@bul:* The enzymatic mechanisms of protein lipidation
* Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase
This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.
Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists.
Protein Lipidation, 3rd Edition
Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey
Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese
Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi
Farnesyltransferase Inhibitors, J.B. Gibbs
Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb
Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke
Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder
Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon