The Bioarchaeology of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease, 1st Edition

The Bioarchaeology of Metabolic Bone Disease, 1st Edition,Megan Brickley,Rachel Ives,ISBN9780123704863


Academic Press




229 X 152

This is the first book that concentrates exclusively on metabolic bone diseases in archaeological human bone.

Print Book + eBook

USD 115.74
USD 192.90

Buy both together and save 40%

Print Book


In Stock

Estimated Delivery Time
USD 98.95

eBook Overview

VST format:

DRM Free included formats: EPub, Mobi, PDF

USD 93.95
Add to Cart

Key Features

*Clear photographs and line drawings illustrate gross, histological and radiological features associated with each of the conditions
*Covers a range of issues pertinent to the study of metabolic bone disease in archaeological skeletal material, including the problems that frequent co-existence of these conditions in individuals living in the past raises, the preservation of human bone and the impact this has on the ability to suggest a diagnosis of a condition
*Includes a range of conditions that can lead to osteopenia and osteoporosis, including previous investigations of these conditions in archaeological bone


The Bioarchaeology of Metabolic Bone Disease provides a comprehensive and invaluable source of information on this important group of diseases. It is an essential guide for those engaged in either basic recording or in-depth research on human remains from archaeological sites. The range of potential tools for investigating metabolic diseases of bone are far greater than for many other conditions, and building on clinical investigations, this book will consider gross, surface features visible using microscopic examination, histological and radiological features of bone, that can be used to help investigate metabolic bone diseases.


A wide range of individuals engaged in the study of physical anthropology, paleopathology, medical history and forensic anthropology.

