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Principles of Behavioral Genetics
 
 

Principles of Behavioral Genetics, 1st Edition

 
Principles of Behavioral Genetics, 1st Edition,Robert RH Anholt,Trudy Mackay,ISBN9780123725752
 
 
 

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Academic Press

9780123725752

9780080919898

344

Textbook covering the relationship between genes, brain and behavior.

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Key Features

* Defines the emerging science of behavioral genetics
* Engagingly written by two leading experts in behavioral genetics
* Clear explanations of basic quantitative genetic, neurogenetic and genomic applications to the study of behavior
* Numerous examples ranging from model organisms to non-model systems and humans
* Concise overviews and summaries for each chapter

Description

Principles of Behavioral Genetics presents the field of behavioral genetics. It emphasizes unifying principles, which, as a comprehensive discipline, encompasses not only studies of model organisms but the study of people, as well. Along with addressing behavior as a consequence of genetics, the book demonstrates the neurobiological and ecological aspects of behavioral genetics. In addition, it discusses evolutionary genetics and gene flow populations in relation to behavioral genetics. The book starts by discussing the history of the young field of behavioral genetics, and it continues with a description of the fundamental functions and the organization of the nervous system. The book goes on to offer basic topics related to quantitative genetic principles, and it focuses on a wide range of commonly studied behaviors, including chemoreception, circadian activity and sleep, social behaviors, locomotion, learning and memory, and addiction. This book will be a valuable resource for future generations of scientists who focus on the field of behavioral genetics.

Readership

Advanced undergraduate and graduate students in genetics, neuroscience, or ecology courses on behavior.

Robert RH Anholt

Affiliations and Expertise

W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC, U.S.A.

Trudy Mackay

Principles of Behavioral Genetics, 1st Edition

Preface Chapter 1: Introduction and Historical Perspective Overview The Rise of the Modern Field of Behavioral Genetics The Modern Evolutionary Synthesis The Rise of Molecular Genetics A Brief History of Neuroscience The Emergence of Behavioral Genetics Summary Study Questions Recommended Reading Chapter 2: Mechanisms of Neural Communication Overview Transmission of Information in the Nervous System The Resting Membrane Potential The Mechanism of the Action Potential Ion Channels, G-protein-coupled Receptors, and Signal Transduction Summary Study Questions Recommended Reading Chapter 3: Functional Organization of the Nervous System Overview The Organization of the Mammalian Nervous System Communication between the Brain and the Periphery Organization of the Nervous System in Insects Neurotransmitters Summary Study Questions Recommended Reading Chapter 4: Measuring Behavior: Sources of Genetic and Environmental Variation Overview Behavioral Assays Controlling Experimental Variation Sources of Variation in Behavior Effects of Mutations on Behavioral Phenotypes Environmental Variation Gene - Environment Correlation and Interaction Summary Study Questions Recommended Reading Chapter 5: Mapping Genotype to Phenotype in Populations Overview Genes in Populations: Random Mating Genes in Populations: Inbreeding Quantitative Genetic Model Summary Study Questions Recommended Reading Chapter 6: Partitioning Phenotypic Variance and Heritability Overview Components of Variance in Random Mating Populations Genotype-Environment Correlation and Interaction Partitioning Phenotypic Variance Heritability : The Concept Controlling and Estimating Environmental Components of Variation Summary Study Questions Recommended Reading Chapter 7: Estimating Heritability Overview Phenotypic Resemblance between Relatives Genetic Causes of Covariance between Relatives Environmental Causes of the Relationship between Relatives Heritability Estimates in Humans Heritability in Other Populations Estimates of Heritability for Behavioral Traits Summary Study Questions Recommended Reading Chapter 8: Quantitative Trait Locus Mapping Overview Linkage Mapping Interval Mapping Statistical Analysis Association Mapping Quantitative Trait Locus End Game Summary Study Questions Recommended Reading Chapter 9: Mutagenesis and Transgenesis Overview The Occurrence or Induction of Mutations Homologous Recombination Transposon -mediated Mutagenesis The GAL4-UAS Binary Expression System in Drosophila RNA Interference Summary Study Questions Recommended Reading Chapter 10: Genomics Approaches in Behavioral Genetics Overview Detecting Large-scale Gene Expression Parallel Sequencing and Transcriptional Analysis Plasticity of Transcriptional Profiles Analysis of Whole-genome Expression Microarray Defining Statistical Signifi cance Threshold Identifying Genetic Networks Summary Study Questions Recommended Reading Chapter 11: Neurogenetics of Activity and Sleep Overview Locomotion Genetics of Human Locomotion Disorders Circadian Rhythms Sleep Summary Study Questions Recommended Reading Chapter 12: Genetics of Social Interactions Overview Social Environment and the Genes-Brain-Behavior Paradigm Social Cooperation and Fitness Courtship and Mate Selection Affiliative Behavior Aggression and the Establishment of Social Hierarchies Division of Labor: The Genetics of Social Structure Aggregation Behavior Summary Study Questions Recommended Reading Chapter 13: Genetics of Olfaction and Taste Overview The Study of Olfaction The Discovery of Odorant Receptors Transgenic Approaches to Determine Odorant Receptor Response Profiles Transgenic Approaches to Map Projection Patterns of Olfactory Sensory Neurons The Use of Transgenic Reporter Genes to Visualize Odor Coding Taste and Gustatory Receptors Summary Study Questions Recommended Reading Chapter 14: Learning and Memory Overview Forming Memories Memory Formation: Cellular Mechanisms Harnessing the Power of Genetics: Learning in Drosophila Identifying Genetic Networks for Learning and Memory Learning Disabilities Neurodegeneration and Memory Impairment: Alzheimer’s Disease Summary Study Questions Recommended Reading Chapter 15: Genetics of Addiction Overview Hallmarks of Addiction Alcoholism Linkage and Association Studies Alcohol Sensitivity in Model Organisms Alcohol-related Phenotypes in Rodent Models Smoking Drug Addiction Summary Study Questions Recommended Reading Chapter 16: Evolution of Behavior Overview Population Genetics and Evolution Models of Evolution Selection Models Assessing Deviations from Neutrality Behavior as a Vehicle for Evolution Insect-Host Plant Interactions: An Example of Evolutionary Adaptation Co-evolution of Sexual Communication Systems Study Questions Recommended Reading Chapter 16: Evolution of Behavior Overview Population Genetics and Evolution Models of Evolution Selection Models Assessing Deviations from Neutrality Behavior as a Vehicle for Evolution Insect-Host Plant Interactions: An Example of Evolutionary Adaptation Co-evolution of Sexual Communication Systems The Evolutionary Genetics of Burrowing and Nest Building The Astounding Diversity of Cichlids and Sticklebacks Understanding the Evolution of Behavior: How Much Do We Really Know? Summary Study Questions Recommended Reading Glossary Index
 
 

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