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Advances in Immunology
1st Edition, Volume 92 - November 6, 2006
Editor: Frederick W. Alt
Language: English
Hardback ISBN:9780123736369
9 7 8 - 0 - 1 2 - 3 7 3 6 3 6 - 9
eBook ISBN:9780080469157
9 7 8 - 0 - 0 8 - 0 4 6 9 1 5 - 7
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wi…Read more
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Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Immunologists and infectious disease specialists, cell biologists and hematologists
Contributors to Volume 92
Publisher Summary
Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
Abstract
1 Introduction
2 Immunological Alterations in SLE
3 Genetics of SLE Susceptibility in Humans
4 Murine Models of SLE
5 Modeling Disease Development
Avian Models with Spontaneous Autoimmune Diseases
Abstract
1 Introduction
2 Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders
3 The OS Chicken: Model for Human Hashimoto Disease
4 The UCD‐200 Line of Chickens: A Model for Human Systemic Sclerosis
5 The SL Chicken Model for Human Autoimmune Vitiligo
6 Conclusions and Outlook
Acknowledgments
Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
Abstract
1 Introduction
2 Phenotype of CD4+CD25+ nTreg Cells
3 Factors Regulating the Expansion and Specificity of nTreg Cells
4 Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells
5 Growth Factor–Mediated Control of nTreg Cell Development, Function, and Homeostasis
6 Control of Autoimmune Responses by nTreg Cells
7 Summary and Conclusions
Acknowledgments
BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation
Abstract
1 Overview of BTLA and HVEM Ligand Discovery
2 Structural Characterization of BTLA Bound to HVEM
3 Viral Modulators of the HVEM–BTLA Pathway
4 Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs
5 Mechanisms of the CD28 Family Inhibitory Receptors
6 Consequences of HVEM Ligation
7 BTLA and HVEM in Models of Disease
8 Conclusions
The Human T Cell Response to Melanoma Antigens
Abstract
1 Introduction
2 Melanoma Antigens
3 Measurement of Antigen‐Specific T Cell Responses
4 Naturally Acquired Tumor Antigen‐Specific T Cell Responses
5 Vaccine‐Induced T Cell Responses
6 Regulation of Tumor Antigen‐Specific T Cell Responses
7 Conclusions
Acknowledgments
Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions
Abstract
1 Host–Pathogen Interactions
2 Manipulation of the Host Response by Pathogens: Some General Considerations
3 Antigen Presentation
4 Class I MHC Antigen Presentation
5 Pathogen Recognition by CD8+ T Cells and NK Cells
6 Class II MHC Antigen Presentation
7 Ubiquitin‐Proteasome System
8 The Ubiquitin Conjugation Cascade
9 Ubiquitin Ligases
10 Ubiquitin Chains and Ubiquitin‐Like Modifiers (Ubls)
11 Deubiquitinating Enzymes
12 The Proteasome
13 ER Quality Control and Degradation
14 ERAD Substrate Recognition
15 ERAD E3 Ligases
16 Mammalian ERAD E3s
17 The Elusive Dislocon
18 Driving Dislocation and the Ub‐Binding Route to the Proteasome
19 Peptide N‐Glycanase
20 Viral Interference with Class I MHC Antigen Presentation
21 Human Cytomegalovirus
22 HCMV Interference with Class I MHC Antigen Presentation
23 Dislocation from the ER: HCMV US11 and US2
24 Signal Peptide Peptidase Is Required for Dislocation from the ER
25 SPP and Generation of HLA‐E Epitopes
26 SPP and Processing of the Hepatitis C Virus Core Protein
27 SPP and Calmodulin Signaling
28 SPP Peptide Peptidase and Development
29 SPP and ER Quality Control
30 Three Routes of Pathogen‐Mediated ER Protein Disposal
31 Pathogen Interference with Class II MHC Antigen Presentation
32 Inhibition of Recognition at the Surface of the APC
33 Class II MHC Downregulation from the Surface of the APC
34 CD4 Downregulation from the Surface of the CD4+ T Cell
35 Pathogen Manipulation of the Ubiquitin‐Proteasome System
36 Interference with Proteasomal Proteolysis
37 Control of Infection
38 Virus Budding
39 Bacterial Chromosome Integration
40 ISGylation and deISGylation
41 Control of Inflammation
42 Posttranscriptional Gene Silencing
43 Downregulation of Cell Surface Receptors by Pathogen‐Encoded E3s
44 Programmed Cell Death in Plants
45 Cytokine Responses
46 Pathogen‐Encoded DUBs
47 Conclusions and Future Directions
Acknowledgments
Index
Publisher Summary
Contents of Recent Volumes
No. of pages: 344
Language: English
Edition: 1
Volume: 92
Published: November 6, 2006
Imprint: Academic Press
Hardback ISBN: 9780123736369
eBook ISBN: 9780080469157
FA
Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA