From Molecules to Networks

From Molecules to Networks, 3rd Edition

An Introduction to Cellular and Molecular Neuroscience

From Molecules to Networks, 3rd Edition,John H. Byrne,Ruth Heidelberger,M. Neal Waxham,ISBN9780123971791

Byrne   &   Heidelberger   &   Waxham   

Academic Press




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Fully revised edition of the cellular and molecular neuroscience textbook intended for graduate and medical students

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Key Features

    * The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches

    * 80% updated and new content

    * New Chapter on "Biophysics of Voltage-Gated Ion Channels"

    * New Chapter on "Synaptic Plasticity"

    * Includes a chapter on the Neurobiology of Disease

    * Highly referenced, comprehensive and quantitative

    * Full color, professional graphics throughout

    * All graphics are available in electronic version for teaching purposes


    An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced.

    All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography).

    Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.


    Graduate and upper undergraduate students Neuroscience, Physiology, Cellular and Molecular Biology, Pharmacology, Psychology, Biochemistry.

    John H. Byrne

    The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and Memory (CSHP).

    Affiliations and Expertise

    University of Texas Medical School, Houston, TX, USA

    View additional works by John H. Byrne

    Ruth Heidelberger

    Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Heidelberger is an accomplished cellular neurophysiologist specializing in mechanisms of neurotransmitter release. She received her doctoral training under the guidance of Gary Matthews and her postdoctoral training under the direction of Nobel Laureate Erwin Neher. Dr. Heidelberger is a former president and executive board member of the Biophysical Society's Subgroup on Exocytosis and Endocytosis and serves on the editorial board of the Journal of Neurophysiology. She has directed and taught graduate-level courses in cellular neurophysiology and membrane biophysics for more than a decade.

    Affiliations and Expertise

    The University of Texas Medical School at Houston, Houston, TX, USA

    M. Neal Waxham

    The William Wheless III Professor, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Waxham’s multi-disciplinary laboratory focuses on the molecular and cellular mechanisms of synaptic function and plasticity. He has developed and directed graduate-level courses in cellular and molecular neurobiology for more than two decades.

    Affiliations and Expertise

    The University of Texas Medical School at Houston, Houston, TX, USA

    From Molecules to Networks, 3rd Edition

    1. Cellular Components of Nervous Tissue
      Patrick R. Hof, Graham Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder and Bruce D. Trapp

    2. Subcellular Organization of the Nervous System: Organelles and Their Functions
      Scott Brady and Peter Brophy

    3. Energy Metabolism in the Brain
      Gerald Dienel

    4. Intracellular Signaling
      Howard Schulman

    5. Regulation of Neuronal Gene Expression and Protein Synthesis
      Cristina Alberini and Eric Klann

    6. Modeling and Analysis of Intracellular Signaling Pathways
      Paul D. Smolen, Douglas A. Baxter and John H. Byrne

    7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters
      Ariel Y. Deutch and Robert H. Roth

    8. Nonclassic Signaling in the Brain
      Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts

    9. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More
      Juan C. Sáez and Bruce Nicholson

    10. Neurotransmitter Receptors
      M. Neal Waxham

    11. Molecular Properties of Ion Channels
      Jason Tien, Yuh Nung Jan and Lily Yeh Jan

    12. Membrane Potential and Action Potential
      David A. McCormick

    13. Biophysics of Voltage-Gated Ion Channels
      Diane Lipscombe

    14. Dynamical Properties of Excitable Membranes
      Douglas A. Baxter and John H. Byrne
    15. Release of Neurotransmitters
      Robert S. Zucker, Dimitri M. Kullmann and Pascal S. Kaeser

    16. Postsynaptic Potentials and Synaptic Integration
      John H. Byrne

    17. Cable Properties and Information Processing in Dendrites
      Michael Beierlein

    18. Synaptic Plasticity
      Ruth Heidelberger, Harel Shouval, Robert S. Zucker and John H. Byrne

    19. Information Processing in Neural Networks
      James J. Knierim

    20. Learning and Memory: Basic Mechanisms
      John H. Byrne, Kevin S. LeBar, Joseph LeDoux, Glenn E. Schafe and Richard F. Thompson

    21. Molecular Mechanisms of Neurological Disease
      Monica Gireud, Natalie Sirisaengtaksin and Andrew J. Bean

    Quotes and reviews

    Jack Byrne is unique in neuroscience. He is at once a first class experimentalist, bringing to bear a variety of cellular, molecular and imaging approaches to study the mechanisms of learning and memory storage. Here his work has led to a number of penetrating insights, including the first demonstration of operant conditioning in Aplysia. But in addition, what makes Byrne’s thinking and work so unique, is that it combines these experimental techniques with realistic and creative mathematical modeling to determine the extent to which the observed processes and interactions are sufficient to explain the behavior of systems he studies.

    This has led to his finding a series of paradigms for enhancing memory storage that are quite remarkable. The Third Edition of From Molecules to Networks is eloquent testimony to this synthesis, the experimental and theoretical and to Jack Byrne’s extraordinary teaching capability, and to his ability to explain science to both students and scientists for which he was recently awarded the National Neuroscience Educational Award.

    - Eric R. Kandel, MD, Department of Neuroscience, Columbia University, New York, NY

    Meshing together the diverse elements of neuroscience, from molecules to man, is one of the great challenges of brain science.  Conveying the integrated story to readers coherently is a major task.  This third edition of the now classic From Molecules to Networks text accomplishes all of this with elegance, even better than the preceding two volumes.  It will be of inestimable value to student and professional alike.

    - Soloman H. Snyder, MD, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD

    Like the previous two editions, this new edition from Byrne, Heidelberger and Waxham is a joy to read: The volume is beautifully produced, the figures make their points perfectly, and the authors of the various chapters are not only experts in their fields, but also have the knack of explaining things clearly. The two best things about this book, though, are that it is completely up-to-date with an emphasis that matches excitement of the field, and that the book’s structure, from molecules to neural circuits, emphasizes organizational principles rather than the more traditional treatment according to a list of neural systems.

    - Charles F. Stevens, MD, PhD, Professor, The Salk Institute, San Diego, CA

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