Chesley's Hypertensive Disorders in Pregnancy

Chesley's Hypertensive Disorders in Pregnancy, 4th Edition

Chesley's Hypertensive Disorders in Pregnancy, 4th Edition,Robert Taylor,James Roberts,F. Cunningham,Marshall Lindheimer,ISBN9780124078666

Taylor   &   Roberts   &   Cunningham   &   Lindheimer   

Academic Press




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Fourth edition of classic preeclampsia reference for OB/GYNs, nephrologists, and cardiologists

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Key Features

  • Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis
  • Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management
  • Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia
  • Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book


Chesley’s Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial.
The fourth edition of Chesley’s Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia.


Researchers and clinicians in OB/GYN, nephrology, and cardiology; as well as graduate students and post-doctoral fellows in physiology, renal, cardiovascular, and hypertension research.

Robert Taylor

Robert N. Taylor, MD, PhD is Vice Chair for Research in the Department of Obstetrics and Gynecology at Wake Forest School of Medicine. Previously, he was Professor of Obstetrics and Gynecology at Emory University and Director of the Center for Reproductive Sciences at the University of California, San Francisco (UCSF). Dr. Taylor received his undergraduate education at Stanford University and completed the combined MD-PhD program at Baylor College of Medicine. His graduate work on the molecular biology of estrogen action was performed under the supervision of Roy G. Smith, PhD and Bert W. O’Malley, MD. Dr. Taylor trained as a resident in Obstetrics and Gynecology and subsequently as a fellow in Reproductive at UCSF. He then completed a postdoctoral fellowship with Lewis T. (“Rusty”) Williams, MD, PhD in the Howard Hughes Medical Institute at UCSF, where he studied the regulation of placental angiogenesis by growth factors and their receptors. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist widely published in the areas of preeclampsia, embryonic implantation and endometriosis. Dr. Taylor serves on influential international, national and state executive committees including the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, several NIH Women’s Reproductive Health Research advisory boards, and the California Institute for Regenerative Medicine. He is a Past President of the Society for Gynecologic Investigation and honorary secretary of the World Endometriosis Society.

Affiliations and Expertise

Professor, Obstetrics & Gynecology, Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, NC, USA

James Roberts

Dr. James M. Roberts, MD is Professor of Obstetrics and Gynecology and Epidemiology and Clinical and Translational Research at the University of Pittsburgh. His research includes fundamental, clinical and health services approaches to the understanding and management of adverse pregnancy outcomes. He led an NIH RCT (10,000 women) of antioxidant vitamins to prevent preeclampsia. He has been the recipient of lifetime achievement awards by the International Society for the Study of Hypertension in Pregnancy, the SGI and the Preeclampsia Foundation Hope. He has served or serves on the editorial boards of journals including, Placenta, Journal of Clinical Endocrinology, Metabolism. Reproductive Sciences, Women’s Health Issues and Hypertension. He has been on scientific review boards of the NIH, the CIHR, the FDA and the March of Dimes. He was the chair of the NICHD Maternal Fetal Medicine Network from 1990 -1999 and is past president of the Perinatal Research Society, the North American Society for the Study of Hypertension in Pregnancy, the Society of Gynecological Investigation, and the International Society for the Study of Hypertension in Pregnancy. He was formally admitted to fellowship ad eundem of the Royal College of Obstetricians and Gynaecologists in September 2000. He has been elected to membership in the Institute of Medicine of the National Academy of Sciences. He has also received mentoring awards from the NICHD and the Society of Gynecological Investigation.

