Wound Healing Biomaterials - Volume 2

Functional Biomaterials

1st Edition - May 30, 2016
Editor: Magnus Ågren
Language: English
Hardback ISBN:
9 7 8 - 1 - 7 8 2 4 2 - 4 5 6 - 7
eBook ISBN:
9 7 8 - 0 - 0 8 - 1 0 0 6 0 6 - 1

Wound Healing Biomaterials: Volume Two, Functional Biomaterials discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex a… Read more

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Wound Healing Biomaterials: Volume Two, Functional Biomaterials
discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal wounds opening up a new area of research in biomaterials and the ways they can be applied to the challenges associated with wound care.

Much research is now concerned with new therapies, regeneration methods, and the use of biomaterials that can assist in wound healing and alter healing responses. This book provides readers with a thorough review of the functional biomaterials used for wound healing, with chapters discussing the fundamentals of wound healing biomaterials, films for wound healing applications, polymer-based dressing for wound healing applications, and functional dressings for wound care.

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List of contributors
Woodhead Publishing Series in Biomaterials
Part One. Fundamentals of wound healing biomaterials
- 1. Introduction to biomaterials for wound healing
  - 1.1. Definition of biomaterial
  - 1.2. Types of biomaterials
  - 1.3. Wound healing
  - 1.4. Biomaterials used for dermal wound healing
  - 1.5. Polysaccharide-based biomaterial
  - 1.6. Protein-based biomaterial
  - 1.7. Nanofiber-based biomaterial
  - 1.8. Marine biomaterial
  - 1.9. Biomaterials with antimicrobial activity
  - 1.10. Biomaterials used for corneal wound healing
  - 1.11. Trends of biomaterials used for wound healing
  - 1.12. Limitations of biomaterials for wound healing applications
  - 1.13. Conclusions
- 2. Modelling of cell–tissue interactions in skin
  - 2.1. Introduction
  - 2.2. Brief overview of cutaneous wound healing
  - 2.3. Foreign body response
  - 2.4. Modulating cell responses to biomaterials
  - 2.5. Biomaterials for wound healing
  - 2.6. Skin substitutes
  - 2.7. Other uses of skin substitutes
  - 2.8. Stem cells
  - 2.9. Conclusions
- 3. Biofilms in wounds and wound dressing
  - 3.1. Introduction
  - 3.2. Infectious disease: microbial biofilm and human health
  - 3.3. Basic microbiology of planktonic and biofilm bacteria
  - 3.4. Biofilms in wounds
  - 3.5. Biofilm-based wound care
  - 3.6. Wound healing biomaterials: features, function, and impact on microbial biofilms
  - 3.7. Topical antibiotic combination treatments based on DNA identification of bacteria
  - 3.8. Polymerase chain reaction and sequencing
  - 3.9. Biofilm debridement
  - 3.10. Discussion and future trends
- 4. The importance of preventing and controlling biofilm in wounds: Biofilm models and nanotechnology in antibiofilm approaches
  - 4.1. Antibiofilm approaches in wound care
  - 4.2. In vitro biofilm models for studying chronic wounds
  - 4.3. Nanotechnology and wound healing
  - 4.4. Futures directions and conclusion
- 5. Control and treatment of infected wounds
  - 5.1. Background
  - 5.2. Current treatment and prevention of wound infections
Part Two. Biomaterial films for wound healing
- 6. Multilayer films for reducing bleeding and infection
  - 6.1. Introduction
  - 6.2. Polyelectrolyte multilayered films
  - 6.3. Concluding remarks
  - 6.4. Future trends
- 7. Collagen-based formulations for wound healing applications
  - 7.1. Introduction
  - 7.2. Collagen for wound healing
  - 7.3. Species differences in physicochemical properties of collagen-based formulations
  - 7.4. Collagen-based formulations
  - 7.5. Future trends and new prospects
- 8. Cyanoacrylate tissue glues for cutaneous wound closure
  - 8.1. Wound closure and its history
  - 8.2. Competing methods for wound closure
  - 8.3. Cyanoacrylate tissue glues and their development for clinical practice
  - 8.4. Clinical trials
  - 8.5. Conclusions and future developments
Part Three. Polymer biomaterials and dressings for wound healing
- 9. Collagens in wound healing
  - 9.1. Introduction
  - 9.2. Collagen family overview
  - 9.3. Collagenopathies
  - 9.4. Collagens in the skin
  - 9.5. Collagens in physiological and pathological wound healing
  - 9.6. Collagenopathies and wound healing
  - 9.7. Collagen-based therapies
  - 9.8. Outlook
- 10. Microparticulate polymers and hydrogels for wound healing
  - 10.1. Introduction
  - 10.2. Wound management
  - 10.3. Hydrogel- and polymer-based dressings for wound healing
