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Molecular Diversity and Combinatorial Chemistry
 
 

Molecular Diversity and Combinatorial Chemistry, 1st Edition

Principles and Applications

 
Molecular Diversity and Combinatorial Chemistry, 1st Edition,Michael Pirrung,ISBN9780080445328
 
 
 

  

Elsevier Science

9780080445328

188

240 X 165

Print Book

Paperback

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USD 93.95
 
 

Key Features

* Making the main concepts of the field of molecular diversity and combinatorial chemistry accessible to non-specialists
* written specifically for the advanced undergraduate student or graduate student
* This book is an excellent guide to the conceptual framework of the field.

Description

The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.

Readership

For undergraduate and post gradate students, instructors and lecturers in the field of combinatorial chemistry.

Michael Pirrung

Michael Pirrung, Ph.D., was trained as a synthetic organic chemist at UT-Austin, UC-Berkeley, and Columbia University with eminent synthetic chemists Clayton Heathcock and Gilbert Stork. His independent career began in the 1980s at Stanford University and the biotech start-up company Affymax. In 1990, he joined Duke University where he founded and directed the Program in Biological Chemistry. In 2004, he joined the UC-Riverside Chemistry department as UC Presidential Chair, and in 2012 became Distinguished Professor. He has been a visiting professor at UC-Berkeley, Baylor College of Medicine, Oxford, UC-San Diego, UC-Irvine, and Caltech. He has trained over 100 graduate students and postdoctoral fellows. He has held Hertz, Sloan, and Guggenheim fellowships and a NSF Presidential Young Investigator Award. He has over 170 peer-reviewed publications, more than 40 US and international patents, and has authored six books. The scope of his research has been broad, including natural product total synthesis, photochemical methods development, mechanistic enzymology, rhodium carbenoid chemistry, microarrays, combinatorial chemistry, and medicinal chemistry. His current work emphasizes peptide chemistry. His microarray work has been particularly recognized, with the 1991 AAAS-Newcomb Cleveland Prize, the 1993 Intellectual Property Owners Distinguished Inventor Award, the 2004 Chemical Pioneer Award of the American Institute of Chemists, and the 2006 European Inventor of the Year (for small and medium-sized enterprises). His editorial board service includes Cell Chemical Biology and Journal of Combinatorial Chemistry. He has worked extensively with development-stage and Fortune 500 companies as a consultant or scientific advisory board member. He also has an active practice as an expert witness for litigation in nucleic acid diagnostics and generic drugs.

Affiliations and Expertise

University of California, Riverside, USA

Molecular Diversity and Combinatorial Chemistry, 1st Edition

Nature: The Original Combinatorial Chemist
Biopolymers constitute natural libraries

Selection and evolution

The expression of genetic information

Combinatorial assembly of antibody genes

Molecular solutions to combinatorial problems
Synthetic Peptide Libraries
Solid-phase peptide synthesis

Peptides on pins

Other iterative deconvolution strategies

Examples of split/couple/mix peptide libraries

Positional scanning

Epilogue
Supports, Linkers, and Reagents for Peptide
Synthesis

Polystyrenes

PEG-grafted supports

Coupling strategies
Supports and Linkers for Small Molecule Synthesis
New resins and linkers

Ring-forming cleavage

Loading
Encoded Combinatorial Chemistry
Directed Sorting
Unnatural Oligomers for Library Synthesis
Peptoids

Azatides

Peptidyl phosphonates

Oligoureas
Analytical Methods for Solid-phase Synthesis
Product identification

Gel-phase NMR

High-resolution magic angle spinning NMR

On-bead infrared spectroscopy

Mass spectrometry

Non-spectroscopic methods
Supported Solution-phase Synthesis
Polyethylene glycols

Dendrimers

Fluorous synthesis
Solution-phase Parallel Synthesis
Scavenging resins

Ion-exchange resins

Supported reagents

Fluorous reagents

Solid-phase extraction

Gas-phase separation
Multi-component Reactions
Chemical Informatics, Diversity, and Library Design
Strategies

Representative flowchart for a library design

Lipinski's Rules
Nucleic Acid Microarrays
Combinatorial Materials Chemistry
Combinatorial Catalyst Discovery
Peptides on Phage
Applications of phage display
Nucleic Acid Selection
Complex Combinatorial and Solid-phase Synthesis
Epibatidine

Mappicine

Dysidiolide

The Big Picture

Quotes and reviews

@qu: "This book is ideal for an advanced student or any chemist who, not being directly involved in combinatorial chemistry, wishes to get a general idea about its principles and applications. In particular, I recommend this book to all academic teachers that give a course (at master or Ph.D. level) on combinatorial chemistry and to their students. I will certainly use it myself as a guidance for my own course on the subject."

@source: Prof. Luca Banfi, University of Genova, MOLECULAR DIVERSITY, 2005
 
 
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