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Thermal Sensors
1st Edition, Volume 74 - October 27, 2014
Editors: León Islas, Feng Qin
Language: English
Hardback ISBN:9780128001813
9 7 8 - 0 - 1 2 - 8 0 0 1 8 1 - 3
eBook ISBN:9780128004487
9 7 8 - 0 - 1 2 - 8 0 0 4 4 8 - 7
Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist th…Read more
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Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading.
This volume presents an up to date presentation of current knowledge and problems in the field of thermal receptors. This is a rapidly evolving research area and the book contains important contributions from some of the leaders in the field.
Written by leading experts
Contains original material, both textual and illustrative, that should become a very relevant reference material
The material is presented in a very comprehensive manner
Both researchers in the field and general readers should find relevant and up-to-date information
Professionals working in the field and general physiologists seeking to brush up on the current state of the art in the field of thermal receptors.
Current Topics in Membranes, Volume 74
Preface
Previous Volumes in Series
Current Topics in Membranes and Transport
Current Topics in Membranes
Chapter One. Thermal Effects and Sensitivity of Biological Membranes
1. Introduction
2. Response of Organisms to Changes in Temperature
3. General Thermal Dependence of Membrane Properties
4. Pyroelectricity
5. Infra Red Radiation and Capacitance
6. Activation of Specific Channels by IR
7. Conclusions
Chapter Two. Temperature Sensing by Thermal TRP Channels: Thermodynamic Basis and Molecular Insights
1. Introduction
2. Principles of Temperature Activation
3. Temperature Dependence of Thermal TRP Channels
4. Kinetics and Energetics of Thermal Channels
5. Hysteresis of Temperature-Dependent Gating
6. Heat Capacity Theory
7. Origins of Thermal Sensitivity
8. Distribution of Thermal Sensitivity: Global or Local?
9. Identification of Molecular Basis of Thermal Sensitivity
10. Summary
Chapter Three. Gating of Thermally Activated Channels
1. Introduction
2. Temperature-Sensitive Channel Diversity
3. Energetics of Temperature-Sensitive Channels
4. Gating Kinetics in ThermoTRP Channels
5. Molecular Determinants of Temperature Sensing in TRP Channels
6. CODA
Chapter Four. TRPA1 Channels: Chemical and Temperature Sensitivity
1. Introduction
2. Activation and Regulation of TRPA1 by Chemical Compounds
3. Temperature Sensitivity of TRPA1
Chapter Five. Temperature Sensitivity of Two-Pore (K2P) Potassium Channels
1. Introduction
2. Physiological Role of Heat-Activated K2P Channels
3. Molecular Mechanism of Temperature Gating of TREK-1, TREK-2, and TRAAK
4. Heat- and Mechanosensitivity of K2Ps: Different Facets of the Same Process?
5. Future Studies of K2P Channel Thermal Sensitivity
Chapter Six. Lipid Modulation of Thermal Transient Receptor Potential Channels
1. Introduction
2. Phosphatidylinositol 4,5-Bisphosphate (PIP2)
3. GPCR Signaling Pathways
4. n-3 PUFAs and Derivatives
5. Oxidized Lipids
6. Lysophospholipids
7. Cholesterol and Steroids
8. Other Lipids
9. Concluding Remarks
Chapter Seven. Structure of Thermally Activated TRP Channels
1. Introduction
2. TRP Channels as Thermal Sensors
3. Outlook and Prospective
Chapter Eight. Thermal Sensitivity of CLC and TMEM16 Chloride Channels and Transporters
1. Introduction
2. Thermal Nociception
3. TMEM16A
4. CLC Proteins
5. Conclusions
Chapter Nine. Structure and Function of the ThermoTRP Channel Pore
1. Introduction
2. Structural Features of a ThermoTRP Channel Pore
3. Functional Tests of Pore Structures
4. Activation Gating of TRPV1
5. Pore Dilation
6. Concluding Remarks
Chapter Ten. Temperature-Sensitive Gating of Voltage-Gated Proton Channels
1. Introduction
2. Properties and Physiological Functions of Hv
3. Thermosensitive Functions of Cells Expressing Hv
4. Temperature Dependence of Native Hv
5. Molecular Structure of Hv1/VSOP
6. Thermal Stability of the Coiled-Coil Domain and the Thermal Sensitivity of Hv
7. Model of Thermosensitive Channel Gating
Chapter Eleven. Intimacies and Physiological Role of the Polymodal Cold-Sensitive Ion Channel TRPM8
1. Introduction
2. TRPM8, a Cold-Activated Polymodal Ion Channel
3. Physiological Role of TRPM8
4. Trafficking, N-glycosylation and Modulation of TRPM8 Channel Function