  - 10.4. Natural polymers for wound healing
  - 10.5. Synthetic polymers for wound healing
  - 10.6. Micro- and nanoparticulate delivery systems in wound healing
  - 10.7. Hydrogel/polymer-based wound healing dressings in the market
  - 10.8. Clinical trials and patents related to hydrogel/polymer-based wound dressings
  - 10.9. Accelerating wound healing with active agents: future therapeutic trends
  - 10.10. Advanced PolyHeal™ technology for wound healing
  - 10.11. Conclusion and future perspectives
  - List of abbreviations
- 11. Engineered hydrogel-based matrices for skin wound healing
  - 11.1. Introduction
  - 11.2. Hydrogels attractiveness and achievements in skin wound healing
  - 11.3. Enhanced processing hydrogels
  - 11.4. Spongy-like hydrogels as advanced matrices for skin wound healing
  - 11.5. Future trends
- 12. Exploring the role of polyurethane and polyvinyl alcohol foams in wound care
  - 12.1. Introduction
  - 12.2. Polyurethane foams
  - 12.3. Polyvinyl alcohol foams
  - 12.4. Foams for absorbent dressings
  - 12.5. Foams for negative pressure wound therapy
- 13. Biopolymers as wound healing materials
  - 13.1. Introduction
  - 13.2. Biopolymers as wound healing materials
  - 13.3. Proteins
  - 13.4. Conclusions and future perspectives
- 14. In situ–formed bioactive hydrogels for delivery of stem cells and biomolecules for wound healing
  - 14.1. Injectable hydrogels
  - 14.2. Stem cell therapy for wound healing
  - 14.3. In situ–formed bioactive hydrogels for wound healing
  - 14.4. Future direction
- 15. Polystyrene-based wound healing systems
  - 15.1. Background
  - 15.2. Polystyrene as a biomaterial
  - 15.3. Proposed future applications
  - 15.4. Conclusion
  - Abbreviations
- 16. Silver-doped hydrogels for wound dressings
  - 16.1. Overview of wound dressings
  - 16.2. Wound healing process
  - 16.3. Hydrogels
  - 16.4. Silver
  - 16.5. Mode of action of silver
  - 16.6. Clinical use of silver-doped hydrogels
  - 16.7. Side effects of silver use
  - 16.8. Regulatory Issues
  - 16.9. Future trends in silver-doped hydrogels
  - 16.10. Conclusions
  - Conflicts of interest
- 17. Keratins in wound healing
  - 17.1. Introduction
  - 17.2. Keratin as a biomaterial
  - 17.3. Activity of applied keratins in wound healing
  - 17.4. Clinical application of keratins in wound healing
  - 17.5. Keratins used in biomaterial research
  - 17.6. Conclusion
Part Four. Other functional biomaterial dressingsfor wound healing
- 18. Activated protein C to treat chronic wounds
  - 18.1. Introduction
  - 18.2. Activated protein C
  - 18.3. Mechanisms of action of APC in wound healing phases
  - 18.4. Patents on APC and wound healing
  - 18.5. APC in the treatment of chronic wounds
  - 18.6. Conclusion
  - 18.7. Commentary on likely future trends
- 19. Clay minerals for tissue regeneration, repair, and engineering
  - 19.1. Introduction
  - 19.2. Properties and use of clays in health care and therapeutic products
  - 19.3. Clay minerals and drug interactions
  - 19.4. Nanocomposites
  - 19.5. Clay minerals and hemostasis
  - 19.6. Clay minerals and cell interactions
  - 19.7. Clay mineral–based scaffolds
  - 19.8. Final remarks
- 20. Silver-containing dressings
  - 20.1. Introduction
  - 20.2. Bioburden, critical colonisation and biofilm and antibacterial therapies in wound management
  - 20.3. History of silver use in wound care
  - 20.4. Antimicrobial action of silver
  - 20.5. Silver dressings
  - 20.6. Indications for silver dressings in acute and chronic wound management
  - 20.7. Safety and the use of silver: systemic effects, absorption and argyria
  - 20.8. Clinical and health economic evidence for silver dressings
  - 20.9. Future of silver dressings
  - 20.10. Conclusions
- 21. Antibacterial effects of titanium dioxide in wounds
  - 21.1. Introduction
  - 21.2. Use of TiO2 against wound infections
  - 21.3. Future trends
- 22. Bioactive nanofiber dressings for wound healing
  - 22.1. Introduction
  - 22.2. Wound management and preparation
  - 22.3. Phases of wound healing and the healing cascade
  - 22.4. Biomaterials for wound healing
  - 22.5. Nanofiber dressing fabrication
  - 22.6. Drug and cell incorporation strategies
  - 22.7. Applications
  - 22.8. Conclusion
- 23. Nanofibrous smart bandages for wound care
  - 23.1. Advantages of nanofibers for wound healing applications
  - 23.2. Nanofiber manufacturing systems
  - 23.3. Polymers used to develop nanofibrous wound dressings
  - 23.4. Drug delivery to wound sites using medicated nanofibers
  - 23.5. Conclusions and future directions
Index

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Magnus Ågren