Key Features
Over 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition
Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics
Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine
Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Description
With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003.
Genomic and Personalized Medicine 2nd edition is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine.
Readership
Specialists across medical disciplines, research professionals in human genetics/genomics, oncology, neuroscience, gene therapy, molecular medicine, and related areas. It will be indispensable to medical students and graduate students in genetics and biomedical sciences.
Genomic and Personalized Medicine, 2nd Edition
Part I. Genome-Based Approaches to Biology and Medicine
Principles of Human Genomics
1. Organization, Variation and Expression of the Human Genome
2. Mapping the Funcational Genome: The ENCODE and Roadmap Epigenomics Projects
3. Population Perspectives on Genome Variation and Complex Disease
4. Gene-Environment Interactions: Eco-genetics and Toxicogenomics
5. Systems Biology and Systems Medicine
Genome-Based Approaches for Genomic and Personalized Medicine
6. Personal Genomics
7. Whole genome sequencing: new technologies, approaches, applications
8. Human Genome Variation Discovery via Exome and Whole-Genome Sequencing
9. Clinical Genome Sequencing
10. Structural Genomic Variation in the Human Genome
11. Clinical applications of whole-genome chromosomal microarray analysis
12. Transcriptomics in the age of ultra high-throughput sequencing
13. Quantitative Proteomics in Genomic Medicine
14. The Human Microbiome and Personalized Medicine
15. Glycomics, glycobiology, glycomedicine
16. Genome-wide RNA Interference Screening
Part II. Translational Approaches in Genomic and Personalized Medicine
Enabling Genomic Strategies, Clinical Research, and Informatics Platforms for Genomic and Personalized Medicine
17. Application of Human Genome Information to Clinical Practice
18. Genomic and Personalized Medicine and Public Health View
19. Biospecimen Banking in the Post Genome Era
20. Designing Genome-Based Clinical Studies
21. Genomic Biomarkers in Human Population Studies
22. Validating Candidate Protein Biomarkers
23. Translational Bioinformatics for Genomic Medicine
24. Electronic Health Records and Genomic Medicine
25. Clinical Implementation of Genomic Medicine in Primary Care
26. Health Risk Assessment and Family History
27. Clinical Decision Support
28. Knowledge Management in Personalized Health Care
29. Integration into Healthcare Systems
30. Pharmacogenomics in Drug Discovery and Development
31. Pharmacogenetics and Pharmacogenomics
32. Point of Care Devices
33. Patient-specific Pluripotent Stem Cells
Policy Challenges in Genomic and Personalized Medicine
34. Overview of Policy, Ethical and Social Considerations
35. Informed Consent
36. Educational Issues and Strategies for Genomic Medicine
37. Regulation of Genomic Technologies
38. Challenges and Regulation of Direct to Consumer Genetic Testing
39. Economics of Genomic Medicine
40. trategies in the Adoption of Genome-Based Diagnositics
41. Reimbursement
42. Impact of Patents on Genomic Medicine
43. Public-Private Partnerships in Biomarker Discovery and Development
Part III. Disease-Based Genomic and Personalized Medicine: Genome Discoveries & Clinical Significance
Cardiovascular Genomic Medicine
44. Hypertension
45. Lipoprotein Disorders
46. Coronary Artery Disease and Myocardial Infarction
47. The Vulnerable Plaque and Acute Coronary Syndromes
48. Heart Failure
49. Cardiac Transplant Rejection
50. Hypertrophic Cardiomypoathies
51. Arrhythmias
52. Hemostasis and Thrombosis
53. Peripheral Afterial Disease
54. Congenital Heart Disease
55. Perioperative Genomics
56. Stroke
Oncology Genomic Medicine
57. Lymphomas
58. Leukemias
59. Genomics of Lung Cancer
60. Breast Cancer
61. Ovarian Cancer
62. Colorectal Cancer
63. Prostate Cancer
64. Head and Neck Cancer
65. Brain Tumors and Gilomas
66. Melanoma
67. Metastatic Cancer
68. Bioinformatics and Personalized Cancer Care
69. Diagnostic-Therapeutic Combinations
Inflammatory and Metabolic Disease Genomic Medicine
70. Autoimmune Disorders
71. Rheumatoid Arthritis
72. Multiple Sclerosis
73. Inflammatory Bowel Disease
74. Asthma
75. Chronic Obstructive Pulmonary Disease
76. Interstitial Lung Disease
77. Peptic Ulcer Disease
78. Cirrhosis
79. System Sclerosis
80. Lupus
81. Osteoarthritis
82. Diabetes Genomics
83. The Metabolic Syndrome
Neuropsychiatric Disease Genomic Medicine
84. Overview of Neuroscience and Genomics
85. Alzheimers Disease
86. Parkinson's Disease
87. Epilepsy
88. Schizophrenia and Bipolar Disorder
89. Depression
90. Autism
91. Overview of Eye Disease and Genomics
92. Glaucoma
Infectious Disease Genomic Medicine
93. Diagnosis and Classification of Pathogens
94. Host-Pathogen Interactions
95. Microbial Vaccine Development
96. Bacterial Infections
97. Emerging Viral Infections
98. Sepsis
99. Viral Hepatitis
100. Malaria
101. HIV Pharmacogenetics and Pharmacogenomics
