Eukaryotic Transcription Factors

Eukaryotic Transcription Factors, 5th Edition

Eukaryotic Transcription Factors, 5th Edition,David Latchman,David Latchman,ISBN9780123739834


Academic Press




254 X 178

Provides a clear and concise descriptio of transcription factors and their role in gene regulation.

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Key Features

Brand new coverage in this edition includes:
* Potential of transcription factors as therapeutic targets in human disease
* Importance of histone modifications
* Use of genome-based sequence analysis and high-throughput methods
* Applications of the chromatin immunoprecipitation (ChIP) assay
* Transcriptional elongation
* Regulation by post-translational modifications
* Regulatory networks and bioinformatics


Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.


This book is a mandatory resource for any researcher or student in the life sciences.

Information about this author is currently not available.

David Latchman

Affiliations and Expertise

Master of Birkbeck, University of London, Professor of Genetics, Birkbeck and University College London, UK

View additional works by David S. Latchman

Eukaryotic Transcription Factors, 5th Edition

DNA sequences, transcription factors and chromatin structure; Methods for studying transcription factors; RNA polymerases and the basal transcriptional complex; Families of DNA binding transcription factors; Activation of gene expression by transcription factors; Repression of gene expression by transcription factors; Regulation of transcription factor synthesis; Regulation of transcription factor activity; Transcription factors and human disease
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