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Toxoplasma Gondii

Toxoplasma Gondii, 2nd Edition

The Model Apicomplexan - Perspectives and Methods

Toxoplasma Gondii, 2nd Edition,Louis M. Weiss,Kami Kim,ISBN9780123964816


Academic Press




235 X 191

Reflects the significant advances of the field in the last 5 years, including new information on the genetics and genomics of Toxoplasma gondii and on the population biology and genetic diversity of this organism

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Key Features

  • Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen
  • Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis
  • Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists


This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.


Parasitologists, Cell and Molecular Biologists, Veterinarians and Veterinary Researchers, Neuroscientists, Research Clinicians, and Food Scientists

Louis M. Weiss

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Affiliations and Expertise

Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.

View additional works by Louis M. Weiss

Kami Kim

Kami Kim M.D. is Professor of Medicine (Division of Infectious Diseases), Professor of Pathology (Division of Parasitology and Tropical Medicine) and Professor of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, New York. Dr. Kim received her M.D. degree from Columbia College of Physicians and Surgeons in 1984. She trained in internal medicine at Columbia Presbyterian Medical Center and in infectious diseases at the University of California, San Francisco. Following her clinical training, she did a postdoctoral fellowship in the Department of Microbiology & Immunology at Stanford University School of Medicine, after which she joined the faculty at Einstein where she is currently a Professor of Medicine, Pathology and Microbiology and Immunology. Her laboratory research is focused upon understanding the pathogenesis of toxoplasmosis and malaria. Recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand the clinical impact of HIV co-infection upon cerebral malaria. She is also interested in understanding epigenetic and genetic factors that govern the host response to parasitic infections, opportunistic pathogens and tuberculosis. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America and an elected member of the Association for American Physcians and the American Society for Clinical Investigation.

Affiliations and Expertise

Professor of Medicine, Pathology, and Microbiology & Immunology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.

Toxoplasma Gondii, 2nd Edition

    1. The History and Life Cycle of Toxoplasma gondii
    2. The Ultrastructure of Toxoplasma gondii
    3. Population Structure and Epidemiology of Toxoplasma gondii
    4. Toxoplasma Clinical Disease and Diagnostics
    5. Ocular Disease
    6. Toxoplasmosis in Wild and Domestic Animals
    7. Toxoplasma Animal Models and Therapeutics
    8. Biochemistry, Lipids, Glycobiology and Metabolism of Toxoplasma gondii
    9. The Apicoplast and Mitochondrion of Toxoplasma gondii
    10. Calcium Storage and Homeostasis in Toxoplasma gondii
    11. The Parasitophorous Vacuole: an organelle for the host pathogen interface
    12. Toxoplasma Secretory Organelles: Rhoptries, Micronemes and Dense Granules
    13. The Cytoskelton: Structure and Motility
    14. Alterations in Host Cell Biology due to Toxoplasma gondii
    15. Bradyzoite Development
    16. Development and Application of Classical Genetics in Toxoplasma gondii
    17. Genetic Manipulation
    18. Gene Regulation and Epigenomics
    19. Genomic Analysis and Bioinformatics
    20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and other Apicomplexa
    21. Chemical Biology and Toxoplasma as a Model System for Drug Discovery
    22. Proteomics of Toxoplasma gondii
    23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences
    24. Innate Immunity in Toxoplasma Infection
    25. Adaptive Immunity and host Genetics
    26. Toxoplasma gondii vaccines
    Epilogue: Toxoplasma as a Model Organism

Quotes and reviews

"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." – Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio

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