Protein Lipidation

Protein Lipidation, 3rd Edition

Protein Lipidation, 3rd Edition,Fuyuhiko Tamanoi,David Sigman,ISBN9780121227227

The Enzymes

Tamanoi   &   Sigman   

Academic Press




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Part of: The Enzymes


Key Features

@introbul:Key Features
@bul:* The enzymatic mechanisms of protein lipidation
* Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase


This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.


Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists.

Fuyuhiko Tamanoi

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.

Affiliations and Expertise

University of California, Los Angeles, USA

View additional works by Fuyuhiko Tamanoi

David Sigman

Affiliations and Expertise

University of California School of Medicine, Los Angeles, California, U.S.A.

View additional works by David S. Sigman

Protein Lipidation, 3rd Edition

Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey.
Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese.
Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi.
Farnesyltransferase Inhibitors, J.B. Gibbs.
Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb.
Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra.
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke.
Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder.
Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon.
Chapter References.
Author Index.
Subject Index.
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