Clinical and Translational Science

Clinical and Translational Science, 1st Edition

Principles of Human Research

Clinical and Translational Science, 1st Edition,David Robertson,Gordon Williams,ISBN9780123736390

Robertson   &   Williams   

Academic Press




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Key Features

* Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications

* Contributions from international leaders provide insight into background and future understanding for clinical and translational science

* Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research


Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health.

This book is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science.


Investigators and clinicians involved in endocrinology, immunology, virology, microbiology, cell biology, pharmacology, and genetics research; post-doctoral fellows and graduate researchers; instructors and trainees in national and international technical clinician and degree programs

David Robertson

Affiliations and Expertise

Departments of Medicine, Pharmacology, and Neurology, Clinical Research Center, Vanderbilt University, Nashville, TN, USA

View additional works by David Robertson

Gordon Williams


Affiliations and Expertise

Chief, Endocrine Hypertension Division, Brigham and Women's Hospital, Boston, MA

Clinical and Translational Science, 1st Edition

List of Contributors Foreword Acknowledgments Introduction to Clinical Research Part I Fundamental Principles 1 Patient-Oriented Research: Clinical Pathophysiology and Clinical Therapeutics 2 Clinical Trials Part II Approaches 3 Experimental Design 4 Introduction to Biostatistics Ideas 5 Measurement of Biological Materials 6 Imaging Tools in Human Research 7 Imaging Tools in Cardiovascular Research 8 Nanotechnology in Clinical and Translational Research 9 The Use of Questionnaires and Surveys 10 Information Technology Part III Infrastructure 11 Clinical and Translational Science Infrastructure 12 Industry-Sponsored Clinical Research in Academia Part IV Education, Training and Career Choices 13 Training Basic, Clinical and Translational Investigators 14 A Stepwise Approach to a Career in Translational Research 15 Physician Careers in Industry Part V Funding 16 Governmental Support of Research 17 Support of Health Research by Private Philanthropy 18 Pharmaceutical and Biotechnology Sector Support of Research Part VI Human Genetics 19 Introduction to Human Genetics 20 Epidemiologic and Population Genetic Studies 21 Pharmacogenetics of Drug Metabolism Part VII Human Pharmacology 22 Introduction to Clinical Pharmacology 23 Toxicology and Genetics of Adverse Drug Events 24 Good Clinical Practice and Good Laboratory Practice 25 Modern Drug Discovery and Development Part VIII Societal Context of Human Research 26 Translating Science to the Bedside: The Innovation Pipeline 27 Regulatory Environment 28 Ethical Issues in Translational Research and Clinical Investigation 29 Clinical Research in the Public Eye Part IX Research in Special Populations 30 Acute Illnesses, Critical Care, Emergency and Surgical Patients 31 Psychiatric Disorders 32 Geriatrics 33 Pediatrics Part X Population-Based Research 34 Pharmacoeconomics: The Economic Evaluation of New Medical Technology 35 Introduction to Epidemiology 36 Health Services Research: Translating Discovery and Research into Practice and Policy Part XI Prospectus 37 The Future of Clinical Research Index
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