Protein NMR Spectroscopy, 2nd Edition

Principles and Practice

Protein NMR Spectroscopy, 2nd Edition,John Cavanagh,Wayne J. Fairbrother,Arthur G. Palmer, III,Nicholas J. Skelton,Mark Rance,ISBN9780121644918

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Academic Press




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Key resource for NMR Spectroscopy!

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Key Features

· Provides an understanding of the theoretical principles important for biological NMR spectroscopy
· Demonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experiments
· Allows for the capability of designing effective experimental protocols for investigations of protein structures and dynamics
· Includes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods


Protein NMR Spectroscopy combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution. Beginning with simple theoretical models and experimental techniques, Protein NMR Spectroscopy develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.

Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. The second edition includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.

Protein NMR Spectroscopy is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or who wish to understand the latest developments in this field.


Graduate students, postdoctoral fellows, established researchers interested in structural biology

John Cavanagh

Affiliations and Expertise

North Carolina State University, Raleigh, NC 27695

Wayne J. Fairbrother

Affiliations and Expertise

Genentech, Inc., San Francisco, CA 94080-4990

Arthur G. Palmer, III

Affiliations and Expertise

Columbia University, New York, NY 10032-3702

Nicholas J. Skelton

Affiliations and Expertise

Genentech, Inc., San Francisco, CA 94080-4990

Mark Rance

Affiliations and Expertise

University of Cincinnati, Cincinnati, OH 45267-0524

Protein NMR Spectroscopy, 2nd Edition

Preliminary Table of Contents
1. Classical NMR Spectroscopy
2. Theoretical Description of NMR Spectroscopy
3. Experimental Aspects of NMR Spectroscopy
4. Multi-Dimensional NMR Spectroscopy
5. Relaxation and Dynamic Processes
6. Experimental 1H NMR Methods
7. Heteronuclear NMR Experiments
8. Experimental NMR Relaxation Methods
9. Larger Proteins and Molecular Interactions
10. Sequential Assignment, Structure Determination and Other Applications

Quotes and reviews

"This volume is a comprehensive introduction to the methodology required for NMR studies of proteins." @source:JOURNAL OF MAGNETIC RESONANCE

"Protein NMR Spectroscopy: Principles and Practice covers a huge range of topics related to NMR....A fine two-semester course could be built on this very thorough book. Any student currently using NMR could benefit from the Cavanagh et al. text, which provides an in-depth explanation that is suitable as a resource for even a knowledgeable spectroscopist."

"All in all, I find the book very, very good. It will fill an important void in the literature/material available in the NMR field.....There are many 'hands on' secrets that will be very valuable to those beginning in the field as well as those who are 'old hands.' It has a distinct advantage over other books in that is was written as a whole, freshly from cover to cover; it is NOT a collection of published articles hurriedly put together with a nice binding."

"Along with detailed explanations of the mechanisms underlying the modern NMR experiments, the book also brings some "order" to the bewildering array of novel NMR pulse sequences. To practitioners of biomolecular NMR, it will prove invaluable for years to come."
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