* includes exercises
* suitable for self-study
The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.
Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.
The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic.
This volume has been written with the advanced undergraduate and graduate student in mind.
Advanced undergraduate students or graduate students
Molecular Diversity and Combinatorial Chemistry, 1st Edition
Nature: The Original Combinatorial Chemist
Biopolymers constitute natural libraries
Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems Synthetic Peptide Libraries
Solid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples of split/couple/mix peptide libraries
Epilogue Supports, Linkers, and Reagents for Peptide
Coupling strategies Supports and Linkers for Small Molecule Synthesis
New resins and linkers
Loading Encoded Combinatorial ChemistryDirected Sorting Unnatural Oligomers for Library Synthesis
Oligoureas Analytical Methods for Solid-phase Synthesis
High-resolution magic angle spinning NMR
On-bead infrared spectroscopy
Non-spectroscopic methods Supported Solution-phase Synthesis
Fluorous synthesis Solution-phase Parallel Synthesis
Gas-phase separation Multi-component Reactions Chemical Informatics, Diversity, and Library Design
Representative flowchart for a library design
Lipinski's Rules Nucleic Acid Microarrays Combinatorial Materials Chemistry Combinatorial Catalyst Discovery Peptides on Phage
Applications of phage display Nucleic Acid Selection Complex Combinatorial and Solid-phase Synthesis
Dysidiolide The Big Picture