The Mitochondrion in the Germline and Early Development

The Mitochondrion in the Germline and Early Development, 1st Edition

The Mitochondrion in the Germline and Early Development, 1st Edition,Justin St. John,Gerald Schatten,ISBN9780123736628

Current Topics in Developmental Biology

St. John   &   Schatten   

Academic Press




229 X 152

Exciting essays in the mitochondrion in the germline and early development

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Key Features

* Includes many descriptive figures
* Topics covered include the role of mitochondrial function, the use of ARTs to regulate mtDNA disease, nuclear transfer, and more
* Latest volume in the series that covers 10 reviews from leading authorities in developmental biology


Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.


Developmental biologists, cell biologists, genetics researchers, molecular biologists, and plant and animal biologists

Justin St. John

Affiliations and Expertise

The Medical School, The University of Birmingham, U.K.

Gerald Schatten

Affiliations and Expertise

University of Pittsburgh School of Medicine, PA, U.S.A.

View additional works by Gerald P. Schatten

The Mitochondrion in the Germline and Early Development, 1st Edition

Section I. The mitochondrion and gametes

Chapter 1
The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?
Eduardo Ruiz-Pesini, Carmen Díez-Sánchez, Manuel José López-Pérez and José Antonio Enríquez

Chapter 2
The role of mitochondrial function in the oocyte and embryo
Remi Dumollard, Michael Duchen, John Carroll

Chapter 3
Mitochondrial DNA in the Oocyte and the developing embryo
Pascale May-Panloup, Marie-Françoise Chretien, Yves Malthier, Pascal Reynier

Section II. Transmission

Chapter 4
Mitochondrial DNA and the mammalian oocyte
Eric A. Shoubridge and Timothy Wai

Chapter 5
Mitochondrial disease - its impact, aetiology and pathology
McFarland R, Taylor RW and Turnbull DM

Chapter 6
Cybrid models of mtDNA disease and transmission, from cells to mice
Ian A. Trounce, Carl A. Pinkert

Section III. The use of ARTs to regulate mtDNA disease.

Chapter 7
The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA
Helena Fulka, Josef Fulka, Jr.

Chapter 8
Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo
Joanna Poulton, Pippa Oakeshott, Stephen H. Kennedy

Section IV. The effects of invasive ARTs on mtDNA transmission

Chapter 9
Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion
Carol Brenner, A. J. Harvey, T. C. Gibson

Chapter 10
Nuclear Transfer - preservation of a nuclear genome at the expense of its associated mtDNA genome(s)
Emma J. Bowles, Keith H. S. Campbell, Justin C. St. John

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