Principles of Bone Biology

3rd Edition - September 29, 2008
Editors: John P. Bilezikian, Lawrence G. Raisz, T. John Martin
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 3 7 3 8 8 4 - 4
eBook ISBN:
9 7 8 - 0 - 0 8 - 0 5 6 8 7 5 - 1

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone… Read more

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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders.

Part I Basic Principles
A. Cell Biology

1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity
Ego Seeman

2: Biomechanics of Bone
Elise Morgan

3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation
Andrew Karaplis

4: Mesenchymal Stem Cells & Osteoblast Lineage
Jane Aubin

5: Transcriptional Control of Osteoblast Differentiation and Function
Thorsten Schinke

6: Wnt Signaling and Bone
Mark Johnson

7: Sclerostin and Bone
Rutger van Bezooijen

8: The Osteocyte
Jenneke Klein-Nulend

9: Cells of Bone: Osteoplast Generation
Tatsuo Suda

10: Osteoclast Function: Biology and Mechanisms
Kalervo Vaananen

11: RANK Signaling
Hiroshi Takanayagi

12: Regulating Bone Resorption
Roland Baron

13: Apoptosis in Bone Cells
Stavros Manolagas

14: Skeletal Gene Expression in Nuclear Microenvironments
Gary Stein

B. Biochemistry

15: Type I Collagen: Structure, Synthesis, and Regulation
Benoit de Crombrugghe

16: Collagen Crosslinking & Metabolism
Simon Robins

17: Bone Matrix Proteoglycans & Glycoproteins
Pamela Robey

18: Osteopontin
Masaki Noda

19: Bone Proteinases
Nicola Partridge

20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells
Michael Horton

21: Intercellular Junctions and Cell-Cell Communication in the Skeletal System
Roberto Civitelli

C. Bone Remodeling and Mineral Homeostasis

22: Histomorphometric Analysis of Bone Remodeling
David Dempster

23: Phosphorus Homeostasis & Related Disorders
Marc Drezner

24: Magnesium Homeostasis
Robert Rude

25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro
Felix Bronner

26: Biology of the Extracellular Ca2+-Sensing Receptor
Edward Brown

D. The Hormones of Bone

27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein
John Potts

28: Parathyroid Hormone - Molecular Biology
Hank Kronenberg

29: Parathyroid Hormone-Receptor Interactions
Mike Rosenblatt

30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System
John Bilezikian

31: The Vascular and Cardiovascular Actions of PTH
John Bilezikian

32: PTH and PTHrP Actions on Kidney and Bone
Peter Friedman

33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein
John Wysolmerski

34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein
Thomas Clemens

35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses
Tony Norman

36: Vitamin D Gene Regulation
Sylvia Christakos

37: Photobiology and Non-Calcemic Actions of Vitamin D
Mike Holick

38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects
Bob Gagel

39: Amylin and Calcitonin Gene-Related Peptide
Jill Cornish

E. Other Systemic Hormones That Influence Bone Metabolism

40: Estrogens & Progestins
Russell Turner

41: The Pharmacology of Selective Estrogen Receptor Modulators
Henry Bryant

42: Mechanisms of Estrogen Action in Bone
Roberto Pacifici

43: Thyroid Hormone & Bone
Paula Stern

44: Clinical and Basic Aspects of Glucocorticoid Action in Bone
Barbara Kream

45: Effects of Diabetetes & Insulin on Bone Physiology
Johan Verhaeghe

46: Androgens:Receptor Expression and Steroid Action in Bone
Kristine Wiren

47: Kinins & Neuro-Osteogenic Factors
Ulf Lerner

48: Regulation of Bone Remodeling by Central and Peripheral Nervous Signals
Patricia Ducy

