Molecular Diversity and Combinatorial Chemistry

Molecular Diversity and Combinatorial Chemistry, 1st Edition

Principles and Applications

Molecular Diversity and Combinatorial Chemistry, 1st Edition,Michael Pirrung,ISBN9780080444932


Elsevier Science



240 X 165

Print Book


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USD 270.00

Key Features

* concept-based
* includes exercises
* suitable for self-study


The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic.

This volume has been written with the advanced undergraduate and graduate student in mind.


Advanced undergraduate students or graduate students

Michael Pirrung

Affiliations and Expertise

University of California, Riverside, USA

Molecular Diversity and Combinatorial Chemistry, 1st Edition

Nature: The Original Combinatorial Chemist
Biopolymers constitute natural libraries

Selection and evolution

The expression of genetic information

Combinatorial assembly of antibody genes

Molecular solutions to combinatorial problems

Synthetic Peptide Libraries
Solid-phase peptide synthesis

Peptides on pins

Other iterative deconvolution strategies

Examples of split/couple/mix peptide libraries

Positional scanning


Supports, Linkers, and Reagents for Peptide


PEG-grafted supports

Coupling strategies

Supports and Linkers for Small Molecule Synthesis
New resins and linkers

Ring-forming cleavage


Encoded Combinatorial Chemistry
Directed Sorting
Unnatural Oligomers for Library Synthesis


Peptidyl phosphonates


Analytical Methods for Solid-phase Synthesis
Product identification

Gel-phase NMR

High-resolution magic angle spinning NMR

On-bead infrared spectroscopy

Mass spectrometry

Non-spectroscopic methods

Supported Solution-phase Synthesis
Polyethylene glycols


Fluorous synthesis

Solution-phase Parallel Synthesis
Scavenging resins

Ion-exchange resins

Supported reagents

Fluorous reagents

Solid-phase extraction

Gas-phase separation

Multi-component Reactions
Chemical Informatics, Diversity, and Library Design

Representative flowchart for a library design

Lipinski's Rules

Nucleic Acid Microarrays
Combinatorial Materials Chemistry
Combinatorial Catalyst Discovery
Peptides on Phage
Applications of phage display

Nucleic Acid Selection
Complex Combinatorial and Solid-phase Synthesis



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