Seldin and Giebisch's The Kidney

Seldin and Giebisch's The Kidney, 5th Edition

Physiology & Pathophysiology

Seldin and Giebisch's The Kidney, 5th Edition,Robert Alpern,Michael Caplan,Orson Moe,ISBN9780123814623

Alpern   &   Caplan   &   Moe   

Academic Press




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A classic nephrology 2-volume reference for over 20 years.

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Key Features

  • Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters.
  • Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. 
  • Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions.


A classic nephrology reference for over 25years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information.


Academic and medical librarians in kidney physiology, nephrology and renal medicine. This will also serve as an excellent reference for clinical nephrologists and trainees, graduate students, researchers, academic clinicians and any pharmaceutical company working on renal medications.

Robert Alpern

Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor.

Affiliations and Expertise

Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Michael Caplan

Dr. Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in Autosomal Dominant Polycystic Kidney Disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. Following postdoctoral work in the Department of Cellular and Molecular Physiology at Yale, Caplan joined that department as a faculty member. He is currently the C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology.

Affiliations and Expertise

C.N.H. Long Professor and Chair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA

Orson Moe

Dr. Moe received his medical degree from the University of Toronto where he also did his internal medicine residency and clinical nephrology fellowship. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and is a member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Orson Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology.

Affiliations and Expertise

Professor of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Seldin and Giebisch's The Kidney, 5th Edition

Section 1: Epithelial and Nonepithelial Transport and Regulation

1 Epithelial Cell Structure and Polarity

Michael Caplan

2 Mechanisms of Ion Transport Across Cell Membranes & Epithelia

Luis Reuss and Guillermo Altenberg

3 Renal Ion-Translocating AT Phases: The P-Type Family

Eric Feraille

4 Mechanisms of Water Transport Across Cell Membranes & Epithelia

Luis Reuss and Guillermo Altenberg

5 Cell Volume Control

Florian Lang

6 Soute Transport, Energy Consumption, and Production in the Kidney

Hitoshi Endou and Takashi Sekine

7 Electrophysiological Analysis of Transepithelial Transport

Lawrence G. Palmer and Henry Sackin

8 Ion Channels and Electro-physiological Properties of Transport

James Stockand

9 Exchange of Fluid and Solutes Across Microvascular Walls

C. Charles Michel

10 External Balance of Electrolytes and Acids and Alkali

Man S. Oh

11 Cilium

Bradley Yoder

12 Inter-cellular Junctions

Alan S. L. Yu, Jano Peti-Perterdi, Fiona Hanner

13 Principles of Cell Signaling

Lloyd Cantley

14 Scaffolding Proteins in Transport Regulation

Paul A. Welling

15 The Renin-Angiotensin System

Thomas M. Coffman

16 Neural Control of Renal Function

Ulla C. Kopp and EJ Johns

17 Eicosanoids and the Kidney

Matthew Breyer, Raymond C. Harris, Richard M. Breyer

18 Extracellular Nucleotides and Renal Function

Robert J. Unwin and David Shirley

19 Paracrine Regulation of Renal Function by Dopamine

Pedro Jose

Section 2: Structural and Functional Organization of the Kidney

20 Structural Organization of the Mammalian Kidney

Wilhelm Kriz and Brigitte Kaissling

21 Biophysical Basis of Glomerular Filtration

Roland C. Blantz and Scott Thomson

22 Glomerular Structure and Cell Biology

Susan Quaggin

23 Function of the Juxtaglomerular Apparatus

Jurgen Schnermann and Hayo Castrop

24 Renal Cortical & Medullary Microcirculations

Thomas L. Pallone

25 Molecular and Cellular Mechanisms of Kidney Development

Sanjay K. Nigam and Kevin T. Bush

26 Molecular and Cellular Mechanisms of Glomerular Capilary Development

Jeffrey H. Miner and Dale R. Abrahamson

27 Postnatal Renal Development

Michael Baum

28 Renal Hyperplasia and Hypertrophy

Stuart J. Shankland

29 Stem Cells

Qais Al-Awqati and Juan Oliver

Section 3: Fluid and Electrolyte Regulation and Dysregulation

30 Epithelial Na+ Channels

Thomas R. Kleyman

31 Anion Channels

William B. Guggino

32 NaCL Co-transporters

Gerardo Gamba

33 Sodium and Chlorid Transport

Alan M. Weinstein

34 Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct Gerardo Gamba and Laurent Schild

