The Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry, 4th Edition

The Practice of Medicinal Chemistry, 4th Edition,Camille Wermuth,David Aldous,Pierre Raboisson,Didier Rognan,ISBN9780124172135
Up to

Wermuth   &   Aldous   &   Raboisson   &   Rognan   

Academic Press



Nicknamed "The Bible" by medicinal chemists shortly after the first edition was published in 1996, this updated text provides a comprehensive overview of the daily issues facing medicinal chemists and pharmaceutical researchers

eBook Overview

EPUB format

PDF format

USD 127.50
USD 150.00
Add to Cart

Key Features

  • Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field
  • Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts
  • Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research
  • An image bank is available for instructors at www.textbooks.elsevier.com


The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough  treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.

With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.


Professors of medicinal chemistry, medicinal chemistry students and pharmaceutical researchers engaged in drug discovery

Camille Wermuth

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Centre d’Etudes Physio-biologiques Appliquées à la Marine" in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine. Professor Wermuths’ main research themes focus on the chemistry and the pharmacology of pyridazine derivatives. The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists. More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF (corticotrophin-releasing factor) which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. Professor Wermuth has also, in collaboration with Professor Jean-Charles Schwartz and Doctor Pierre Sokoloff (INSERM, Paris), developed selective ligands of the newly discovered dopamine D3 receptor. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome. Dr. Wermuth is co-author or editor of several books, the author of over 250 scientific papers and holds nearly 60 patents. Professor Wermuth is also the recipient of the Charles Mentzer Prize of the Société Française de Chimie Thérapeutique, the Léon Velluz Prize of the French Academy of Science, the Prix de l'Ordre des Pharmaciens by the French Academy of Pharmacy and the Nauta Award of the European Federation for Medicinal Chemistry for Pharmacochemistry in 2010.

Affiliations and Expertise

Prestwick Chemical, Illkirch, France

David Aldous

Affiliations and Expertise

Head, LGCR Boston, Sanofi, Boston, MA

Pierre Raboisson

Affiliations and Expertise

Senior Director, Fellow and Head of Infectious Diseases and Vaccines Medicinal Chemistry, Janssen, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium

Didier Rognan

Affiliations and Expertise

Research Director, Laboratoire d'Innovation Thérapeutique, Université de Strasbourg, France

The Practice of Medicinal Chemistry, 4th Edition


Section I: General Aspects of Medicinal Chemistry

1: Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems
2: Evaluation of the biological activity of compounds: Techniques and mechanism of action studies
3: Drug Targets, target identification, validation and screening 

Section II: Lead Compound Discovery Strategies

4: Strategies in the Search for New Lead Compounds or Original Working Hypotheses
5: Natural Products as Pharmaceuticals and Sources for Lead Structures
6: In Silico Screening: Hit Finding from Database Mining
7: Fragment-Based Drug Discovery
8: Molecular Variations Based on Isosteric Replacements
9: Ring Transformations
10: Macro-cycles: Under-explored and Poorly Exploited Drug Class Despite the Proven Therapeutic Potential

Section III: Primary Exploration of Structure-Activity Relationships

11: Conformational restriction and/or steric hindrance in medicinal chemistry
12: Application Strategies for the Primary Structure-Activity Relationship Exploration
13: Substituent groups
14: The Role of Functional Groups in Drug-Receptor Interactions 
15: Compound Properties and their Influence on Drug Quality
16: Pharmacological space
17: Systems Biology: A new paradigm for drug design

Section IV: Substituents and Functions: Qualitative Aspects of Structure-Activity Relationships

18. Optical Isomerism in Drugs
19: Multi-Target Drugs: Strategies and Challenges for Medicinal Chemists
20: Pharmacophore Identification and Pseudo-Receptor Modeling

Section V: Spatial Organization, Receptor Mapping and Molecular Modeling

21: Protein Crystallography and Drug Discovery
22: Physiological Aspects Determining the Pharmacokinetic Properties of Drugs
23: Biotransformation Reactions and their Enzymes
24: Biotransformations Leading to Toxic Metabolites: Chemical Aspects
25: Drug Transport Mechanisms and their Impact on the Disposition and Effects of Drugs
26: Strategies for Enhancing Oral Bioavailability and Brain Penetration
27: Designing Prodrugs and Bioprecursors
28: Drug Delivery with Organic Solvents or Colloidal Dispersed Systems

Section VI: Chemical Modification Influencing the Pharmacokinetic Properties

29: Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
30: Improving the Water-solubility of Compounds by Molecular Modification to Disrupt Crystal Packing
31: Chemical and Physicochemical Approaches to solve Formulation Problems
32: Discover a Drug Substance, Formulate and Develop It to a Product
33: Drug Nomenclature

Section VII: Pharmaceutical and Chemical Means to Solubility and Formulation Problems

34: The use of open access internet resources for medicinal chemistry
35: Legal Aspects of Product Protection - What a Medicinal Chemist should Know About Patent Protection

Quotes and reviews

Praise for the Third Edition of The Practice of Medicinal Chemistry:

"The third edition of this book, useful to seasoned medicinal chemists as well as to chemists entering the academic or industrial laboratories, provides a hands-on overview of the drug discovery process. This edition differs from the previous two editions by having been updated to reflect developments in the past 5 years, and it includes 11 new chapters.

I found this book to be unique, well organized, and overall a useful addition to the medicinal chemistry literature. Having favorably reviewed the first edition, I still highly recommend this third edition to all chemists who are involved in the drug discovery process."
- John L. Neumeyer, Harvard Medical School, in JOURNAL OF MEDICINAL CHEMISTRY from the American Chemical Society

Free Shipping
Shop with Confidence

Free Shipping around the world
▪ Broad range of products
▪ 30 days return policy

Contact Us