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Bioinorganic Chemistry
A Survey
1st Edition - July 3, 2008
Author: Ei-Ichiro Ochiai
Language: English
Paperback ISBN:9780120887569
9 7 8 - 0 - 1 2 - 0 8 8 7 5 6 - 9
eBook ISBN:9780080886978
9 7 8 - 0 - 0 8 - 0 8 8 6 9 7 - 8
Written by a preeminent teacher and scientist in the field, Bioinorganic Chemistry provides specialists, students, and general readers with an understanding of the basic chemis…Read more
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Written by a preeminent teacher and scientist in the field, Bioinorganic Chemistry provides specialists, students, and general readers with an understanding of the basic chemistry of interactions of inorganic substances with biological systems at the molecular level. The author presents bioinorganic concepts in context and brings a distinct chemistry perspective to the subject.
Provides the streamlined coverage appropriate for one-semester courses or independent study, with all of the necessary but none of the excessive information
Prepares readers to move to the next level of study (whether they continue on in the field or transition to medicine/industry)
Presents concepts through extensive four-color visuals, appealing to a range of learning styles
Promotes critical thinking through open-ended questions throughout the narrative and at the end of each chapter
Lecturers and students studying bioinorganic chemistry in inorganic, natural-products chemistry, and biochemistry programs *
Chapt. 0. Basics of Bio/ecosystems and Biochemistry, and Other Basic Concepts
0.1.Biosphere (Ecosystem)
0.1.1. Components of the biosphere-Living organisms
0.1.2. Bodily structure of living organisms
0.2. Cells, the Basic Functional Units of Living Organisms
0.3. Basic Biochemicals Essential to Life
0.3.1. Carbohydrates
0.3.1.1. Monosasccharides
0.3.1.2. Polysaccharides and derivatives
0.3.2. Lipids
0.3.2.1. Fats and phospholipids
0.3.2.2. Steroids
0.3.3. Proteins and amino acids
0.3.3.1. Structures
0.3.3.2. Reactions – formation and hydrolysis of protein
0.3.4. Nucleotides, vitamins (coenzymes) and others
0.3.4.1. Coenzymes
0.3.4.2. Nucleotides
0.3.4.3. Other vitamins
0.3.4.4. Hormone, neurotransmitters and others
0.3.5. DNA/RNA (Polynucleotide)
0.3.5.1. Structures
0.3.5.2. Reactions
0.4. Types of Biochemical Reactions
0.4.1. Reactions of acid-base type
0.4.2. Reactions of oxidation-reduction type
0.4.2.1. The idea of oxidation state
0.4.2.2. The oxidation state of “C” in organic compounds and recognition of oxidation-reduction reactions
0.4.2.3. Other kinds of oxidation-reduction reactions
0.4.3. Free radical reactions
0.5. Transition State Theory of Reaction, and Enzyme Kinetics
0.5.1. Energy profile and transition state theory of reaction
0.5.2. Enzyme Kinetics
0.5.3. Enzyme reaction mechanism
Chapt. 1. Distribution of Elements
1.1. Distribution of Elements in Earth Crust/Sea Water/Organisms
1.2. The Engines to Drive the Biochemical Cycling of the Elements
1.3. The Geochemical Cycling of Elements – Contribution by Biosphere
1.4. Historical Change in the Biogeochemical Cycling of Elements
Chapt. 2. Biological Necessity for and the Behaviors of Inorganic Elements
2.1. Introduction
2.2..Inorganic Elements in Biological Systems
2.2.1. Inorganic elements involved at molecular level
2.2.2. Inorganic elements involved at cellular level
2.2.3. Inorganic elements involved at physiological level
2.2.4. Biological systems involved in the metabolism of inorganic elements
2.3. Why have Organisms Chosen Specific Elements for their Specific Needs Basic Rules
2.4. Behaviors of Inorganic Elements-1-Fundamentals of Coordination Chemistry
2.4.1. Coordination compounds or metal complexes
2.4.2. Ligand field theory-how the predominant structure is determined
2.4.3. Thermodynamic tendency to form coordination compounds
2.4.4. Chelate effects
2.4.5. Ligand substitution reactions
2.4.6. Oxidation-reduction and reduction potential
2.4.7. Kinetic factors including long-range electron transference
2.5. Behaviors of Inorganic Elements-2-Organometallic Chemistry
2.5.1. Metal carbonyls and 18 electron rule
2.5.2. Other organometallic compounds
2.5.3. Some special types of reactions involving organometallic compounds
Chapt. 3. How Do Enzymes Work?
3.1. Enzymatic Enhancement of Reaction Rate – General Considerations
3.1.1. “Transition state” theory
3.1.2. The “Dynamic” effects
3.1.3. A Composite theory
3.2. Metalloenzymes and Metal-Activated Enzymes/Proteins
Chapt. 4. Reactions of Acid-Base Type and Functions of Metal Cations
4.1. General Considerations
4.1.1. Different types (definitions) of acid-base
4.1.2. Enzymes catalyzing reactions of acid-base type
4.1.3. Acidity scale and acid character of metal cations – prominence of Zn(II) and Mg(II)
4.1.4. Kinetic factors
4.1.5. The enhancement of reaction by amino acid residues in protein