35 Mineralocorticoid Action in the Aldosterone-Sensitive Distal Nephron

Johannes Loffing and Oliver Staub

36 Inherited Disorders of Renal Salt Homeostasis: Insights From Molecular Genetics Studies

Rick Lifton

37 Natriuretic Hormones

David L. Vesely

38 Physiology & Pathophysiology of Sodium Retention and Wastage

Biff F. Palmer, Donald W. Seldin and Robert J. Alpern

39 Physiology of Hypertension

John E. Hall

40 Physiology & Pathophysiology of Diuretic Action

David H. Ellison

41 Aquaporin Water Channels in Mammalian Kidney

Soren Nielsen

42 Thirst and Vasopressin

Gary L. Robertson

43 The Urine Concentrating Mechanism and Urea Transporters

Jeff M. Sands and Harold Layton

44 Hyponatremia

Richard H. Sterns

45 Hypernatremic States

Laurence Chan and Chris Rivard

46 Polyuria and Diabetes Insipidus

Daniel G. Bichet

47 The Molecular Biology of Renal Potassium Channels

Wenhui Wang and Chou Long Huang

48 Extrarenal Potassium Metabolism

Robert M. Rosa

49 Regulation of Potassium Excretion

Gerhard Giebisch and Lisa Satlin

50 Potassium Deficiency

Giovambattista Capasso, Miriam Zacchia and Francesco Trepiccione

51 Clinical Disorders of Hyperkalemia

Mitchell Halperin and Kamel

52 Control of Intracellular pH

Walter F. Boron and Mark Bevensee

53 Sodium-Coupled Bicarbonate Transporters

Ira Kurtz

54 The SLC4 Anion Exchanger Gene Family

Seth Alper

55 Cellular Mechanisms of Renal Tubular Acidification

Patricia Preisig, L. Lee Hamm and Robert Alpern

56 Chemoreceptors, Breathing, and pH

Eugene Nattie

57 Renal Ammonium Ion Production and Excretion

Norman P. Curthoys

58 Clinical Syndromes of Metabolic Alkalosis

Orson Moe, Robert J. Alpern and Donald W. Seldin

59 Clinical Syndromes of Metabolic Acidosis

Reto Krapf, Donald W. Seldin and Robert J. Alpern

60 Respiratory Alkalosis and Acidosis

Horacio J Adrogue and Nicolaos Madias

61 Mechanisms and Disorders of Magnesium Metabolism

Karl P. Schlingmann and Martin Konrad

62 Calcium Channels

René J.M. Bindels and Joost Hoenderop

63 The Calcium-Sensing Receptor

Edward Brown

64 Renal Calcium Metabolism

Peter A. Friedman and Jose Bernardo

65 The Hormonal Regulation of Calcium Metabolism

Rajiv Kumar

66 Disorders of Calcium Metabolism

John Wysolmerski and Cristina Dumitru

67 Pathogenesis and Treatment of Nephrolithiasis

Fredric L. Coe, Elaine Worcester and Andrew Evan

68 Proximal Tubular Handling of Phosphate

Heini Murer, Jurg Biber, Nati Hernando, and Ian Forster

69 Clinical Disturbances of Phosphate Homeostasis

Rajiv Kumar

70 Glucose Reabsorption in the Kidney

Ernest M. Wright

71 Amino Acids, Oligopeptides, and Hyperaminoacidurias

Francois Verrey, Simone R. Camargo, Victoria Makrides, Robert Kleta

72 Organic Anion and Cation Transporters in Renal Elimination of Drugs

Gerhard Burckhardt and Herman Koepsell

73 Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria

Erik I. Christensen, Rikke Nielsen, Henrik Birn

Section 4: Pathophysiology of Renal Disease

74 Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders Daniel Batlle

75 Biomarkers of Assessment of Renal Function (AKI/CKD)

Prasad Devarajan

76 Pathophysiology of Acute Kidney Injury

Bruce A Molitoris and Asif Sharfuddin

77 Ischemic Renal Disease

William L. Henrich, Lance Dworkin, and Christopher Cooper

78 Pathophysiology and Pathogenesis of Diabetic Nephropathy

Fuad N. Ziyadeh

79 Renal Failure in Cirrhosis

Robert W. Schrier and Pere Gines

80 Autosomal Dominant Polycystic Kidney Disease and Inherited Cystic Diseases

Stefan Somlo

81 Renal Physiology and Disease in Pregnancy

Ananth Karunmanchi

82 Immune-Mediated and Other Glomerular Diseases

John R. Sedor and Mike Madaio

83 Immunologic Mechanisms of Vasculitis

J. Charles Jennette, Jonathan Homeister, Ronald J. Falk

84 Genetic Abnormalities in Glomerular Function

Clifford E Kashtan and Yoav Segal

85 Cellular Mechanisms of Drug Nephrotoxicity

Zoltán Huba Endre and Robert Walker

86 Role of Glomerular Pressure in Progression

Roberto Zatz

87 Role of Protinuria in Progression

Giuseppe Remuzzi

88 The Inflammatory Response to Ischemic Acute Renal Injury

Christopher Y. Lu

89 Oxidants in Progressive Kidney Disease

Sudhir Vithalbhai Shah

90 Chronic Kidney Disease

William E. Mitch

91 Mineral Metabolism and Bone

L. Darryl Quarles

92 Hematopoiesis and the Kidney

Armin Kurtz

93 Electrolyte Disturbances in Dialysis

Biff Palmer

94 Homeostasis of Solute and Water by the Transplanted Kidney

J. Harold Helderman

95 Disposition and Dose Requirements of Drugs in renal Insufficiency

D. Craig Brater, Kathleen Giacomini, Claire Weiss, Par Matsson

Quotes and reviews

"This is a useful resource for both clinical and research nephrologists…it…provides an interesting read if a thorough understanding of a physiological or pathophysiological process affecting the kidney is needed. I would definitely recommend this book to anyone in the nephrology community, whether clinical or research oriented." Rating: 3 Stars--Doody.com, April 18, 2014
"Ninety-five chapters are arranged across the two volumes under four broad themes: epithelial and nonepithelial transport and regulation; structural and functional organization of the kidney; fluid and electrolyte regulation and dysregulation; and pathophysiology of renal disease."--Reference and Research Book News, August 2013

Praise for the Previous Edition:
"This is an excellent in-depth compilation of all aspects of renal physiology in health and disease, presented in well-balanced in chapters with high-quality figures and ample references…This book clearly represents an excellent, useful, usable, and (in view of recent rapid scientific progress) needed update of the previous edition and will have a prominent place on my bookshelf as well as those of many others in the field." - 4 Stars!-- Jens W. Goebel, MD, University of Kentucky, for Doody’s Review

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