Affiliations and Expertise

Senior Scientist, Magee-Women’s Research Institute and Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences, and Epidemiology University of Pittsburgh, PA, USA

F. Cunningham

F. Gary Cunningham, MD is holder of the Miguel and Beatrice Distinguished Chair of Obstetrics and Gynecology at the University of Texas Southwestern Medical Center. He is also chair emeritus of the Department of Obstetrics and Gynecology, having served in that position for 22 years. Dr. Cunningham received his MD degree from the Louisiana State University School of Medicine and completed a residency in Obstetrics and Gynecology at Charity Hospital of New Orleans. Following this, he completed a fellowship in Maternal-Fetal Medicine at UT Southwestern and Parkland Hospital in Dallas, Texas. His early career was influenced by Dr. Jack Pritchard, and together they performed extensive clinical and laboratory research in preeclampsia and eclampsia, coagulopathies and other hematological complications of pregnancy, as well as a myriad of medical and surgical disorders complicating pregnancy. He has served as an examiner for the American Board of Obstetrics and Gynecology, served as tor for an NIH consensus conference, and is a member of the Society for Maternal-Fetal Medicine, Society for Gynecologic Investigation, and the American Gynecological and Obstetrical Society. Dr. Cunningham has served as senior editor of the 18th through 24th editions of Williams Obstetrics.

Affiliations and Expertise

Professor and Beatrice and Miguel Elias Distinguished Chair in Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, USA

Marshall Lindheimer


Dr. Marshall Lindheimer, a professor (emeritus) of Medicine, Obstetrics & Gynecology, and Clinical Pharmacology at the University of Chicago is a longtime admirer and was a longtime friend of the late Leon Chesley. Chief Editor of the second and third editions of this text and leader of the search for its current chief editor, Dr. Lindheimer prefers to be called “editor emeritus” despite continuing to comment and publish in the area of the hypertension and renal disease in pregnancy. His CV contains over 400 publications including a monograph, other edited texts, reviews, text chapters and articles devoted to both basic and clinical research. Boarded in Internal Medicine and Nephrology, he is the recipient of many awards and honors that include an honorary membership in the Society of Maternal Fetal Medicine and an ad eundem of the Royal College of Obstetrics and Gynecology London. He has received an Honoris Causa degree from Bern University, the Chesley award from the International Society for the Study of Hypertension in Pregnancy, the Belding Scribner Award from the American Society of Nephrology and the Joseph Bolivar DeLee Humanitarian award from the Board of Directors at Lying-in Hospital, Chicago. Both the National Kidney Foundation of Illinois and the Preeclampsia Foundation have honored him as well. Of note on his wall is a congratulatory letter from President Obama, recognizing his accomplishments in regard to the health of pregnant women and their unborn children.

Affiliations and Expertise

Professor Emeritus, Department of Obstetrics and Gynecology and Medicine, and the Committee on Clinical Pharmacology, The University of Chicago, IL, USA

Chesley's Hypertensive Disorders in Pregnancy, 4th Edition

1. Introduction, History, Controversies, and Definitions
Marshall D. Lindheimer, Robert Neal Taylor, Gary Cunningham and James M. Roberts
2. The Clinical Spectrum of Preeclampsia
Gary Cunningham, James M. Roberts and Robert Neal Taylor
3. Epidemiology of Pregnancy-Related Hypertension
Janet Rich-Edwards
4. Genetic Factors in the Etiology of Preeclampsia
Kenneth Ward
5. The Placenta in Normal Pregnancy and Preeclampsia
Susan Fisher
6. Angiogenesis and Preeclampsia
S. Ananth Karumanchi and Sarosh Rana
7. Metabolic Syndrome and Preeclampsia
Carl Hubel, James M. Roberts and Arun Jeyabalan
8. Immunology of Normal Pregnancy and Preeclampsia
Ian Sargent and Christopher Redman
9. Endothelial Cell Dysfunction and Oxidative Stress
Sandra T. Davidge and C de Groot
10. Animal Models
Joey Granger
11. Tests to Predict Preeclampsia
Agustin Conde-Agudelo and Roberto Romero
12. Prevention of Preeclampsia and Eclampsia
Baha Sibai
13. Cerebrovascular (Patho)Physiology in Preeclampsia/ Eclampsia
Gerda G. Zeeman and Marilyn J. Cipolla
14. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy
Sanjeev G. Shroff and Judith Hibbard
15. The Renin-Angiotensin Systems, their Autoantibodies, and Body Fluid Volume in Preeclampsia
Ralf Dechend and Babette LaMarca
16. The Kidney and Normal Pregnancy and Preeclampsia
Kirk Conrad, Isaac Stillman and Marshall D. Lindheimer
17. Platelets, Coagulation, and the Liver
Louise Kenny and Keith R. McCrae
18. Chronic Hypertension and Pregnancy
Phyllis August and Arun Jeyabalan
19. Antihypertensive Treatment
Jason Gari Umans and Edgardo Abalos
20. Management
James Alexander and Gary Cunningham

