Small GTPases in Disease, Part A

Small GTPases in Disease, Part A, 1st Edition

Small GTPases in Disease, Part A, 1st Edition,W. Balch,Channing Der,Alan Hall,ISBN9780123739681

Methods in Enzymology

Balch   &   Der   &   Hall   

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences.

Methods in Enzymology is now available online at ScienceDirect — full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit:

This volume is the first of two planned volumes on the topic of small GTPases and their role in disease.


Researchers in academics and industry studying biochemistry.

W. Balch

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA

View additional works by W. E. Balch

Channing Der

Affiliations and Expertise

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA

View additional works by Channing J. Der

Alan Hall

Affiliations and Expertise

University College of London, U.K.

View additional works by Alan Hall

Small GTPases in Disease, Part A, 1st Edition

Chapter 1
Rab1b silencing using small interfering RNA for analysis of disease specific function
Darren M. Hutt, William E. Balch

Chapter 2
Rab8-optineurin-myosin VI: Analysis of interactions and functions in the secretory pathway
Margarita V. Chibalina, Rhys C. Roberts, Susan D. Arden, John Kendrick-Jones and Folma Buss

Chapter 3
Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate specific antigen in prostate carcinoma cells
Sergio D. Catz

Chapter 4
In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors
Jean-Christophe Zeeh, Bruno Antonny, Jacqueline Cherfils, Mahel Zeghouf

Chapter 5
Analysis of small GTPase function in trypanosomes
Mark C. Field, David Horn and Mark Carrington

Chapter 6
Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis
Tom Kirchhausen, Eric Macia, Henry E. Pelish

Chapter 7
Identification and verification of Sro7p as an effector of the Sec4p rab GTPase
Bianka Grosshans1 and Peter Novick

Chapter 8
Characterization of Rab18, a Lipid Droplet Associated Small GTPase
Sally Martin, Robert G. Parton

Chapter 9
Analysis on the Emerging Role of of Rab3 GTPase-activating Protein in Warburg Micro and Martsolf Syndrome
Ayuko Sakane, Jun Miyoshi, Yoshimi Takai, Takuya Sasaki

Chapter 10
Identification and Characterization of JRAB/MICAL-L2, a Junctional Rab13-binding Protein
Noriyuki Nishimura and Takuya Sasaki

Chapter 11
A SMAP Gene Family Encoding ARF GTPase-activating Proteins and Its Implication in Membrane Trafficking

Chapter 12
In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1.
Pedro F. Esteban, Paola Caprari, Hye-Young Yoon, Paul A. Randazzo & Lino Tessarollo

Chapter 13
Methods for analysis of rab27a/munc13-4 in secretory lysosome release in haematopoietic cells
Peter van der Sluijs, Maaike Neeft, Thijs van Vlijmen, Edo Elstak, and Marnix Wieffer

Chapter 14
Analysis and expression of Rab38 in Oculocutaneous Lung Disease
Kazuhiro Osanai, Dennis R. Voelker

Chapter 15
Analysis of Rab1 function in cardiomyocyte growth
Guangyu Wu, Catalin M. Filipeanu, Fuguo Zhou

Chapter 16
Regulation of the Trafficking and Function of G Protein-coupled Receptors by Rab1 GTPase in Cardiomyoctyes
Guangyu Wu

Chapter 17
Regulation of endosome dynamics by Rab5 and its Huntingtin-HAP40 effector complex in physiological versus pathological conditions
Arun Pal, Fedor Severin, Sebastian Höpfner and Marino Zeria

Chapter 18
Sonia Terrillon and Dafna Bar-Sagi

Chapter 19
Biochemical Characterization of Novel Germline BRAF and MEK Mutations in Cardio-facio-cutaneous Syndrome
Pablo Rodriguez-Viciana and Katherine A. Rauen

Chapter 20
Biochemical and biological characterization of tumor-associated mutations of p110a
Adam Denley, Marco Gymnopolous, Jonatha R. Hart, Hao Jiang, Li Zhao, Peter K. Vogt

Chapter 21
Characterization of the Rheb-mTOR signaling pathway in mammalian cells:
Constitutive active mutants of Rheb and mTOR
Tatsuhiro Sato, Akiko Umetsu, Fuyuhiko Tamanoi

Chapter 22
Characterization of RalB-Sec5-TBK1 Function in Human Oncogenesis
Yuchen Chien and Michael A. White

Chapter 23
High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor
Ultan McDermott, Sreenath V. Sharma, Jeffrey Settleman

Chapter 24
In vitro signalling by MAPK and NFkB pathyways inhibited by Yersinia YopJ
Sohini Mukherjee, Kim Orth

Chapter 25
Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways.
Jennifer L. Bromberg-White and Nicholas S. Duesbery

Chapter 26
Genetic analyses of the role of RCE1 in RAS membrane association and transformation
Martin O. Bergo, Annika M. Wahlstrom, Loren G. Fong, Stephen G. Young

Chapter 27
Characterization of Kras Mediated Pancreatic Tumorigenesis in Zebrafish
Jon M. Davison, Seung Woo Park, Jerry M. Rhee, Steven D. Leach

Chapter 28
Genetic Modeling of Ras-Induced Human Rhabdomyosarcoma
Corinne M. Linardic, Christopher M. Counter
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