The Enzymes

The Enzymes, 1st Edition

Protein Methyltransferases

The Enzymes, 1st Edition,Fuyuhiko Tamanoi,Steven Clarke,ISBN9780121227258

The Enzymes

Tamanoi   &   Clarke   

Academic Press




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Part of: The Enzymes



Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.


Biochemists, cell biologists, molecular biologists, biophysicists, and microbiologists

Fuyuhiko Tamanoi

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.

Affiliations and Expertise

University of California, Los Angeles, USA

View additional works by Fuyuhiko Tamanoi

Steven Clarke

Affiliations and Expertise

Department of Chemistry and Biochemistry, University of California Los Angeles, USA

The Enzymes, 1st Edition

The Enzymes, Volume 24 Table of Contents
Protein methyltransferases

Part I: Overview of Protein Methyltransferases

1. Protein methyltransferases: Their distribution among the five structural classes of AdoMet-dependent methyltransferases

Part II: Modification of Lysine and Arginine Residues in Signal Transduction, Transcription Translation, and Other Functions

2. The family of protein arginine methyltransferases
3. Diverse roles of protein arginine methyltransferases
4. Structure of protein arginine methyltransferases
5. Methylation and demethylation of histone Arg and Lys residues in chromatin structure and function
6. Structure of SET domain protein lysine methyltransferases
7. Non-histone protein lysine methyltransferases - structure and catalytic roles
8. Demethylation pathways for histone methyllysine residues

Part III: Biological Regulation by Protein Methyl Ester Formation

9. Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt), a key enzyme in CaaX processing
10. Genetic approaches for understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins
11. Reversible methylation of protein phosphatase 2A
12. Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems

Part IV: Recognition of Damaged Proteins in Aging by Protein Methyltransferases

13. Protein L-isoaspartyl, D-aspartyl O-methyltransferases:
catalysts for protein repair

Part V: Modification of Proteins by Methylation of Glutamine and Asparagine Residues

14. Modification of glutamine residues in proteins involved in translation
15. Modification of phycobiliproteins at asparagine residues

Part VI: Inhibition of Metyltransferases by Metabolites

16. Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary SAMe?
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