Quotes and reviews

Praise for the Fourth Edition:

"This book constitutes an indispensable update on preeclampsia, one of the most important and intriguing diseases of pregnancy. It covers the genetic, mechanistic, immunological and medical aspects of hypertension in pregnancy in a very comprehensive way. It is written clearly by world specialists in the subject, making it accessible to students, scientists and physicians as well."
- Daniel Vaiman, PhD, HDR, Head Team "Genetics, Epigenetics, Physiopathology of Reproduction,"Co-Head, Department "Development, Reproduction, Cancer," Cochin Institute, INSERM, Cochin Hospital, Paris, France

"Once again the editors of Chesley’s Hypertensive Disorders of Pregnancy have put together an outstanding team of contributors, combining investigators and clinicians, with expertise in preeclampsia to help elucidate our current understanding of this complex disorder. These contributors have put together an exemplary text that highlights recent basic science and clinical research as well as their implications for clinical care and future investigation. I suspect Dr. Chesley would be proud to see that his name continues to lead such an impressive tome."
- Ira M. Bernstein, MD, John van Sicklen Maeck Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Science, College of Medicine, University of Vermont, Burlington, VT, USA

"This 4th edition of Chesley’s classic textbook provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia, its most delicate condition. These range from the epidemiology to the molecular aspects, all analyzed from the background of normal pregnancy. Each chapter has been written by leaders in their respective areas, who discuss pioneering studies to still latent questions, simple interventions to sophisticated future tools, preconceptional management to the risks that mothers and offspring may face in later life. Clinical observations are conciliated with animal models and opposing hypotheses are united into continua (e.g., from an "underfilled" state in early pregnancy to an "overfill" in late pregnancy, from salt as a pressor element to an activator of the immune system). Putting into perspective the advancements made in the 47 years that separate this from the 1st edition illuminates the multiple achievements as well as the bridges that remain to be crossed. This text is a great way to honor the memory of Dr. Leon Chesley, the leader of this still open path, and should be obligatory reading for obstetricians, nephrologists, cardiologists and endocrinologists alike."
- Gloria Valdes, MD, Professor, School of Medicine, Pontifi cia Universidad Católica, Santiago, Chile

Reviews of the Second Edition:

"Preeclampsia remains a lethal enigma of pregnancy. Encompassing more than just hypertension, it can include abnormalities of platelet behavior and clotting mechanisms and of endothelial, hepatic, and renal function. The first edition of Leon Chesley's Hypertensive Disorders in Pregnancy (1978) was a scholarly monograph, written by a scientist with a passionate interest in the condition. Since then, the number of maternal deaths from preeclampsia and eclampsia per million pregnancies has been halved in developed countries. Nevertheless, preeclampsia, together with eclampsia, remains one of the two most frequently cited causes of maternal death in the West. The second edition is a multiauthored book. The three editors are researchers who have made a particular effort to achieve a degree of homogeneity in the presentation. The contents are divided into six main sections, each overseen by one of the three editors. Each chapter is also coauthored by one of the editors, which has resulted in coherence in the writing among chapters. Most of the chapters begin with a paragraph about how the topic was considered by Chesley that emphasizes the forward-looking and comprehensive nature of his interest... This book is an authoritative compilation of knowledge in the area, with many references from the second half of the 1990s. It should certainly be in the library of every academic department."--The New England Journal of Medicine

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