The Mouse in Biomedical Research, 2nd Edition,James Fox,Stephen Barthold,Muriel Davisson,Christian Newcomer,Fred Quimby,Abigail Smith,ISBN9780123694584

392 Pages / 279 X 216



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Volume 4: The Mouse in Biomedical Research, 2nd Edition

Immunology

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Editor(s) : Fox  &   Barthold  &   Davisson  &   Newcomer  &   Quimby  &   Smith  

Published: 05 Dec 2006

Imprint: Academic Press

ISBN: 9780123694584

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Description

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

Readership

Veterinary and medical students, graduate students, post-docs, immunologists, and researchers who utilize animals in biomedical research

James Fox

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, U.S.A.

View additional works by James G. Fox

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

View additional works by Stephen Barthold

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

View additional works by Muriel Davisson

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

View additional works by Christian E. Newcomer

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

View additional works by Fred W. Quimby

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA

View additional works by Abigail Smith

The Mouse in Biomedical Research, 2nd Edition

Volume IV Immunology

1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook

2. The Biology of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira

3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumánovics

4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman

5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff

6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci

7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai

8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu

9. Mouse Models of Negative Selection
Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist

10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao

11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland

12. Inhibitory Receptors and Autoimmunity in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith

13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert

14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu

15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes
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