Toxicology of Organophosphate and Carbamate Compounds

Toxicology of Organophosphate and Carbamate Compounds, 1st Edition

Toxicology of Organophosphate and Carbamate Compounds, 1st Edition,Ramesh C. Gupta,ISBN9780120885237

R Gupta   

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Key Features

  • Describes everything you need to know about Organophosphates and Carbamates
  • Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants
  • Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates
  • Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases
  • Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity
  • Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis
  • Provides in vitro and in vivo models for neurotoxicity testing
  • Integrates knowledge of studies in lab animals and humans
  • Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues
  • Describes management of Anticholinesterase poisoning in humans


This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs.

In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.


Toxicologists, Pharmacologists, Biologists/Neurochemists, Physicians, and Libraries

Ramesh C. Gupta

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer(s) disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including six major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, and (6) Biomarkers in Toxicology. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Affiliations and Expertise

DVM, MVSc, PhD, DABT, FACT, FACN, FATS, Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

View additional works by Ramesh C. Gupta

Toxicology of Organophosphate and Carbamate Compounds, 1st Edition

Section-I Uses, Abuses & Epidemiology
1. Introduction
2. Classification and Uses of Organophosphates and Carbamates
3. Therapeutic Uses of Cholinesterase Inhibitors in Neurodegenerative Diseases
4. Co-administration of Memantine with Acetylcholinesterase Inhibitors: Preclinical and Clinical Evidence
5. Cholinesterase Inhibitors as Chemical Warfare Agents: Community Preparedness Guidelines
6. Organophosphates and the Gulf War Syndrome
7. The Bhopal Accident and Methyl Isocyanate Toxicity
8. Global Epidemiology of Organophosphates and Carbamates Poisonings

Section-II Pharmacokinetics & Metabolism
9. Physiologically Based Pharmacokinetic Modeling of Organophosphorus and Carbamate Pesticides
10. Metabolism of Organophosphorus and Carbamate Pesticides
11. Interspecies Variation in Toxicity of Cholinesterase inhibitors

Section-III Esterases, Receptors, Mechanisms & Tolerance Development
12. Structure and Function of Cholinesterases
13. Cholinesterase Pharmacogenetics
14. Methods for Measuring Cholinesterase Activities in Human Blood
15. Interactions of Organophosphorus and Carbamate Compounds with Cholinesterases
16. Structure, Function and Regulation of Carboxylesterases
17. Non-Cholinesterase Mechanisms of Central and Peripheral Neurotoxicity: Muscarinic Receptors and Other Targets
18. Paraoxonase (PON1) Polymorphisms and Toxicity of Organophosphates
19. Tolerance Development to Toxicity of Cholinesterase Inhibitors

Section-IV Organ Toxicity
20. CNS Effects and Neurotoxicity
21. Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos
22. In Vitro Models for Testing Organophosphate-Induced Neurotoxicity and Remediation
23. Electrophysiological Mechanisms in Neurotoxicity of Organophosphates and Carbamates
24. Behavioral Toxicity of Cholinesterase Inhibitors
25. PNS Effects and Delayed Neuropathy
26. The Intermediate Syndrome in Organophosphate Poisoning
27. Cardiovascular Toxicity of Cholinesterase Inhibitors
28. Pulmonary Toxicity of Cholinesterase Inhibitors
29. Approaches in Defining and Evaluating the Inhalation Pharmacology and Toxicology Hazards of Anticholinesterases
30. Dermal Absorption/Toxicity of Organophosphates and Carbamates
31. Local and Systemic Ophthalmic Pharmacology and Toxicology of Organophosphate and Carbamate Anticholinesterases
32. Reproductive Toxicity of Organophosphate and Carbamate Pesticides
33. Placental Toxicity of Organophosphate and Carbamate Pesticides
34. Endocrine Disruption by Organophosphate and Carbamate Pesticides
35. Organophosphates, Carbamates and the Immune System

Section-V Non-Specific Toxic Effects
36. Oxidative Stress in Anticholinesterase Induced Excitotoxicity
37. DNA Damage, Gene Expression and Carcinogenesis by Organophosphates and Carbamates
38. Temperature Regulation in Experimental Mammals and Humans Exposed to Organophosphate and Carbamate Agents
39. Occupational Toxicology and Occupational Hygiene Aspects of Organophosphate and Carbamate Anticholinesterases with Particular Reference to Pesticides

Section-VI Risk Assessment & Regulations

40. Public Health Impacts of Organophosphates and Carbamates
41. Cumulative Effects of Organophosphorus or Carbamate Pesticides
42. Federal Regulations and Risk Assessment of Organophosphate and Carbamate Pesticides
43. Regulatory Considerations in Developmental Neurotoxicity of Organophosphorus and Carbamate Pesticides
44. WHO/FAO Guidelines for Cholinesterase Inhibiting Pesticide Residues in Food

Section-VII Aquatic & Wildlife

45. Aquatic Toxicity of Carbamates and Organophosphates
46. Toxicity of Organophosphorus and Carbamate Insecticides Using Birds as Sentinels for Terrestrial Vertebrate Wildlife

Section-VIII Analytical & Biomarkers

47. Analysis of Organophosphate and Carbamate Pesticides and Anticholinesterase Therapeutic Agents
48. Biomarkers of Organophosphate Exposure

Section-IX Therapeutic Measures

49. Management of Organophosphorus Pesticide Poisoning

Quotes and reviews

"This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. ...The efforts of both editor and authors are highly praiseworthy because the text of the volume has been well organized giving appropriate tables, figures in depth and comprehensive manner, covering important and novel issues. Thus the volume provides a thorough knowledge in the field of OP and CMs and will be immensely useful not only to scientists and teachers but also an excellent addition to the libraries and research professionals in government, industry, regulators, decision makers and students who want to specialize in this field of specialization." -- Prof P.K.Gupta, Adviser to WHO and Director TCS Inc., Bareilly, India for TOXICOLOGY INTERNATIONAL (June 2006)
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