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Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

  • 1st Edition, Volume 47 - April 23, 1999
  • Editors: Dale J. Benos, Douglas M. Fambrough
  • Language: English
  • Paperback ISBN:
    9 7 8 - 0 - 1 2 - 0 8 9 0 3 0 - 9
  • eBook ISBN:
    9 7 8 - 0 - 0 8 - 0 5 8 5 1 8 - 5

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium… Read more

Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

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Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.