Co- and Posttranslational Proteolysis of Proteins

Co- and Posttranslational Proteolysis of Proteins, 3rd Edition

Co- and Posttranslational Proteolysis of Proteins, 3rd Edition,Ross Dalbey,David Sigman,ISBN9780121227234

The Enzymes

Dalbey   &   Sigman   

Academic Press




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Part of: The Enzymes



This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes.


Biochemists, Cell Biologists, Molecular Biologists, Biophysicists, and Microbiologists.

Ross Dalbey

Affiliations and Expertise

Ohio State University, Columbus, U.S.A.

View additional works by Ross Dalbey

David Sigman

Affiliations and Expertise

University of California School of Medicine, Los Angeles, California, U.S.A.

View additional works by David S. Sigman

Co- and Posttranslational Proteolysis of Proteins, 3rd Edition


Signal Peptide Processing:
The Eubacterial Lipoprotein-Specific (Type II) Signal Peptidase.
Bacterial Type I Signal Peptidases.
Structure and Function of the Endoplasmic Reticulum Signal Peptidase Complex.
Mitochondrial Processing Peptidase/Mitochondrial Intermediate Peptidase.
Chloroplast and Mitochondrial Type I Signal Peptidases.
Type IV Prepilin Leader Peptidases.

The Prohormone Convertases and Precursor Processing in Protein Biosynthesis.
Cellular Limited Proteolysis of Precursor Proteins and Peptides.
Yeast Kex2 Protease.
The Enzymology of PC1 and PC2.

Other Proteases That Cleave Proteins:
Self-Processing of Subunits of the Proteasome.
Tsp and Related Tail-Specific Proteases.
Co- and Posttranslational Processing: The Removal of Methionine.
Carboxypeptidases E and D.

Author Index.
Subject Index.
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