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Principles of Nucleic Acid Structure
1st Edition - October 15, 2007
Author: Stephen Neidle
Language: English
Paperback ISBN:9780123695079
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eBook ISBN:9780080553528
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This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion…Read more
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This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.
Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA)
Includes a complete list of resources, including relevant online databases and software
Defines technical lingo for novices
Researchers in biochemistry, as well as for advanced undergraduate and graduate students studying nucleic acid structure and function.
Methods for Studying Nucleic Acid Structure. The building-blocks of DNA and RNA. DNA Structure as Observed in Fibres and Crystals. DNA-DNA recognition: non-standard and higher-order DNA structures. Principles of small molecule-DNA Recognition. The RNA structural world. Principles of Protein-DNA Recognition.
No. of pages: 302
Language: English
Edition: 1
Published: October 15, 2007
Imprint: Academic Press
Paperback ISBN: 9780123695079
eBook ISBN: 9780080553528
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Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.
Affiliations and expertise
Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK
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