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Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds
 
 

Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds, 1st Edition

 
Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds, 1st Edition,J. August,Ferid Murad,M. Anders,Wolfgang Dekant,ISBN9780120329274
 
 
 

Advances in Pharmacology

August   &   Murad   &   Anders   &   Dekant   

Academic Press

9780120329274

9780080581187

519

229 X 152

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Key Features

@introbul:Key Features
@bul:* Summarizes the most recent information on:
* Xenobiotic conjugation
* Drug toxicity, hypersensitivity, and targeting
Chemical carcinogenesis
* Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
* Bioactivation and bioconversion

Description

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.

Readership

Researchers in biochemistry, bioorganic chemistry, medicinal and pharmaceutical chemistry, pharmacology, and toxicology.

J. August

Affiliations and Expertise

John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.

View additional works by J. Thomas August

Ferid Murad

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Affiliations and Expertise

University of Texas Medical School, Houston, U.S.A.

View additional works by Ferid Murad

M. Anders

Affiliations and Expertise

University of Rochester; Department of Pharmacology, New York, U.S.A.

View additional works by M. W. Anders

Wolfgang Dekant

Affiliations and Expertise

Universitat Wurzburg

Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds, 1st Edition

J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds.
Glutathione-Dependent Toxicity:
C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase.
B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases.
A.J.L. Cooper, Enzymology of Cysteine S-Conjugate b-Lyases.
W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway.
T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation.
T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites.
F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes.
R. Munday, Bioactivation of Thiols by One-Electron Oxidation.
N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals.
Sulfate Conjugate-Dependent Toxicity:
C.N. Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation.
C.J. Michejda and M.B.K. Koepke, Carcinogen Activation by Sulfate Conjugate Formation.
Glucuronide Conjugate-Dependent Toxicity:
K.W. Bock UDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens.
P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation of Glucuronide-Conjugate Formation. Bioactivation and Bioconversion:
P.E. Hanna, N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation.
M.W. Anders and W. Dekant, Aminoacylases.
J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation.
S. Vamvakas and M.W. Anders, Bioconversion of Prodrugs by Conjugate-Processing Enzymes.
Subject Index.

Quotes and reviews

@from:Praise for the Serial
@qu:"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading."
@source:--JOURNAL OF PHARMACEUTICAL SCIENCES
 
 
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