunter Peckham, Ali Rezai)
2. Neuromodulation: A Historical Perspective (Philip Gildenberg)
3. Whom Do We Serve (Allen Dyer, Mary Pat Aardrup)
4. Challenges in Moving toward Product Development (Paul Meadows)
5. The Birth of an Industry (James Cavuoto)
6. The Beginning of Societies (Ross Davis)
7. Clinical Study Design (Dan Carr)
8. Psychological Evaluation for Patients Undergoing Implantable Technology (Daniel Doleys)
9. Neuromodulation: Ethical Considerations (Joseph Fins)
II. Fundamentals of Neuromodulation (Peckham, Rezai)
10. Anatomy of the Nervous System (Alan Bassbaum)
11. Physiology of the Nervous System (Patrick Senatus)
12. Brain Imaging and Neurocircuitry (Brian Kopell, Ali Rezai)
13. Plasticity of the Nervous System (Mike Merzenich & M. Kilgard)
14. Fundamentals of Electrical Stimulation (J. Thomas Mortimer)
15. Electrical Field Generation for Excitation and Inhibition (Warren Grill)
16. Bioelectrical Effects of Neural Stimulation/Mechanisms of Neural Stimulation (Robert Foreman, Rezai)
17. Fundamentals of Infusion Therapies (Robert Levy)
18. Neurotropic factors, Stem Cells, Gene Therapy, and Neuromodulation (Nick Boulis, Thais Federici, Jonathan Riley, Mike Kaplitt)
III. Biomedical Engineering Considerations (Warren Grill, Peckham)
19. Electrodes for the Neural Interface (Dustin Tyler)
20. Preservation of Cellular Function (Bill Shain)
21. Biomaterials for the Neural Interface (Doug McCreary)
22. Implantable Neural Stimulators (Hunter Peckham, Robert Strother)
23. Designing a Feed Back Neural/Machine Interface (John Donoghue)
24. Neuromodulation Implantable Devices: MRI Safety (Frank Shellock)
IV. Neuromodulation for Chronic Pain (Krames, Rezai)
25. Physiology and Pathophysiology of Pain: Targets for Neuromodulation (Andre Machado)
26. The Endogenous Neuromodulation System (Allan Basbaum, Frank Porreca)
27. Management Strategies for Chronic Pain (Rollin Gallagher)
A. Periphery and Spinal Cord Electrical Stimulation for Non-Visceral Pain (North, Barolat, Brian Simpson)
28. Transcutaneous Neural Stimluation: A Review (Howard Smith, Kathleen Sulka, Deirdre Walsh)
29. Mechanisms of Spinal Cord Stimulation for Pain (Bengt Linderoth, Robert Foreman)
30. Spinal Cord Stimulation for Spinal Pain Disorders: Outcomes and Cost Benefits Analysis (Richard North)
31. SCS for Peripheral Vascular Disorders (Svante Horsch)
32. SCS For Painful Neuropathies (Giancarlo Barolat)
33. SCS for CRPS (Joshua Prager)
34. Peripheral Nerve Stimulation For Painful Peripheral Neuralgia & CRPS (Michael Stanton-Hicks)
35. Peripheral Nerve Stimulation for Occipital Neuralgia and Headache (Richard Weiner, Ken Alo)
36. Subcutaneous Peripheral Nerve Stimulation (Teodor Goroszeniuk)
B. Infusional Therapies for Pain (Krames, Prager)
37. Relevant Anatomy for Spinal Delivery (Timothy Deer)
38. Intrathecal Opioid Analgesics for the Control of Pain (Elliot Krames, Mouchir Harb)
39. Non-Opioid Analgesics for the Control of Pain (Peter Staats)
40. Intrathecal Analgesic, Choice of Systems (Marshall Bedder)
41. Guidelines for the Use of Intrathecal Agents: Use of Polyanalgesia (Enrique Reig, David Abajon)
42. Issues of Compounding Intrathecal Agents (Richard Rauck, James North)
43. Intraventricular Delivery of Analgesics: How Does it Differ from Intrathecal Delivery? (Robert Levy)
C. Brain Stimulation for Pain (Katayama, Yves Keravel)
44. Deep Brain Stimulation for Pain (Tipu Aziz)
45. Deep Brain Stimulation of the Hypothalamus for Cluster Headache (Giavoanni Broggi)
