Biofilms and Implantable Medical Devices

Infection and Control

1st Edition - October 24, 2016
Editors: Ying Deng, Wei Lv
Language: English
Hardback ISBN:
9 7 8 - 0 - 0 8 - 1 0 0 3 8 2 - 4
eBook ISBN:
9 7 8 - 0 - 0 8 - 1 0 0 3 9 8 - 5

Biofilms and Implantable Medical Devices: Infection and Control explores the increasing use of permanent and semi-permanent implants and indwelling medical devices. As an understan… Read more

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Biofilms and Implantable Medical Devices: Infection and Control explores the increasing use of permanent and semi-permanent implants and indwelling medical devices. As an understanding of the growth and impact of biofilm formation on these medical devices and biomaterials is vital for protecting the health of the human host, this book provides readers with a comprehensive treatise on biofilms and their relationship with medical devices, also reporting on infections and associated strategies for prevention.

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List of contributors
Preface
Part One. Fundamentals and properties of biofilms
- 1. Overview of biofilm-related problems in medical devices
  - 1.1. Introduction
  - 1.2. Development of microbial biofilms on biomaterials used in medicine
  - 1.3. Incidence and etiology of biofilm-associated infections on medical devices
  - 1.4. The pathogenesis of infections associated with medical devices
  - 1.5. Strategies to prevent infections associated with medical devices
  - 1.6. Conclusion
- 2. Properties of biofilms developed on medical devices
  - 2.1. Introduction
  - 2.2. Biofilm infections related to medical devices
  - 2.3. Device-associated biofilms
  - 2.4. Conclusions
- 3. Adhesion of bacteria to surfaces and biofilm formation on medical devices
  - 3.1. Introduction
  - 3.2. Finding the target: bacterial motility and events that lead to bacterial contact with and attachment to a surface
  - 3.3. Coming and going versus staying put: adhesion to a surface, regulation of adhesion, and initiation of microcolony formation
  - 3.4. So it begins: reversible and irreversible attachment to a surface
  - 3.5. Growing old together: processes that lead to biofilm maturation
  - 3.6. Time to leave: biofilm dispersal and implications for the host
  - 3.7. There is a stranger in my house: mixed-species biofilms in relation to medical devices and human health
  - 3.8. Conclusions and thoughts moving forward
- 4. Antimicrobial resistance of biofilms in medical devices
  - 4.1. Introduction
  - 4.2. Biofilms—formation, structure, and resistance
  - 4.3. Infections associated with medical devices
  - 4.4. Biofilms in medical devices: resistance
  - 4.5. Conclusions
Part Two. Biofilm-related infections in medical devices
- 5. Biofilms on dental implants
  - 5.1. Introduction
  - 5.2. Oral implantology: fundamental principles
  - 5.3. Biofilms on dental implants
  - 5.4. Conclusions
- 6. Biofilm on bone repair devices
  - 6.1. Introduction
  - 6.2. Infection of bone repair devices
  - 6.3. Infection and bone allograft
  - 6.4. Influence of the synovial environment on infection
  - 6.5. Detection and treatment of orthopedic infection
  - 6.6. Conclusion
- 7. Prevention of biofilm formation by material modification
  - 7.1. Introduction
  - 7.2. Metals and alloys
  - 7.3. Polymers
  - 7.4. Ceramics
  - 7.5. Composite materials
  - 7.6. Conclusions and perspectives
- 8. Detection of bacterial adherence and biofilm formation on medical surfaces
  - 8.1. Introduction
  - 8.2. Diagnosis of device-associated biofilms
  - 8.3. Concluding remarks
- 9. Alternative strategies to reduce the incidence of severe infections
  - 9.1. Introduction
  - 9.2. Strategies based on natural modulators
  - 9.3. Strategies based on synthetic structures
  - 9.4. Conclusions
Index

Ying Deng

Dr. Ying Deng is an Associate Professor in the Department of Biomedical Engineering at the University of South Dakota (USD). Dr. Deng has authored or co-authored various articles in leading journals, exploring biomaterial applications, especially tissue engineering, and approaches to control biomaterial-related biofilm formation. She has co-authored a book chapter, patents, and has made dozens of presentations at national and international conferences. She has received research funding for multifunctional (biocompatible and antimicrobial) biomaterial development from the South Dakota Board of Regents (SDBOR), the United States Department of Defense, and the National Institutes of Health. In addition, she is currently serving as the Chair of the Sioux Valley Local Section of the American Chemical Society. Her research interests include the development of biocompatible and antimicrobial materials, tissue engineering, drug delivery systems, and surface modification and characterization of biomedical implants and devices.

Affiliations and expertise

Associate Professor, Department of Biomedical Engineering, University of South Dakota, USA

Wei Lv

Mr. Wei Lv is a graduate student in the Department of Biomedical Engineering at the University of South Dakota (USD). He received his Master’s degree in Biomedical Engineering from the University of South Dakota in 2012 and a Bachelor’s degree in Biotechnology from Heilongjiang University, China in 2009. He has around five years of experience in the development of antimicrobial technologies, including Chitosan, quaternary ammonium and N-halamines biomaterials, etc. His researches have been published in peer-reviewed journals, including Journal of Biomedical Materials Research Part A, Journal of Materials Science, and Biomaromolecules. His works have also been exhibited in a variety of national and international conferences. His current major research interests are focused on developing antimicrobial biomaterials for drug delivery, tissue engineering scaffolds and biomedical implants and devices. In addition, he has been invited to review manuscripts for leading journals, such as PLOS ONE and Nature Communications. He is a recipient of USD Research & Creative Activity Grants in 2014. He has been serving as a USD student chapter of the Society for Biomaterials committee member since 2010. Currently, He is the Chair for the USD student chapter of the Society for Biomaterials.

Affiliations and expertise

Department of Biomedical Engineering, University of South Dakota, USA