Genetic Instabilities and Neurological Diseases, Second Edition

Genetic Instabilities and Neurological Diseases, Second Edition, 2nd Edition

Genetic Instabilities and Neurological Diseases, Second Edition, 2nd Edition,Robert D. Wells,Tetsuo Ashizawa,ISBN9780080463773

Wells   &   Ashizawa   

Academic Press



An updated review of the clinical, genetic, molecular, biological and biophysical investigations of neurological diseases.

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USD 280.00
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Key Features

* Includes a CD-ROM with all of the figures
* Contributions by most of the principal research teams in the area, edited by world-renowned leaders
* Lays the background for future investigations on related diseases


This book describes everything about DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides excellent updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This edition also features a CD-ROM containing all of the figures from the book. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students.


Neurologists, neuroscientists, biochemists, geneticists, biophysicists, cell biologists, molecular biologists, human geneticists, pathologists, cancer researchers, tumor biologists, researchers developing standards for disease analysis, and patient advocacy groups.

Robert D. Wells

Affiliations and Expertise

Texas A&M University, Houston, U.S.A.

Tetsuo Ashizawa

Quotes and reviews

Praise for the First Edition:
"...this presentation provides continued incentive to contribute to understanding the molecular foundation of each unique disease with the hope of insight and new strategies for treatment."
- Alan P. Wolfe, Chief, Laboratory of Molecular Embryology, National Institutes of Health

"... this is not a journey, it is an odyssey! ... the Wells and Warren book is outstanding. Here, the publishers deserve a pat on the back for the layout, figures (some of which are in colour) and print quality. I simply cannot praise this book enough. My copy will be jealously guarded!"
- Jamal Nasir, Department of Molecular Medicine, Western General Hospital, Edinburgh UK

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