46. Motor Cortex Stimulation for Pain (Yves Keravel, Nguyen)
V. Neuromodulation for Movement Disorders (Alim Benabid)
47. Movement Disorders: Anatomy, Physiology, Pathophysiology, and Disorders (Brian Kopell, Brad Hiner)
48. DBS for Parkinson's Disorder (Philip Starr)
49. DBS for Temor (Kelly Foote, Michael Oaken)
50. Infusion Therapies for Spasticity and Movement Disorders (Richard Penn)
51. DBS for Dystonia (Ron Alterman)
52. DBS for Tourettes Syndrome (Veerle Visser-Vandewalle)
VI. Neuromodulation for Epilepsy (Imad Najm, Joseph Smith)
53. Epilepsy: Anatomy, Physiology, Pathophysiology, and Disorders (David King-Stephens)
54. VNS for Epilepsy (Arun Amar)
55. DBS for Epilepsy (Gordon Baltuch)
56. Cerebellar Stimulation for Epilepsy (Ashwini Sharan)
57. Closed-loop Stimulation for Epilepsy (Joseph Smith)
VII. Neuromodulation for Psychiatric Disorders (Ben Greenberg, Rezai)
58. Psychiatric Disorders: Anatomy, Physiology, Pathophysiology, and Disorders (Ben Greenberg)
59. VNS and rTMS for Depression (Linda Carpenter)
60. DBS for Depression (Ali Rezai, Ben Greenberg)
61. DBS for OCD (Bart Nuttin)
62. Neuromodulation for Addictions (Bomin Sun)
VIII. Neuromodulation for Functional Restoration (Peckham)
63. Stimulation for the Return of Hearing (Blake Wilson)
64. Stimulation for the Return of Eyesight (Joseph Rizzo)
65. Stimulation for the Return of Function after Stroke (John Chae, Jayme Knutson, Lynne Sheffler)
66. Cortical Stimulation for Stroke Recovery (Robert Levy)
67. Stimulation for Return of Upper & Lower Extremity Function (Michael Keith, Keith Kilgore, Ron Triolo)
IX. Neurostimulation of Body Organs (Krames)
A. Cardiac (Krames)
68. Neuronal Control of the Heart (Robert Foreman)
69. Disorders of Pacing (Siegfried Eckert - Germany)
70. Pacemakers for Disorders of Pacing ? Past, Present, and Future (TBD)
71. Cardiac Defibrillators (Don Deyo)
72. Spinal Cord Stimulation for Refractory Angina (Mike DeJongste, Clas Mannheimer)
73. Neurostimulation for Hypertension, Heart Failure, and Arrhythmias (Marc Penn)
B. Gastrointestinal Krames
74. Abdominal Organs and Neuronal Control (Robert Foreman, Greenwood-Vanmeerveldt)
75. SCS for GI Painful Disorders (Leonardo Kapural)
76. Sacral Nerve Stimulation for Fecal Incontinence (Thomas Kenefick)
77. Gastric Stimulation for Obesity & Dysmotility Disorders (Cristian Sevcencu)
C. Genitourinary Rezai
78. Genitourinary Function and Nervous System Control (Firouz Daneshgari, William C. de Groat)
79. Sacral Nerve Root Stimulation for Painful Bladder Disorders (Dan Brookoff, Adnan Al-Kaisy)
80. Neurostimulation for Urinary Incontinence (Raymond Rackley)
X. Emerging Applications of Neuromodulation (mini chapters, 1000 words each)
81. DBS for Obesity (Alim Benabid, Chabards)
82. DBS for Blood Pressure Control (Erlick Pereira, Tipu Aziz)
83. Tinnitus (Brian Kopell, David Friedland)
84. Neuromodulation for Brain Injury (Nicholas Schiff)
85. Novel Neuromodulation Approaches for Alzheimer and Other Neurodegenerative Conditions (Roy Bakay)
86. Cortical Signal Recordings, Human Brain-Machine Interface, & Clinical Applications (Gerhard Friehs, Leigh Hochberg)
XI. Appendices
A. Surgical Techniques
1. DBS
2. Spinal Cord Stimulation
3. Peripheral Nerve Stimulation
4. Thecal Therapy
5. Vagal Nerve Stimulation
B. Present Manufacturers of Devices and Specs for:
1. Pain
2. Hearing
3. Deep Brain Stimulators
4. Pacing
5. Urostim
6. Gastrostim
