NOTE: We are upgrading our eBook operations; please allow up to 1-2 days for delivery of your eBook order.
»
The Practice of Medicinal Chemistry
 
 

The Practice of Medicinal Chemistry, 3rd Edition

 
The Practice of Medicinal Chemistry, 3rd Edition,Camille Wermuth,ISBN9780123741943
 
 
 

C Wermuth   

Academic Press

9780123741943

9780080568775

982

276 X 216

Nicknamed "The Bible" by medicinal chemists shortly after the first edition published in 1996

Print Book + eBook

USD 255.00
USD 425.00

Buy both together and save 40%

Print Book

Hardcover

In Stock

Estimated Delivery Time
USD 220.00

eBook
eBook Overview

DRM Free included formats: PDF

USD 205.00
Add to Cart
 
 

Key Features

NEW TO THIS EDITION:
* Focus on chemoinformatics and drug discovery
* Enhanced pedagogical features
* New chapters including:
- Drug absorption and transport
- Multi-target drugs
* Updates on hot new areas:
NEW! Drug discovery and the latest techniques
NEW! How potential drugs can move through the drug discovery/ development phases more quickly
NEW! Chemoinformatics

Description

Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery/development phases more quickly. This third edition still stands as the only source for practical aspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery.

Readership

Pharmaceutical researchers in drug discovery, chemists

Camille Wermuth

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Centre d’Etudes Physio-biologiques Appliquées à la Marine" in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine. Professor Wermuths’ main research themes focus on the chemistry and the pharmacology of pyridazine derivatives. The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists. More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF (corticotrophin-releasing factor) which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. Professor Wermuth has also, in collaboration with Professor Jean-Charles Schwartz and Doctor Pierre Sokoloff (INSERM, Paris), developed selective ligands of the newly discovered dopamine D3 receptor. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome. Besides about 300 scientific papers and about 60 patents, Professor Wermuth is co-author or editor of several books including; Pharmacologie Moléculaire, Masson & Cie, Paris; Médicaments Organiques de Synthèse, Masson & Cie, Paris; Medicinal Chemistry for the 21st Century, Bl

Affiliations and Expertise

Prestwick Chemical, Illkirch, France

Quotes and reviews

“A useful, authoritative discussion of the principles and practice of medicinal chemistry... the volume has a useful index, is well produced and is very reasonably priced."
- JOURNAL OF MEDICINAL CHEMISTRY
 
 
Discount on Science and Technology eBooks | Use code DRMFREE
NOTE: We are upgrading our eBook operations; please allow up to 1-2 days for delivery of your eBook order.