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The Autoimmune Diseases
4th Edition - March 27, 2006
Editors: M. Eric Gershwin, George C. Tsokos
Language: English
Hardback ISBN:9780125959612
9 7 8 - 0 - 1 2 - 5 9 5 9 6 1 - 2
eBook ISBN:9780080454740
9 7 8 - 0 - 0 8 - 0 4 5 4 7 4 - 0
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened.…Read more
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Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.
New to This Edition: * Tissue-specific interventions to arrest or "cure" autoimmune disease * Bone marrow eradication and replacement * Both basic science and clinical medicine is covered * Boxed points to emphasize key features of each chapter
Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases
IMMUNOLOGIC BASIS OF AUTOIMMUNITY AUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITION STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITY GENERAL FEATURES OF THE AUTOIMMUNE DISEASES ANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITY MHC COMPLEX AND AUTOIMMUNITY T CELLS AND AUTOIMMUNITY ROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITY TOLERANCE AND AUTOIMMUNITY – T CELLS REGULATORY T CELLS PEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLS B CELLS AND AUTOIMMUNITY MEMORY B CELL DEVELOPMENT TOLERANCE AND AUTOIMMUNITY – B CELLS GENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITION APOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENS EFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXES FUNCTIONAL EFFECTS OF ANTIBODIES ADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES SIGNALING PATHWAYS IN T AND B LYMPHOCYTES GENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASES GENETICS AND AUTOIMMUNITY - NON-MHC INFECTIONS, IMMUNITY AND AUTOIMMUNITY NON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITY VACCINES AND AUTOIMMUNE DISEASES SEX, PREGNANCY AND AUTOIMMUNITY
MULTISYSTEM DISEASES ANIMAL MODELS FOR AUTOIMMUNE DISEASE SYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS, AND MIXED CONNECTIVE TISSUE DISEASE THE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC SCLEROSIS- SCLERODERMA ANTIPHOSPHOLIPID SYNDROME SJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS) RHEUM ATOID ARTHRITIS SPONDYLOARTHRITIS AND CHRONIC IDIOPATHIC ARTHROPATHIES POLYMYOSITIS AND DERMATOMYOSITIS*
ENDOCRINE AND RELATED DISEASES THYROID DISEASE TYPE 1 DIABETES ADRENALITIS POLYENDOCRINE SYNDROMES AUTOIMMUNE GASTRITIS AND PERNICIOUS ANEMIA AUTOIMMUNE HYPOPHYSITIS
NEUROLOGIC DISEASES MULTIPLE SCLEROSIS PERIPHERAL NEUROPATHIES MYASTHENIA GRAVIS AND ANTI-RECEPTOR DISEASES OF THE NERVOUS SYSTEM UVEITIS INNER EAR DISEASE
CUTANEOUS DISEASES BULLOUS SKIN DISEASES: PEMPHIGUS VULGARIS AND OTHER TYPES OF PEMPHIGUS NON-BULLOUS SKIN DISEASES: ALOPECIA, PSORIASIS, VITILIGO, URTICARIA
UROGENITAL DISEASES KIDNEY: GOODPASTURE’S DISEASE, LUPUS NEPHRITIS, ANCA-ASSOCIATED GLOMERULONEPHRITIS AUTOIMMUNE ORCHITIS AND MALE INFERTILITY OOPHORITIS
CARDIOVASCULAR AND PULMONARY DISEASES RHEUMATIC HEART DISEASE MYOCARDITIS AND DILATED CARDIOMYOPATHY ATHEROSCLEROSIS: AUTOIMMUNITY TO HEAT-SHOCK PROTEINS NECROTIZING ARTERITIS AND SMALL VESSEL VASCULITIS VASCULITIS IDIOPATHIC BRONCHIOLITIS OBLITERANS, IDIOPATHIC PULMONARY FIBROSIS, AND THE AUTOIMMUNE DISORDERS OF THE LUNG
NEOPLASIA AND AUTOIMMUNITY PARANEOPLASTIC DISEASES – AUTOIMMUNE RESPONSES TO TUMOR ANTIGENS LYMPHOMA AND AUTOIMMUNE DISEASE APOPTOSIS AND AUTOIMMUNITY - LYMPHOPROLIFERATIVE SYNDROMES
MISCELLANEOUS CAMEOS
DIAGNOSIS, PREVENTION, AND THERAPY AUTOANTIBODY ASSAYS, TESTING AND STANDARDIZATION T-CELL ASSAYS PREDICTION OF AUTOIMMUNE DISEASE THE PREVENTION OF AUTOIMMUNE DISEASE: TYPE 1 DIABETES AS A PARADIGM EMERGING THERAPIES IN AUTOIMMUNE DISEASES EPILOGUE - ADVOCATUS DIABOLI
No. of pages: 1160
Language: English
Edition: 4
Published: March 27, 2006
Imprint: Academic Press
Hardback ISBN: 9780125959612
eBook ISBN: 9780080454740
MG
M. Eric Gershwin
M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease.
Affiliations and expertise
Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine and Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA
GT
George C. Tsokos
George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.
Affiliations and expertise
Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center