GTPases Regulating Membrane Targeting and Fusion

GTPases Regulating Membrane Targeting and Fusion, 1st Edition

GTPases Regulating Membrane Targeting and Fusion, 1st Edition,W. Balch,Channing Der,Alan Hall,ISBN9780121828080

Methods in Enzymology

Balch   &   Der   &   Hall   

Academic Press



229 X 152

Print Book


In Stock

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USD 225.00

Key Features

* Comprehensive overview of Rab GTPase phylogeny and systems biology
* Identification and characterization of Rab GEFs, GAPs and effectors
* General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches


Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors.

Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation.


Biochemists, biophysicists, cell biologists, molecular biologists, geneticists, developmental biologists.

W. Balch

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA

View additional works by W. E. Balch

Channing Der

Affiliations and Expertise

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA

View additional works by Channing J. Der

Alan Hall

Affiliations and Expertise

University College of London, U.K.

View additional works by Alan Hall
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