Megan Brickley

Affiliations and Expertise

University of Birmingham, The Institute of Archaeology and Antiquity, UK

Rachel Ives

Affiliations and Expertise

University of Birmingham, The Institute of Archaeology and Antiquity, UK

The Bioarchaeology of Metabolic Bone Disease, 1st Edition

Acknowledgments Foreword Chapter 1. Introduction Metabolic Bone Disease: A Definition Format of the Book Chapter 2. The Study of Metabolic Bone Disease in Bioarchaeology Approaches to the Study of Metabolic Bone Disease Challenges in the Investigation of Metabolic Bone Disease Museum Collections Archaeological Human Bone Paleopathological Diagnoses Demographic Issues Modern Medical Data Genetics and Anthropology Cultural and Social Anthropology Nutritional and Medical Anthropology Primatology Conclusions Chapter 3. Background to Bone Biology and Mineral Metabolism Bone Tissue: Cortical and Trabecular Bone Different Types of Bone Structure: Woven Bone and Lamellar Bone Bone Cells Modeling and Remodeling: Growth and Adulthood Mechanisms of Growth Modeling Remodeling Bone Mineralization: The Extracellular Matrix (osteoid) Tooth Formation and Mineralization Reasons for Remodeling Box Feature 3.1. Bone Biology in Context of the Life Course Bone Biology in Fracture Healing Mineral Metabolism during Life Extracellular Mineral Metabolism Conclusions Chapter 4. Vitamin C Deficiency Scurvy Causes of Vitamin C Deficiency Sources of Vitamin C Box Feature 4.1. Scurvy and Weaning The Role of Vitamin C Vitamin C Requirements Consequences of Scurvy Consequences for Adults Consequences for Children Scurvy in the Modern Perspective Anthropological Perspectives Reference to Probable Scurvy in Early Texts Box Feature 4.2. Subsistence Change and the Development of Scurvy: The Origins of Agriculture A More Recent View of Scurvy in the Past Paleopathological Cases of Scurvy Diagnosis of Scurvy in Archaeological Bone Macroscopic Features of Infantile Scurvy Macroscopic Features of Adult Scurvy Radiological Features of Infantile Scurvy Radiological Features of Adult Scurvy Histological Features of Infantile Scurvy Histological Features of Adult Scurvy Differential Diagnosis Box Feature 4.3. Scurvy in Non-Human Primates: A Result of Human Actions Conclusions Appendix: Summary of Published Archaeological Evidence for Vitamin C Deficiency Chapter 5. Vitamin D Deficiency The Skeletal Requirement of Vitamin D Terminology Causes of Vitamin D Deficiency Sunlight Cultural Practices and Sunlight Exposure Skin Pigmentation and Genetic Adaptations Food Sources Pregnancy and Lactation Increased Age Age-Related Osteoporosis Additional Causes of Vitamin D Deficiency with Effects on Mineral Metabolism Rickets Consequences of Rickets Historical Recognition of Rickets Rickets in the Modern Perspective Anthropological Perspectives: Rickets Box Feature 5.1. Beyond Fighting: The Physiological Impact of Warfare Paleopathological Cases of Rickets Diagnosis of Rickets in Archaeological Bone Macroscopic Features of Rickets Radiological Features of Rickets Histological Features of Rickets Residual Rickets in the Anthropological Perspective: Adult Evidence of Childhood Vitamin D Deficiency Diagnosis of Residual Rickets in Archaeological Bone Macroscopic Features of Residual Rickets Radiological Features of Residual Rickets Histological Features of Rickets Co-Morbidities Differential Diagnosis Vitamin D Deficiency Osteomalacia Pseudofractures Adult Vitamin D Deficiency in the Modern Perspective Box Feature 5.2. Physical and Non-Violent Manifestations of Abuse Anthropological Perspectives: Osteomalacia Paleopathological Cases of Osteomalacia Diagnosis of Osteomalacia in Archaeological Bone Macroscopic Features of Osteomalacia Radiological Features of Osteomalacia Histological Features of Osteomalacia Conclusions Appendix: Summary of Published Archaeological Evidence for Vitamin D Deficiency Chapter 6. Age-Related Bone Loss and Osteoporosis Definitions of Osteoporosis Causes of Age-Related Osteoporosis Menopause Increased Age Peak Bone Mass Mechanical Loading Extremes of Exercise Continuing Sub-Periosteal Apposition Genetics and Population Groups Nutrition and Lifestyle Skeletal Features of Age-Related Osteoporosis Consequences of Age-Related Osteoporosis: Fractures Distal Radius Fractures (Colles ’ Fractures) Vertebral Fractures Femoral Fractures Osteoporosis in the Modern Perspective Anthropological Perspectives Box Feature 6.1. Historical and Anthropological Perspectives of Aging Age-Related Osteoporosis in Men Box Feature 6.2. Animal Studies in Osteoporosis I: Age-Related Bone Loss Box Feature 6.3. Problems in the Determination of Age-Related Bone Changes in Biological Anthropology Paleopathological Cases of Age-Related Osteoporosis Co-Morbidities Diagnosis of Age-Related Bone Loss and Osteoporosis in Archaeological Bone Macroscopic Features of Osteoporosis Radiological Features of Osteoporosis Histological Changes of Osteoporosis Conclusions Chapter 7. Secondary Osteopenia and Osteoporosis Causes of Secondary Osteopenia and Osteoporosis Osteopenia and Mobility Effects of Immobilization Box Feature 7.1. Animal Studies in Osteoporosis II: Immobilization-Related Osteopenia Trauma and Causes of Immobility Non-Long Bone Trauma and Additional Causes of Disuse Osteoporosis Bone Loss in Infectious Diseases Immobility in Viral Conditions Congenital and Developmental Conditions Osteopenia in Spinal Cord or Neuromuscular System Afflictions Box Feature 7.2. Implications of Immobility and Inferences of Disability Osteopenia in Pathological Conditions Joint Disease Hematopoietic Conditions Neoplastic and Malignant Conditions The Influence of Diet on Osteoporosis Risk Dietary Acid Load and Proposed Mechanisms of Bone Loss Calcium Protein Fatty Acids Fruit and Vegetables Anthropological Perspectives Calcium in the Evolutionary Perspective The Effect of Meat Eating on Calcium Adequacy Box Feature 7.3. The Health of Adaptive and Transitional Diets: Integrated Approaches? Calcium Availability with the Onset of Domestication Diagnosis of Secondary Osteopenia in Archaeological Bone Conclusions Chapter 8. Paget’s Disease of Bone POSSIBLE CAUSES OF PAGET’S DISEASE Box Feature 8.1. Animal Paleopathology Consequences of Paget’s Disease Pelvic Changes Cranial Changes Long Bone Changes Other Bones that can be Affected Co-Morbidities Paget’s Disease in the Modern Perspective Age and Sex Geographic Variation Anthropological Perspectives Paleopathological Cases of Paget’s Disease Diagnosis of Paget’s Disease in Archaeological Bone Macroscopic Features of Paget’s Disease Radiological Features of Paget’s Disease Histological Features of Paget’s Disease Differential Diagnosis Box Feature 8.2. The Contribution of Paleopathology to Modern Medicine Conclusions Chapter 9. Miscellaneous Conditions Fluorosis Consequences of Fluorosis Dental Fluorosis Skeletal Fluorosis Co-Morbidities Fluorosis in the Modern Perspective Anthropological Perspectives: Fluorosis Paleopathological Cases of Fluorosis Other Conditions Linked to Intoxication Hyperparathyroidism Causes of Hyperparathyroidism Primary Hyperparathyroidism Secondary Hyperparathyroidism Consequences of Hyperparathyroidism Anthropological Perspectives: Hyperparathyroidism Paleopathological Cases of Hyperparathyroidism Diagnosis of Hyperparathyroidism in Archaeological Bone Pellagra Box Feature 9.1. Anthropological Investigations of Displaced Peoples Starvation Box Feature 9.2. Malnutrition, Starvation and Osteoporosis Rare Metabolic Bone Diseases Hyperostosis Hypophosphatasia Osteogenesis Imperfecta Osteopetrosis Conclusions Chapter 10. Overview and Directions for Future Research Bone Biology Vitamin C Deficiency, Scurvy Vitamin D Deficiency, Rickets and Osteomalacia Age-Related Osteoporosis Secondary Osteopenia and Osteoporosis Paget’S Disease of Bone Miscellaneous Metabolic Bone Diseases Conclusions Bibliography Index

Quotes and reviews

"[Bioarchaeology of Metabolic Bone Disease] takes us along a fascinating exploratory journey of the main (and not so common) metabolic bone diseases identifiable in skeletal remains. Useful supporting tables, and clear photographic images and line drawings, supplement the text, with a concluding chapter providing a view of future research...."

Professor Charlotte A. Roberts
Department of Archaeology
Durham University

"The authors’ cogent discussion of how elements within a given lifestyle, including diet/nutrition, cultural practices, socio-economic status, and the surrounding environment, can significantly impact the health of individuals and of societies is illustrated with abundant well-chosen anthropological examples. This volume will be of great value to all scholars devoted to accurate, informative reconstructions of past human life."

Mary Lucas Powell, Ph.D.
Past Editor, Paleopathology Newsletter
The Paleopathology Association
Cyber Monday SALE Upto 50 Percent OFF | Use Code CYBER14
Shop with Confidence

Free Shipping around the world
▪ Broad range of products
▪ 30 days return policy

Contact Us