Natural Killer Cells, 1st Edition

Basic Science and Clinical Application

Natural Killer Cells, 1st Edition,Michael Lotze,Angus Thomson,ISBN9780123704542

Lotze   &   Thomson   

Academic Press




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Key Features

- Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners
- Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
- Companion website includes full-color image database


Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine.


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Michael Lotze

Affiliations and Expertise

Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

View additional works by Michael T. Lotze

Angus Thomson

Affiliations and Expertise

Departments of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

View additional works by Angus W. Thomson

Natural Killer Cells, 1st Edition

Contributors Foreword Preface Part I. NK biology 1 Developmental stages and pathways of NK cell maturation 2 Developmental origins of thymus-derived natural killer cells 3 Interferon-producing killer dendritic cells (IKDC) 4 Natural killer cells in cancer 5 NK cell immune recognition: NKG2D ligands and stressed cells 6 NK cell KIR heterogeneity and evolution 7 Signalling events in natural killer cells 8 Human natural killer cell development Part II. NK interactions with other cells 9 Isolation, culture and propagation of natural killer cells 10 The localization and migration of natural killer cells in health and disease 11 Receptors on NK cells 12 Development and testing of NK cell lines 13 NK cell-derived cytokines and delivery: NK cell synapses 14 NK cells as recipients of cytokine signals 15 NK cells and chemokines 16 Natural killer cytolytic activity 17 Illuminating intranodal natural killer cell behaviour using two-photon microscopy 18 Dendritic cells and NK cells 19 NK and NKT cells: the innate - adaptive interface including humoral responses 20 NK cell and endothelial cell interactions 21 Natural killer cell/epithelial interactions 22 NK cell - T cell interactions Part III. NK cells in the tissues 23 NK cells and NKT cells in cutaneous disorders 24 Natural killer cells in the respiratory tract 25 Intestinal natural killer cells 26 Natural killer cells in the liver 27 Natural killer cells in the spleen and lymph node 28 Natural killer cells in the central nervous system 29 NK cells in the eye 30 NK cells and reproduction 31 Identification of natural killer cells in tissues and their isolation 32 Natural killer cell immune regulation: coordination of immune function in tissues Part IV. NK cells in disease 33 Natural killer cells and transplantation 34 Natural killer cells and autoimmunity 35 Interaction of NK cells with bacteria 36 Natural killer cells and human immunodeficiency virus 37 Cytomegalovirus infection and NK cells 38 Natural killer cells in allergy 39 Natural killer cells in wound healing 40 Natural killer cells in atherosclerosis 41 Natural killer cells in leukaemia 42 Natural killer cells and allogeneic haematopoietic cell transplantation 43 Clinical trials of NK cells for cancer 44 Natural killer cells and hepatitis C virus infection 45 Natural killer cells and the biology of parasitism 46 Lymphoproliferative disorders of natural killer cells Part V. Special topics in NK biology 47 Natural killer cell induction of tolerance 48 Genetic engineering of natural killer cells 49 NK cell-mediated target cell death 50 NK-cell tracking using non-invasive imaging modalities Subject Index Color Plate Section
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