@bul:* Includes much new data on this fast-moving field, including newly discovered oncogenes
* Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes
* Contains more than 2000 terms for reference and further research
* Revised to included signaling pathways, apoptosis, and metastasis
The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy.
The Oncogene & Tumour Suppressor Gene Factsbook, 2nd Edition
The Introductory Chapters:
Introduction: Identification of Oncogenes.
Oncogene Activation in Humans.
Proliferation Control Pathways: Oncoprotein Function.
Growth Factor-Related Proteins.SRC. RAS
Nuclear Oncoproteins.ETS. FOS
and JUN. MYB. MYC. REL. ERBA
Tumour Suppressor Genes: RB1. P53
Other Major Tumour Suppressor Genes.APC. BRCA1. NF1. VHL. WT1
Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs
Apoptosis: Tumour Suppressor Genes and Apoptosis.
Angiogenesis and Metastasis: Angiogenesis.
Metastasis: Correlations with Gene Expression.
The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM
Matrix Metalloproteinases (MMPS).
Tissue Inhibitors of Metalloproteinases (TIMPs).
Cysteine and Aspartic Proteinases and Heparanase.
NME1 and NME2.
The Multi-step Nature of Cancer: Cervical Carcinoma.
Renal Cell Carcinoma.
Chronic Myeloid Leukemia.
Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.
Tumour Suppressor Gene Therapy.
Cytokine Gene Therapy and Tumour Vaccination.
Virally Directed Enzyme Prodrug Therapy (VDEPT).
Oncogenes Transduced by Retroviruses.
Oncogenes Activated by Retroviral Insertion.
Oncogenes at Chromosomal Translocations.
Tumour Suppressor Genes Detected in Human Tumours.
Functions of Oncoproteins.
Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.The Oncogenes:ABL. AKT1
and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1
and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1
and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1
and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2
and WNT3. YES1
.Tumour Suppressor Genes:APC
and MCC. BRCA1
and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP
and MLHL. NF1
and NF2. P53, PTC
.The Retinoblastoma Gene (RB1). TGFBR1
and TGFBR2. VHL; WT1
.Cyclin-dependent Kinase Inhibitors:INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2.
and INK4D. KIP1. KIP2. WAF1
.DNA Tumour Viruses:
Quotes and reviews
@qu:"Within minutes of receiving my review copy of The Oncogene FactsBook I discovered just how useful it could be... I could have found the information I needed in a matter of seconds. There is no doubt that every lab working on oncogenes or growth control should have a copy of this book for reference."
@source:--TRENDS IN BIOCHEMICAL SCIENCES
@from:Praise for the First Edition
@qu:"The introductory chapters on genes and the processes involved in cancer development are very good for undergraduate teaching."
@source:--Nicholas R. Lemoire in MOLECULAR MEDICINE TODAY