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Antioxidants in Disease Mechanisms and Therapy
 
 

Antioxidants in Disease Mechanisms and Therapy, 1st Edition

Antioxidants in Disease Mechanisms and Therapeutic Strategies

 
Antioxidants in Disease Mechanisms and Therapy, 1st Edition,J. August,Ferid Murad,M. Anders,Joseph Coyle,Lester Packer,ISBN9780080581309
 
 
 

August   &   Murad   &   Anders   &   Coyle   &   Packer   

Academic Press

9780080581309

707

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USD 249.00
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Key Features

@introbul:Key Features
@bul:* Contains cutting-edge information on focused topics written by expert scientists
* Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines
* Attempts molecular pathophysiology which links basic science and the clinic
* Presents critical assessment of controversial topics

Description

Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.

Readership

Students and researchers in pharmacology, biochemistry, and other biomedical disciplines. Academic neurologists, neuroscientists, and immunologists.

J. August

Affiliations and Expertise

John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.

View additional works by J. Thomas August

Ferid Murad

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Affiliations and Expertise

University of Texas Medical School, Houston, U.S.A.

View additional works by Ferid Murad

M. Anders

Affiliations and Expertise

University of Rochester; Department of Pharmacology, New York, U.S.A.

View additional works by M. W. Anders

Joseph Coyle

Affiliations and Expertise

McLean Hospital, Harvard Medical School, Belmont, Massachusetts, U.S.A.

View additional works by Joseph T. Coyle

Lester Packer

Affiliations and Expertise

Department of Molecular Pharmacology and Toxicology, School of Pharmaceutical Sciences, University of Southern California, USA

View additional works by Lester Packer

Antioxidants in Disease Mechanisms and Therapy, 1st Edition

Natural Antioxidants:
B. Halliwell, Antioxidants: The Basics--What They are and How to Evaluate Them.
A.M. Bode, Metabolism of Vitamin C in Health and Disease.
M.G. Traber, Regulation of Human Plasma Vitamin E.
M.E. Anderson, Glutathione and Glutathione Delivery Compounds.
L. Packer, S. Roy, and C.K. Sen, a-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription.
R.J. Reiter, Antioxidant Actions and Melatonin.
E. Lovaas, Antioxidative and Metal Chelating Effects of Polyamines.
L.G. Korkina and I.B. Afanas'ev, Antioxidant and Chelating Properties of Flavonoids.
Synthetic Antioxidants and Enzyme Mimics:
J.-B. Galey, Potential Use of Iron Chelators Against Oxidative Damage.
I.A. Cotgreave, N-Acetylcysteine: Pharmacological Considerations, Experimental and Clinical Applications.
H. Sies and H. Masumoto, Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite.
S.R. Doctrow, K. Huffman, C.B. Marcus, W. Musleh, A. Bruce, M. Baudry, and B. Malfroy, Salen Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy.
Antioxidant Enzyme Induction and Pathophysiology: A.C. Allison, Antioxidant Drug Targeting.
T. Primiano, T.R. Sutter, and T.W. Kensier, Antioxidant-Inducible Genes.
G. Powis, J.R. Gasdaska, and A. Baker, Redox Signaling and the Control of Cell Growth and Death.
R.A. Floyd, Protective Action of Nitrone Based Free Radical Traps Against Oxidative Damage to the Central Nervous System.
J.B. de Haan, E.J. Wolvetang, F. Cristiano, R. Iannello, C. Bladier, M.J. Kelner, and I. Kola, Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome.
P.G. Winyard and D.R. Blake, Antioxidants Redox-Regulated Transciption Factor and Inflammation.
Disease Processes:
H. Esterbauer, R. Schmidt, and M. Hayn, Relationships between Oxidation of LDL, Antioxidant Protection and Atherosclerosis.
S. Louie, B. Halliwell, and C.E. Cross, Adult Respiratory Distress Syndrome: A Radical Perspective.
A. van der Vliet, J.P. Eiserich, G.P. Marelich, B. Halliwell, and C.E. Cross, Oxidative Stress in Cystic Fibrosis: Does It Occur and Does It Matter?
A. Taylor and T. Nowell, Oxidative Stress and Antioxidant Function in Relation To Risk for Cataract.
J.T. Landrum, R.A. Bone, and M.D. Kilburn, The Macular Pigment: A Possible Role in Protection from Age-Related Macular Degeneration.
D.P.R. Muller, Neurological Disease.
W. Dröge, A. Grob, V. Hack, R. Kinscherf, M. Schykowski, M. Bockstette, S. Mihm, and D. Galter, Role of Cysteine and Glutathione in HIV Infection and Cancer Cachexia-Therapeutic Intervention with N-Acetyl-Cysteine.
C.S. Lieber, Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Disease.
B. Heller, V. Burkart, E. Lampeter, and H. Kolb, Antioxidant Therapy for the Prevention of Type I Diabetes.
K. Scharfetter-Kochanek, Photoaging of the Connective Tissue of the Skin, Its Prevention and Therapy.
S. Taylor, Antioxidant Nutrients and Cancer Incidence and Mortality: An Epidemiologic Perspective.
Chapter References.
Subject Index.

Quotes and reviews

@from:Praise for the Serial
@qu:"Recommended not only to pharmacologists but also to all those in related disciplines."
@source:--NATURE
@qu:"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."
@source:--H.E. Kaufmann in CHEMOTHERAPY
@qu:"Superb reading material."
@source:--JOURNAL OF PHARMACEUTICAL SCIENCES
@from:Praise for the Volume
@qu:"...a must in the library of researchers in the area of free radical biology... it presents an invaluable indepth critical coverage of topics inherent in the 'antioxidant literature' and ranging from basic physical chemistry concepts to clinical therapy, prevention, and epidemiological perspectives... an excellent book, highly recommended, on topics of great current interest."
@source:--Enrique Cadenas for FREE RADICAL RESEARCH
@qu:"Comprehensive, concise, well-referenced and original, this book also includes appropriate illustrations to explain the text... This book covers the complete spectrum of the topics dealing with molecular actions of natural and synthetic antioxidants and their potential role in disease states and therapeutic strategies."
@source:--Arshad Rahman, PhD, Rush Medical College of Rush University for DOODY'S PUBLISHING REVIEWS
@qu:"Comprehensive, concise, well-referenced and original, this book also includes appropriate illustrations to explain the text. The layout is simple and appealing... Weighted numerical score: 90 - 4 stars!"
@source:--Arshad Rahman in DOODY PUBLISHING
 
 
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