Platelets, 3rd Edition

Platelets, 3rd Edition,Alan Michelson,ISBN9780123878373

A Michelson   

Academic Press




276 X 216

Winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine

Print Book + eBook

USD 297.60
USD 496.00

Buy both together and save 40%

Print Book


In Stock

Estimated Delivery Time
USD 250.00

eBook Overview

VST (VitalSource Bookshelf) format

DRM-free included formats : EPUB, Mobi (for Kindle), PDF

USD 246.00
Add to Cart

Key Features

  • Highly Commended BMA Medical Book Award 2013: Internal Medicine
  • Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists
  • Integrates the entire field of platelet biology, pathophysiology, and clinical medicine
  • Full color reference comprising 64 chapters, 1400 pages, and 16,000 references
  • Contributions from 126 world leaders in their fields
  • New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo


Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.


Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields

Alan Michelson

Dr. Alan D. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts. He is also the Director of the Center for Platelet Research Studies and the Director of the Thrombosis Program and Anticoagulation Service at Children's Hospital Boston. After receiving his medical degree with honors from the University of Adelaide, Australia in 1974, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Children’s Hospital Boston, Brigham and Women’s Hospital, and Harvard Medical School. He has been the principal investigator on approximately 100 research grants and has published over 400 original research articles, original research abstracts, and invited reviews. Dr. Michelson has been an invited speaker at over 180 major medical conferences worldwide and has been an invited participant at numerous national and international consensus conferences and workshops, including Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. He is the inventor on two U.S. patents.

Affiliations and Expertise

Harvard University Medical School, Boston, MA, USA

Platelets, 3rd Edition

A Brief History of Ideas About Platelets in Health and Disease / Barry S. Coller

Part One: Platelet Biology
1. The Evolution of Mammalian Platelets / Jack Levin
2. Megakaryocyte Development and Platelet Formation / Joseph E. Italiano Jr.
3. The regulation of platelet life span / Benjamin T. Kile
4. Platelet Genomics / Willem Ouwehand, Paul F. Bray
5. Platelet MicroRNAs / Patrick Provost
6. The Platelet Proteome / Andrew S. Weyrich
7. Platelet Structure / James G. White
8. The Platelet Cytoskeleton / John H. Hartwig
9. Platelet Receptors / Kenneth J. Clemetson
10. The GPIb-IX-V Complex / Michael C. Berndt
11. GPVI and CLEC-2 / Steve P. Watson, Alice Y. Pollitt, Craig E. Hughes
12. Integrin AlphaIIb Beta3 / Edward F. Plow
13. Protease-activated Receptors / Athan Kuliopulos, Ping Zhang, Lidija Covic
14. The Platelet P2 Receptors / Marco Cattaneo
15. PECAM-1 / Peter J. Newman, Debra Newman
16. Interactions Between Platelets, Leukocytes and the Endothelium / Susan S. Smyth
17. Inhibition of Platelet Function by the Endothelium / Jane E. Freedman
18. Platelet Secretion / Robert Flaumenhaft
19. Signal Transduction During Platelet Plug Formation / Lawrence F. Brass
20. Platelet Thrombus Formation in Flowing Blood / Zaverio M. Ruggeri
21. Interactions Between Platelets and the Coagulation System / Paula B. Tracy
22. Platelet-Derived Microparticles / Rienk Nieuwland
23. The Role of Platelets in Fibrinolysis / Nicola J. Mutch
24. The Role of Platelets in Angiogenesis / Giannoula Lakka Klement, Ela Shai, David Varon
25. Platelet Function in the Newborn / Sara J. Israels

Part Two: Tests of Platelet Function
26. Clinical Tests of Platelet Function / Paul Harrison
27. Platelet Counting / Paul Harrison
28. Platelet Aggregation / Catherine Pauline Hayward, Karen A. Moffat
29. Flow Cytometry / Alan D. Michelson
30. Monitoring of Antiplatelet Therapy / Paul A. Gurbel, Udaya S. Tantry
31. Real Time In Vivo Imaging of Platelets During Thrombus Formation / Bruce Furie, Barbara Furie

Part Three: The Role of Platelets in Disease
32. Atherothrombosis and Coronary Artery Disease / Meinrad Gawaz
33. Central Nervous System Ischemia / Gregory J. del Zoppo
34. Peripheral Vascular Disease / Michael Sobel
35. Diabetes Mellitus / Giovanni Davi
36. Inflammation / Guy Zimmerman
37. Antimicrobial Host Defense / Michael R. Yeaman, Arnold Bayer
38. Tumor Growth and Metastasis / Jerry Ware

