Laboratory Animal Anaesthesia, 4th Edition

Laboratory Animal Anaesthesia, 4th Edition,Paul Flecknell,ISBN9780128000366
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A basic guide to anaesthesia for a diverse audience needing straight-forward, structured content

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Key Features

  • Written by a veterinary anesthetist and scientist with over 30 years' experience in the field, and who is actively engaged in research in this area
  • Focuses on procedures involving rats and mice used in research
  • Provides those with limited experience of anesthesia with the information they need to carry our procedures effectively, safely, and humanely, as well as those with more experience to continue a career with laboratory animal model research
  • Includes rapid, easily accessed information using tabulated summaries


Laboratory Animal Anaesthesia, Fourth Edition provides a basic guide to anaesthesia for a very diverse audience needing content, with straight-forward, structured style of writing. Updated with effects of anaesthetics in different laboratory species, including sources of dose rates will be incorporated into tabular material. New information on pain assessment and pain management will be covered, and an increased emphasis on rats and mice for anaesthesia and perioperative care. With newly revised, full color illustrations to facilitate best learning, Laboratory animal Anesthesia, Fourth Edition provides procedures, key points and invaluable advice from a well-known and respected veterinary anesthetist and scientist with over 30 years of experience in the field.


Researchers, graduate students and veterinarians in all fields across biological and biomedical research, animal technicians, animal care staff, veterinary anaesthetists, and veterinarians

Paul Flecknell

Paul Flecknell is a veterinarian with over 35 years of experience working with laboratory animals. He is a Diplomate of the European Colleges of Veterinary Anaesthesia and Analgesia and Laboratory Animal Medicine and an honorary Diplomate of the American College of Laboratory Animal Medicine. He has PhD in physiology, and is currently Professor of Laboratory Animal Science in the Institute of Neuroscience at Newcastle University. His main research interests are anaesthesia and analgesia of all species of animals and in particular the development of methods of pain assessment. He is the head of the Pain and Animal Welfare Science (PAWS) group at Newcastle. The group’s current research work is focussed on novel methods of “cage-side” assessment of pain, particularly using “pain faces” and developing methods of measurement of affective state in rodents.

Affiliations and Expertise

Comparative Biology Centre, The Medical School, Newcastle-Upon-Tyne, UK

Laboratory Animal Anaesthesia, 4th Edition

  • Preface
  • Preface to the Third Edition
  • Preface to the Second Edition
  • Preface to the First Edition
  • Glossary
  • List of Tables
  • List of Figures
  • Acknowledgements
  • Introduction
  • Chapter 1. Basic Principles of Anaesthesia
    • Introduction: What is Anaesthesia and How Do We Produce it?
    • Anaesthetic Equipment – Preparation and Use
    • Intranasal Intubation
    • Administration of Anaesthetics by Injection
    • Preparations for Anaesthesia – People and Animals
    • Anaesthetic Agents
    • Inhalational Anaesthetic Agents
    • Injectable Anaesthetic Agents
    • Selection of Anaesthetic Agents – Scientific and Welfare Considerations
  • Chapter 2. Managing and Monitoring Anaesthesia
    • Pre-operative Preparations
    • Monitoring Anaesthesia
    • Anaesthetic Problems and Emergencies
  • Chapter 3. Special Techniques
    • Use of NMB Agents
    • Controlled Ventilation
    • Long-Term Anaesthesia
    • Anaesthesia of Pregnant Animals
    • Anaesthesia of Neonates
    • Anaesthesia for Imaging
  • Chapter 4. Analgesia and Post-Operative Care
    • The Recovery Room Environment
    • Problems During the Recovery Period
    • Management of Post-Operative Pain
    • Pain Assessment
    • Pain Relief
    • Conclusions
  • Chapter 5. Anaesthesia of Common Laboratory Species: Special Considerations
    • Small Rodents
    • Rabbits
    • Post-Operative Care
    • Cats
    • Dogs
    • Ferrets
    • Pigs
    • Sheep and Goats
    • Primates
    • Other Species
  • Appendix 1. Recommended Techniques and Physiological Data. When No Injectable Anaesthetic Is Recommended, Inhalational Agents Should Be Used
  • Appendix 2. Estimation of Required Quantities of Volatile Anaesthetics and Anaesthetic Gases
  • Appendix 3. Examples of Dilutions of Anaesthetic Mixtures for Small Rodents
    • Rat
    • Mouse
    • Guinea-Pig
    • Birds
  • Appendix 4. Manufacturers of Equipment and Other Items Illustrated or Cited in the Text
  • Bibliography
  • Index

Quotes and reviews

"The preeminent book on laboratory animal anesthesia and analgesia...It is easy to locate information in this one-stop resource on laboratory animal anesthesia...a well organized book that ensures readers are aware of the most important clinical aspects of a topic. Score: 99 - 5 Stars"--Doody's,Laboratory Animal Anaesthesia, Fourth Edition

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