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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease
1st Edition, Volume 36 - July 6, 2005
Editors: Edward Bittar, Philippe Frank, Michael Lisanti
Language: English
Hardback ISBN:9780444515001
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eBook ISBN:9780080458601
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Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they…Read more
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Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Cell biologists, pharmaceutical researchers, and graduate level and medical students
Section 1: Caveolae organization and role in lipid cholesterol metabolism. Lipid rafts and caveolae organization. Caveolae and the regulation of cellular cholesterol homeostasis. Section 2: Caveolae and the regulation of endocytosis. The Caveolae Internalization Machinery. Lipid raft mediated entry of bacteria into host cells. Section 3: Examples of the role of caveolins in cell signaling. The caveolin interaction with the endothelial nitric oxide synthase (eNOS). Caveolae and Estrogen Receptor Signaling. eNOS regulation by sphingosine 1-phosphate and caveolin. Insulin signaling and caveolae. Section 4: Caveolae and pathologies. Caveolin-3, Caveolae, and Hereditary Muscle Diseases. Caveolae and Caveolins in the Vascular System. Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.
No. of pages: 264
Language: English
Edition: 1
Volume: 36
Published: July 6, 2005
Imprint: Elsevier Science
Hardback ISBN: 9780444515001
eBook ISBN: 9780080458601
EB
Edward Bittar
Affiliations and expertise
Department of Physiology, University of Wisconsin Medical School, Madison, USA
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