Models of Seizures and Epilepsy

Models of Seizures and Epilepsy, 1st Edition

Models of Seizures and Epilepsy, 1st Edition,Asla Pitkänen,Philip Schwartzkroin,Solomon Moshé,ISBN9780120885541

Pitkänen   &   Schwartzkroin   &   Moshé   

Academic Press




279 X 216

Models of Seizures and Epilepsy speaks to the needs of both basic neuroscientists and clinical neurologists, in understanding the pathophysiology of seizures and the epilepsies and predicting the clinical effectiveness of antiepileptic treatments.

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Key Features

· The first comprehensive description of animal models of epilepsy since the early 1970's

· Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer

· Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research

· World expert opinions on the clinical relevance of each model


An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research.


Neurologists, epileptologists, developmental neuroscientists, medical geneticists, molecular/developmental biologists.

Asla Pitkänen

Affiliations and Expertise

A.I.Virtanen Institute, University of Kuopio, Kuopio, Finland

Philip Schwartzkroin

Affiliations and Expertise

University of California, Davis, USA

View additional works by Philip A. Schwartzkroin

Solomon Moshé


Dr. Moshé is a professor of neurology, neuroscience, and pediatrics at Albert Einstein College of Medicine. He is the Director of Child Neurology and Clinical Neurophysiology and the recipient of a Martin A. and Emily L. Fisher fellowship in Neurology and Pediatrics at Albert Einstein. Dr. Moshé received his M.D. from the National University of Athens School of Medicine, Athens, Greece in 1972. He trained in pediatrics at the University of Maryland and in neurology at Albert Einstein. Since 1979, his research has focused on understanding the mechanisms underlying age-related differences in epilepsy in humans and in animal models. During the last ten years, his interest has turned to elucidating the subcortical circuitry involved in the control of seizures as a function of age and the consequences of seizures on the developing brain.

Affiliations and Expertise

Albert Einstein College of Medicine, Bronx, New York, U.S.A. Professor of Neurology, Albert Einstein College of Medicine, New York; Department of Neurology, Montefiore Medical Center, Bronx, NY

Quotes and reviews

"This book is an invaluable resource for those interested in the details of epilepsy. It will be an excellent resource for all neurologists and neurosurgeons involved in research or clinical treatment for the disease."

"5 Stars - This is a superb and current compendium of selected models of epilepsy and their utility in investigating the various mechanisms and manifestations of epilepsy. ...This book should be on the shelf as a resource for all investigators of the mechanisms of epilepsy whether they utilize cells, slices, mice, humans, or machines. It fills an important void in the review literature that has not been comprehensively addressed for some time."
--Gregory Kent Bergery, Johns Hopkins University School of Medicine, in DOODY'S (May 2006)

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