Part Four: Disorders of Platelet Number and Function
39. The Clinical Approach to Disorders of Platelet Number and Function / Alan D. Michelson
40. Immune Thrombocytopenia (ITP) / James B. Bussel, Bethan Psaila
41. Drug-induced Thrombocytopenia / Richard H. Aster
42. Heparin-induced Thrombocytopenia / Andreas Greinacher, Theodore Warkentin, Beng H. Chong
43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome / Han-Mou Tsai
44. Thrombocytopenia in Pregnancy / Keith R. McCrae
45. Thrombocytopenia in the Newborn / Irene A.G. Roberts
46. Alloimmune Thrombocytopenia / Cecile Kaplan, Heyu Ni, John Freedman
47. Inherited Thrombocytopenias / Mortimer Poncz, Michele P. Lambert and Ravichandran Mohan
48. Pseudothrombocytopenia / Nicola Bizzaro
49. Thrombocytosis and Essential Thrombocythemia / Ayalew Tefferi
50. Congenital Disorders of Platelet Function / Marco Cattaneo
51. Acquired Disorders of Platelet Function / A. Koneti Rao
52. Cardiopulmonary Bypass / Brian Richard Smith, Henry M. Rinder, Christine S. Rinder

Part Five: Antiplatelet Therapy
53. Aspirin / Carlo Patrono
54. ADP Receptor Antagonists / Marco Cattaneo
55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists / Anthony A. Bavry
56. Dipyridamole / Wolfgang G. Eisert
57. Cilostazol / Yasuo Ikeda, Toshiki Sudo
58. Novel Antiplatelet Therapies / Deepak L. Bhatt

Part Six: Therapy to Increase Platelet Numbers and/or Function
59. Thrombopoietin Mimetics / David J. Kuter
60. Desmopressin / Pier Mannuccio Mannucci
61. Factor VIIa / Man-Chiu Poon
62. Platelet Transfusion Medicine / Peter L. Perrotta, Jeremy Parsons, Henry M. Rinder, Edward L. Snyder
63. Making Platelets Ex Vivo / Mortimer Poncz, Spencer Sullivan, Michele P. Lambert
64. Gene Therapy for Platelet Disorders / David A. Wilcox

Quotes and reviews

"Platelets fills an important niche on the bookshelf of any academic hematologist. The user-friendly online access to the figures contained in the textbook will be especially useful for teaching purposes…this encyclopedia of the platelet contains critical information for physicians, educators, students, and research scientists.", January 29, 2014

Reviews of the Third Edition:

"Comprehensive and definitive, this third-edition reference integrates platelet biology, pathophysiology, and clinical medicine. Sixty-four chapters address biology, function, disease, disorders of platelet number or function, antiplatelet therapy, and therapy to increase numbers and/or function."--Reference and Research Book News, August 2013

"I've been reading various chapters for the past few days and have been marveling at the sheer depth and breadth. No other textbook or other reference source is comparable…You must have this book if your practice or interest even superficially touches on platelets.", June 21, 2013

"Platelets is the definitive current source of state- of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine.", April 24, 2013

"One might well question the value of a doorstopper-sized textbook in this era of instant Internet access to all variety of even the most arcane information. A notable exception, however, is the third edition of Michelson’s Platelets. The surprising complexity of these anucleate cells and their diverse and ever enlarging roles in physiology and disease has attracted a large cadre of interdisciplinary researchers focused on various aspects of these roles. Having at ready hand a readable, authoritative, comprehensive and beautifully illustrated and cross-referenced volume makes for easy access to important information required by these researchers - both established senior investigators and their students."--Thomas P Stossel, MD, American Cancer Society Professor of Medicine Harvard Medical School Director, Translational Medicine Unit and center for Medical Innovation Senior Physician, Hematology Division Brigham & Women's Hospital, Boston, MA, USA


Reviews of the SECOND EDITION

"...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells."
-Journal of the American Medical Association

"This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research."

"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too."
- Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars)

Reviews of the FIRST EDITION

landmark…a useful, comprehensive reference"
- New England Journal of Medicine (2003)

"belongs on the bookshelf of every clinician who assesses patients with platelet disorders"
- The Lancet (2003)

"arguably the most complete compendium available on the subject that was once regarded as merely 'blood dust'."
- British Journal of Haematology (2003)

"a single-handed compilation of authoritative material"
- Transfusion (2003)

"a modern encyclopedia...stands out as the most comprehensive and up-to-date review of platelets yet published."
- Journal of Vascular Surgery (2003)

"beautifully organized"
- American Journal of Clinical Pathology (2003)

"...a must have for the shelf of physicians and scientists with more than a passing interest in platelet pathophysiology."

"...most up-to-date comprehensive standard work, which provides a superb reference for everyone interested in platelets."

"If you have no time to waste then Platelets is the book for you."
-ARCH PATHOL LAB MED (November 2003)

"...comprehensive compendium that is one of the first to appear on this important subject in more than a decade..."

"A hefty, comprehensive reference comprising 61 contributed chapters on those small cells with big roles."
-SCITECH BOOK NEWS (December 2002)

"Without a doubt, the text will serve as a definitive resource for years to come."

"The material is of self sufficient quality and scope that many chapters will retain their value for years to come."

Free Shipping
Shop with Confidence

Free Shipping around the world
▪ Broad range of products
▪ 30 days return policy

Contact Us