Handbook on the Toxicology of Metals

Handbook on the Toxicology of Metals, 3rd Edition

Handbook on the Toxicology of Metals, 3rd Edition,Monica Nordberg,Gunnar Nordberg,Bruce Fowler,Lars Friberg,ISBN9780123694133

Nordberg   &   Nordberg   &   Fowler   &   Friberg   

Academic Press

9780123694133 New edition



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Key Features

* Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter
* New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more


Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds.


Toxicologists, physicians, and engineers in the fields of environmental and occupational health as well as libraries in these disciplines. Will also be a useful reference for governmental regulatory agencies and public health officers.

Monica Nordberg

Dr Monica Nordberg, Ph.D. is an emerita Professor at Karolinska Institutet (KI), Institute of Environmental Medicine, Stockholm, Sweden. She has served as chair of the Department of Environmental Hygiene, as member, Karolinska Institutet Study Program for Community Medicine, member of Education Policy Committee for Toxicology and Public Health, KI, Stockholm for many years. She has published 175 scientific articles, book chapters and review articles dealing with biochemical mechanisms and health effects related to exposure to metals mainly cadmium, lead and mercury and interaction with selenium. She is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest (3:rd) Edition 2010. Monica Nordberg is a co- editor and author, of the Handbook on the Toxicology of Metals 3rd edition, Academic Press/Elsevier, 2007 and, for the new 4th edition 2015. This work is within the framework of Scientific Committee on the Toxicology of Metals under International Commission on Occupational Health (SCTM/ICOH) which she served as secretary, chair and presently as former chair. She served as titular member of the Chemistry and Human Health of International Union of Pure and Applied Chemistry issuing recommendations regarding definitions and concepts. She was the Swedish representative in the Management Committee of COST Action, member EU Strategy Environment and Health, SCALE, Technical Working Group Indicators and Priority Diseases. She has experience as an expert serving Japan Food Safety Agency, US Environmental Protection Agency, National Institute for Environmental Health Studies (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety. Monica Nordberg is a full member of different societies such as Society of Toxicology, USA.

Affiliations and Expertise

PhD, Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden

Gunnar Nordberg

Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a scientist at the International Agency for Research on Cancer, Lyon, France and as a Professor and chairman at the Department of Environmental Medicine, Odense University, Denmark. He has published more than 270 papers in Scientific Journals and International Handbooks. In addition, he edited or co-edited 23 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents which resulted in 25 international books. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest (3rd) Edition 2010. Chief Editor, Handbook on the Toxicology of Metals, 3rd Ed, published 2007 by Academic Press/Elsevier, new 4th edition publishing October 2014. He has extensive experience as an expert serving Swedish and International Authorities such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute for Environmental Health Studies (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety; International Agency for Research on Cancer IARC, Lyon, France, World Health Organization, Europe/European Environment Agency, Copenhagen; European Food Safety Authority (EFSA), Parma, Italy.

Affiliations and Expertise

Umeå University, Department of Public Health and Clinical Medicine, Sweden

Bruce Fowler

Dr. Bruce A. Fowler Ph.D., A.T.S is currently a consultant and an Adjunct Professor at Emory University in Atlanta, Georgia, and a Presidents Professor of Biomedical Research at the University of Alaska- Fairbanks. He has previously held positions as a Senior Fellow/Expert Consultant at ICF International, Associate Director for Science in the Division of Toxicology and Environmental Medicine at ATSDR, Director of the System-wide Program in Toxicology at the University of Maryland and Senior Scientist at the NIEHS. He has been previously selected as a Fellow of the Japanese Society for the Promotion of Science (JSPS), Fulbright Scholar and Swedish Medical Research Council Visiting Professor at the Karolinska Institute in Stockholm Sweden. He has chaired and served on a number of national / international committees in the area of metal toxicology including those of the National Academies of Science, WHO, IARC, National Institutes of Health, and USEPA. Dr. Fowler is the author of over 260 research papers and book chapters dealing with molecular mechanisms of metal toxicity and molecular biomarkers for early detection of metal-induced cell injury. He has been the editor or co-editor of 7 books or monographs on metal toxicology, mechanisms of chemical - induced cell injury and computational toxicology. His current research is focused on computational toxicology and the application of molecular biomarkers for risk assessments of chemical mixtures involving metals, particularly in relation to binary semiconductor materials such as gallium arsenide, indium arsenide as well as lead, cadmium, and arsenic mixtures. He has received a number of awards for his research including a Society of Toxicology Colgate-Palmolive Visiting Professorship in In Vitro Toxicology to the University of Washington and CDC National Center for Environmental Health/ATSDR awards including the Honor Award for Excellence in Quantitative Sciences- Cadmium PbPK Modeling Group Award, NCEH/ATSDR Honor Award for Excellence in Emergency Response Deepwater Horizon Oil Spill Response Team (Domestic) Group Award. As a member of the elemental impurities panel, Dr. Fowler has also received the 2014 USP Award for an Innovative Response to Public Health Challenges (Group Award). He serves on the editorial boards of a number of scientific journals in toxicology and is currently an Associate Editor of Environmental Health Perspectives and Toxicology and Applied Pharmacology.

Affiliations and Expertise

Ph.D., A.T.S., Private Consulting Toxicologist, Adjunct Professor, Emory University, Rollins School of Public Health, and Presidents Professor of Biomedical Research, University of Alaska - Fairbanks

View additional works by Bruce A. Fowler

Lars Friberg

Affiliations and Expertise

Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden

Handbook on the Toxicology of Metals, 3rd Edition

Introduction - General Considerations and International Perspectives
General Chemistry, Sampling, Analytical Methods and Speciation
Routes of Exposure, Dose, and Metabolism of Metals
Biological Monitoring and Biomarkers
Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity
General Considerations of Dose-Effect and Dose-Response Relationships
Interactions in Metal Toxicology
Epidemiological Methods for Assessing Dose-Response and Dose-Effect Relationships
Essential Metals: Assessing Risks from Deficiency and Toxicity
Carcinogenicity of Metal Compounds
Immunotoxicology of Metals
Reproductive and Developmental Toxicity of Metals
Ecotoxicology of Metals - Sources, Transport, and Effects in the Ecosystem
Risk Assessment
Diagnosis and Treatment of Metal Poisoning - General Aspects
Principles for Prevention of the Toxic Effects of Metals
Gallium and Semiconductor Compounds

Quotes and reviews

"The handbook is a weighty collection of 47 essays in the fields of toxicology and ecology of metals, reflecting a wide range of specialist knowledge from authors of several parts of theworld. It promotes awareness of health threats of the general public as well as of professionals in various occupations, constituting a valuable reference source for physicians, toxicologists, scientists in several areas, legislators and managers of environmental and occupational safety organizations. The scope of the handbook is wide and multidisciplinary, integrating human and environmental ecology. It is desireable that the handbook will find its way to many bookshelves at hospitals, industrial and governmental libraries
and several research institutes in every part of the world."
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