Molecular Biology of B Cells, 1st Edition

Description

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

Readership

Research level immunologists, molecular biologists and geneticists

Molecular Biology of B Cells, 1st Edition

ORGANIZATION, REARRANGEMENT AND TRANSCRIPTION OF IMMUNOGLOBULIN GENES
Human Immunoglobulin heavy chains locus
Immunoglobulin heavy chain genes of mouse
Immunoglobulin ? genes of human and mouse
Immunoglobulin lambdav (IGL) genes of human and mouse
The Mechanism of V(D) J Recombination
Transcription of Immunoglobulin genes

B CELLS AND THEIR DEVELOPMENT
Early B cell development to a mature , antigen-sensitive cell - cellular stages and molecular decisions
Allelic exclusion, Isotypic exclusion and the Developmental Regulation of V(D)J Recombination
The Development of Human B Lymphocytes
Development and function of B cell subsets

B CELL DIFFERENTIATION INDUCED BY Ag STIMULATION
Structure and function of B cells antigen receptor complexes
Regulation of antigen receptor signaling by the co-receptors, CD19 and CD22
The dynamic structure of antibody responses
Dynamics of B cell migration to and within secondary lymphoid organs
Characteristics of mucosal B cells with emphasis on the human secretory immune system
The Cellular Basis of B Cell Memory
Immunoglobulin assembly and secretion
Fc And Complement Receptors

Ig GENE ALTERATION IN PERIPHERY
Regulation of Class Switch Recombination
Molecular Mechanism of Class Switch Recombination
Molecular Mechanism of Hypermutation
Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody

DISEASES OF B CELLS
Chromosomal Translocations in B-cell Leukemias and Lymphomas
Classification and Characteristics of Mouse B Cell-Lineage Lymphomas
B cells producing pathogenic autoantibodies
Immunodeficiencies Caused by B Cell Defects

EVOLUTION OF Ig GENES
Diverse forms of Immunoglobulin Genes in Lower Vertebrates
Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT
The zebrafish immune system
The Origin of V(D)J Diversification

FUNCTION AND APPLICATION OF IMMUNOGLOBULINS
Antibody Structure and Recognition of Antigen
Monoclonal antibodies from display libraries
Humanization of Monoclonal Antibodies
Human monoclonal antibodies from translocus mice