F. Local Regulators

49: Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology
Cliff Rosen

50: Platelet-Derived Growth Factor & the Skeleton
Ernesto Canalis

51: Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone
Marja Hurley

52: Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling
Dwight Towler

53: Transforming Growth Factor-â
Sarah Dallas

54: Bone Morphogenetic Proteins and the Skeleton
Vicki Rosen

55: Bone Morphogenetic Protein Receptors & Actions
Kohei Miyazono

56: Colony-Stimulating Factor-1
Willy Hofstetter

57: Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional Cytokines
Mark Horowitz

58: Prostaglandins & Bone Metabolism
Carol Pilbeam

Part II Molecular Mechanisms of Metabolic Bone Disease

59: Skeletal Effects of Nitric Oxide: Novel Agent for Osteoporosis
Sunil Wimalawansa

60: Molecular Basis of PTH Overexpression
Andy Arnold

61: Familial Benign Hypocalciuric Hypercalcemia and Neonatal Primary Hyperparathyroidism
Ghada EI-Hajj Fuleihan

62: Multiple Endocrine Neoplasia Type I
Maria Luisa Brandi

63: Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy
David Goltzman

64: Local Factors in Skeletal Malignancy
Greg Mundy

65: Genetic Regulation of the Parathyroid Gland Development
Raj Thakker

66: Jansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor Mutations
Harald Jueppner

67: Diseases Resulting from Defects in the G Protein Gs
Lee Weinstein

68: Renal Osteodystrophy – Pathogenic Mechanisms and Therapeutic Options
Bill Goodman

69: Osteogenesis Imperfecta
David Rowe

70: Hereditary Deficiencies in Vitamin D Action
Uri Liberman

71: Oncogenic Osteomalacia
Suzanne Jan de Beur

72: Osteopetrosis
Lyndon Key

73: Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans
Michael Whyte

74: Paget's Disease of Bone
Fred Singer

75: Genetic Determinants of Bone Mass and Osteoporotic Fracture
Stuart Ralston

76: Pathophysiology of Osteoporosis
Bilezikian, Raisz, Martin

77: Evaluation of Risk for Osteoporosis Fracture
Stuart Silverman

Part III Pharmacological Mechanisms of Therapeutics

78: Parathyroid Hormone
Dave Hanley

79: Calcium
Robert Heaney

80: Drugs Acting on the Calcium Receptor Calcimimetics and Calcilytics
Edward Nemeth

81: Bisphosphonates: Mechanisms of Action
Graham Russell

82: The Pharmacology of Estrogens in Osteoporosis
Robert Lindsay

83: Vitamin D & Analogs
Glenville Jones

84: Estrogen Effects on Bone in the Male Skeleton
Luigi Gennari

85: Mechanisms of Exercise Effects on Bone Quantity and Quality
Clint Rubin

Part IV Methods in Bone Research

86: Application of Transgenic Mice to Problems of Skeletal Bone
Stephen Clark

87: Biochemical Markers of Bone Metabolism
Markus Seibel

88: Methods and Clinical Issues in Bone Densitometry
Glen Blake

89: Controversial Issues in Bone Densitometry
Paul Miller

90: Macro and Micro Imaging of Bone Architecture
Klaus Engelke, Sven Prevrhal, and Harry K. Genant

John P. Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and expertise

Columbia University, New York, New York, U.S.A.

Lawrence G. Raisz

Dr. Raisz is Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center. He has been carrying out laboratory and clinical studies in the field of osteoporosis and bone metabolism for over 40 years. He has mentored a large number of investigators in these areas both here at the University of Connecticut and previously at the University of Rochester School of Medicine. His current studies include an analysis of the effects of estrogen and androgen on the expression of cytokines and growth factors in bone, which is being carried out in both humans and animal models, studies of the role of prostaglandins in bone metabolism using transgenic mice, studies on the effects of progestins on bone turnover in postmenopausal women and tissue culture and animal studies on new antiresorptive and anabolic agents carried out in collaboration with the pharmaceutical industry.

Affiliations and expertise

Professor of Medicine and Program Director of the General Clinical Research Center at the University of Connecticut Health Center

T. John Martin

Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.

Affiliations and expertise

St. Vincent’s Institute of Medical Research, Melbourne, Australia