Bioscience and Bioengineering of Titanium Materials

Bioscience and Bioengineering of Titanium Materials, 2nd Edition

Bioscience and Bioengineering of Titanium Materials, 2nd Edition,Yoshiki Oshida,ISBN9780444626264






This updated, comprehensive publication reviews the latest findings and helps medical and dental practitioners understand when and how to use titanium in various biomaterials applications.

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Key Features

  • Provides quick access to the primary literature in this field
  • Up-to-date information on nanoscience and nanotechnology developments
  • Helps answer questions about the most appropriate materials to use and when to use them


The second edition of Bioscience and Bioengineering of Titanium Materials is an essential resource for anyone researching titanium in its fundamental aspects and in medical/dental applications. The book organizes and processes the findings from over 2,000 published articles and studies into a coherent and easily accessible volume, deftly weaving together older and newer technologies to give a clear overview. Bridging the gap between medical/dental and engineering/technology areas, the book covers material classification, fabrication and modification, as well as applications and biological reactions to titanium implants.

The author, with extensive work in academics and industry, helps medical practitioners and students answer many practical questions, including: What is titanium? What type of titanium materials should I use in this case? How can I fabricate my design using titanium? Are there any alternative materials or methods? In the second edition, macro-, micro-, and nano-texturing of titanium surfaces, tissue engineering-related materials including scaffolds, and functionally graded materials and structures are extensively included and analyzed.


Materials scientists, students, and engineers working in biomaterials research and applications.

Yoshiki Oshida

Affiliations and Expertise

Professor Emeritus, School of Dentistry, Indiana University, Bloomington, IN, USA Research Professor, College of Engineering, Syracuse University, Syracuse, NY, USA Adjunct Professor, School of Dentistry, University of California San Francisco, San Francisco, CA, USA

Bioscience and Bioengineering of Titanium Materials, 2nd Edition



Preface for the Second Edition

1. Introduction


2. Materials Classification

2.1. Introduction

2.2. General Classification

2.3. Medical/Dental Titanium Materials


3. Chemical and Electrochemical Reactions

3.1. Introduction

3.2. Discoloration

3.3. Corrosion in Media Containing Fluorine Ion and Bleaching Agents

3.4. Corrosion under Influences of Environmental and Mechanical Actions

3.5. Metal Ion Release and Dissolution

3.6. Galvanic Corrosion

3.7. Microbiology-Induced Corrosion

3.8. Reaction with Hydrogen


4. Oxidation and Oxides

4.1. Introduction

4.2. Formation of Titanium Oxides

4.3. Influences on Biological Processes

4.4. Crystal Structures of Titanium Oxides

4.5. Characterization of Oxides

4.6. Unique Applications of Titanium Oxide

4.7. Oxide Growth, Stability, and Breakdown

4.8. Reaction with Hydrogen Peroxide

4.9. Applications of Advanced Technologies


5. Mechanical and Tribological Behaviors

5.1. Introduction

5.2. Fatigue

5.3. Fretting

5.4. Fracture and Fracture Toughness

5.5. Biotribological Actions

5.6. Improvement for Antitribological Deterioration


6. Biological Reactions

6.1. Introduction

6.2. Toxicity

6.3. Cytocompatibility (Toxicity to Cells)

6.4. Allergic Reaction

6.5. Metabolism

6.6. Biocompatibility

6.7. Biomechanical Compatibility


7. Implant-Related Biological Reactions

7.1. Introduction

7.2. Bone Healing

7.3. Bone Grafting

7.4. Hemocompatibility

7.5. Cell Adhesion, Adsorption, Spreading, and Proliferation

7.6. Roughness and Cellular Response to Biomaterials

7.7. Cell Growth

7.8. Tissue Reaction and Bone Ingrowth

7.9. Osteointegration and Bone–Implant Interface

7.10. Some Adverse Factors for Loosening Implants

7.11. Nonmetallic Implants


8. Implant Application

8.1. Introduction

8.2. Intraoral Implants Versus Extraoral Implants

8.3. Clinical Reports

8.4. Surface and Interface Characterizations

8.5. Reactions in Chemical and Mechanical Environments

8.6. Reaction in Biological Environment

8.7. Surface Modification Effects


9. Other Applications

9.1. Introduction

9.2. Denture Bases

9.3. Crowns and Bridges, and Abutment

9.4. Clasps

9.5. Posts and Cores

9.6. Titanium Fiber and Oxide Powder as Reinforcement for Bone Cement

9.7. Sealer Material

9.8. Shape Memory Effect Dental Implant

9.9. Orthodontic Appliances

9.10. Endodontic Files and Reamers

9.11. Clamps and Staples

9.12. Stents

9.13. MRI Safety and Image Compatibility


10. Fabrication Technologies

10.1. Introduction

10.2. Casting

10.3. Machining

10.4. Electro-discharge Machining

10.5. CAD/CAM

10.6. Isothermal Forging

10.7. Superplastic Forming

10.8. DB and SPF/DB

10.9. Powder Metallurgy

10.10. Metal Injection Molding

10.11. Mechanical Alloying

10.12. Laser Processing

10.13. Friction Stir Welding

10.14. Soldering

10.15. Heat Treatment

10.16. Coating

10.17. Electrospinning

10.18. Electron Beam Melting

10.19. Additive Manufacturing


11. Surface Modifications

11.1. Introduction

11.2. Mechanical Modification

11.3. Chemical, Electrochemical, Thermal, and Physical Modifications

11.4. Coating

11.5. Collagen, Protein, and CHI Coating

11.6. Coloring


12. Advanced Materials, Technologies, and Processes

12.1. Introduction

12.2. Materials, Structures, and Processes

12.3. Functionally Graded Materials and Design Concept

12.4. Controlled Porosity/Foamed Structures

12.5. Near-Net Shape Forming

12.6. Nanotechnology—Materials and Structures

12.7. Hybridization and Multifunctionality

12.8. Bioengineering and Biomaterial-Integrated Implant System



Quotes and reviews

"Oshida…reviews published research in engineering and in medicine and dentistry, notes differences and similarities, and fills in the gaps when possible based on his 20 years of experience in each field…topics are chemical and electrochemical reactions; oxidation and oxides; mechanical and tribological behaviors; biological reactions; implant-related biological reactions; implant applications; other applications; fabrication technologies; surface modifications; and advanced materials, technologies, and processes."--Reference & Research Book News, December 2013

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