Molecular Diversity and Combinatorial Chemistry

Molecular Diversity and Combinatorial Chemistry, 1st Edition

Principles and Applications

Molecular Diversity and Combinatorial Chemistry, 1st Edition,Michael Pirrung,ISBN9780080445328


Elsevier Science



240 X 165

Print Book


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USD 93.95

Key Features

* Making the main concepts of the field of molecular diversity and combinatorial chemistry accessible to non-specialists
* written specifically for the advanced undergraduate student or graduate student
* This book is an excellent guide to the conceptual framework of the field.


The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.


For undergraduate and post gradate students, instructors and lecturers in the field of combinatorial chemistry.

Michael Pirrung

Affiliations and Expertise

University of California, Riverside, USA

Molecular Diversity and Combinatorial Chemistry, 1st Edition

Nature: The Original Combinatorial Chemist
Biopolymers constitute natural libraries

Selection and evolution

The expression of genetic information

Combinatorial assembly of antibody genes

Molecular solutions to combinatorial problems
Synthetic Peptide Libraries
Solid-phase peptide synthesis

Peptides on pins

Other iterative deconvolution strategies

Examples of split/couple/mix peptide libraries

Positional scanning

Supports, Linkers, and Reagents for Peptide


PEG-grafted supports

Coupling strategies
Supports and Linkers for Small Molecule Synthesis
New resins and linkers

Ring-forming cleavage

Encoded Combinatorial Chemistry
Directed Sorting
Unnatural Oligomers for Library Synthesis


Peptidyl phosphonates

Analytical Methods for Solid-phase Synthesis
Product identification

Gel-phase NMR

High-resolution magic angle spinning NMR

On-bead infrared spectroscopy

Mass spectrometry

Non-spectroscopic methods
Supported Solution-phase Synthesis
Polyethylene glycols


Fluorous synthesis
Solution-phase Parallel Synthesis
Scavenging resins

Ion-exchange resins

Supported reagents

Fluorous reagents

Solid-phase extraction

Gas-phase separation
Multi-component Reactions
Chemical Informatics, Diversity, and Library Design

Representative flowchart for a library design

Lipinski's Rules
Nucleic Acid Microarrays
Combinatorial Materials Chemistry
Combinatorial Catalyst Discovery
Peptides on Phage
Applications of phage display
Nucleic Acid Selection
Complex Combinatorial and Solid-phase Synthesis



The Big Picture

Quotes and reviews

@qu: "This book is ideal for an advanced student or any chemist who, not being directly involved in combinatorial chemistry, wishes to get a general idea about its principles and applications. In particular, I recommend this book to all academic teachers that give a course (at master or Ph.D. level) on combinatorial chemistry and to their students. I will certainly use it myself as a guidance for my own course on the subject."

@source: Prof. Luca Banfi, University of Genova, MOLECULAR DIVERSITY, 2005
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