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Systems Biology in Toxicology and Environmental Health
1st Edition - June 11, 2015
Editor: Rebecca Fry
Language: English
Paperback ISBN:9780128015643
9 7 8 - 0 - 1 2 - 8 0 1 5 6 4 - 3
eBook ISBN:9780128015681
9 7 8 - 0 - 1 2 - 8 0 1 5 6 8 - 1
Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease…Read more
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Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants.
Systems Biology in Toxicology and Environmental Health
is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health.
Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology
Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology
Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them
Professional researchers and graduate and postgraduate students new to the fields of toxicology and environmental health.
Preface
Chapter 1. Systems Biology in Toxicology and Environmental Health
Systems Biology Defined
Technologies Utilized in Systems Biology
Applications of Systems Biology in Environmental Health
Applications of Systems Biology in Toxicology
Applications of Systems Biology in the Clinic
Summary
Chapter 2. The Cell: The Fundamental Unit in Systems Biology
Introduction
The Cell: Structure and Organelles
Cellular Signaling: Plasma Membrane and Signal Transduction
Cellular Homeostasis (I): Energy Metabolism
Decoding the Genome (I): Transcription
Decoding the Genome (II): Translation
Cellular Homeostasis (II): Cell Differentiation, Death
Chapter 3. Systems Biology and the Epigenome
Introduction
DNA Methylation
Molecular Basis of DNA Methylation
Posttranslational Histone Modifications
Chromatin
Chapter 4. Omics Technologies Used in Systems Biology
Introduction
Genomics
Generation of Microarray Data
Genomic Data Generation Using Whole Transcriptome Shotgun Sequencing (RNA-Seq)
Proteomics
Metabolomics
Summary
Chapter 5. Computational Methods Used in Systems Biology
Introduction
Study Design for Systems Biology
Genetics
Epigenomics
Transcriptomics
Proteomics
Metabolomics
Integration into a Systems Framework
Summary
Chapter 6. Priority Environmental Contaminants: Understanding Their Sources of Exposure, Biological Mechanisms, and Impacts on Health
Introduction
Top 10 Compounds from the ATSDR 2013 Priority List of Hazardous Substances
Carcinogenic, Organic Hazardous Air Pollutants
Environmental Contaminants of Emerging Concern
Conclusions
Chapter 7. Environmental Contaminants and the Immune System: A Systems Perspective
Introduction: What Is the Immune System?
Innate versus Adaptive or Acquired Immunity
Leukocytes: Cells of the Immune System
Cytokines, Chemokines, and Chemotaxis
How Is the Immune System Linked to Inflammation?
Signaling Pathways That Regulate the Immune System
IFNγ Regulation of Immune Function
TGFβ and Immune Function
NFκB Signaling and the Immune System
TNF Regulation of Immune Function
The Role of MAPK Proteins, JNK and p38 in the Immune Response
The Immune System and Disease States
Immunodeficiency Diseases
Autoimmune Diseases
Immune Function and Type 1 Diabetes
Environmental Exposures and Their Impact on Immune-Related Signaling Pathways
Arsenic and the Immune System
Cadmium Effects on the Immune System
Air Pollution and Immune Function
Mercury
Conclusions
Chapter 8. The Role of Apoptosis-Associated Pathways as Responders to Contaminants and in Disease Progression
Introduction to Apoptosis
Canonical Pathways that Regulate Apoptosis Initiation
Apoptosis Signaling Pathways and Disease
Apoptosis Pathways That Are Altered by Environmental Compounds
Conclusions
Chapter 9. Systems Biology of the DNA Damage Response
Introduction
DNA Damage and Its Responses
The Systems Biology Mantra
Mapping the DDR Network in Yeast
The Systems Biology of Human Cell Response to DNA Double-Strand Breaks
Comparison of Yeast and Human Systems of Response to DNA Damage
Chapter 10. Hormone Response Pathways as Responders to Environmental Contaminants and Their Roles in Disease
Introduction: Overview of the Endocrine System
Hormone Response Pathways
Health Effects of Hormone Pathway Dysregulation
Environmental Contaminants and Hormone Response Pathways
Conclusions
Chapter 11. Developmental Origins of Adult Disease: Impacts of Exposure to Environmental Toxicants
Introduction
Developmental Origins of Health and Disease: Adverse Environmental Conditions in Early Life and Latent Health Effects
Early-Life Toxicant Exposure: Latent Health Effects and Epigenetic Alterations
Conclusions and Future Directions
Index
No. of pages: 284
Language: English
Edition: 1
Published: June 11, 2015
Imprint: Academic Press
Paperback ISBN: 9780128015643
eBook ISBN: 9780128015681
RF
Rebecca Fry
Dr. Rebecca Fry is an Associate Professor in the Department of Environmental Sciences and Engineering at the Gillings School of Global Public Health at UNC-Chapel Hill. She also holds appointments in the Curriculum in Toxicology and the Lineberger Cancer Center. She is the Deputy Director of UNC’s Superfund Research Program funded by the National Institute of Environmental Health Sciences (NIEHS). She also serves as the Director of Graduate Studies in the Curriculum of Toxicology and Co-PI of an NIEHS-funded T32 training grant. Dr. Fry received her B.S. in Biology from William Smith College. She received her M.S. and Ph.D. in Biology from Tulane University and completed her post-doctoral training at MIT. Her research focuses on unraveling the biological mechanisms by which prenatal exposures to toxic metals impact infant health. A primary goal of Dr. Fry’s research is to increase awareness of the deleterious impacts of exposures during the prenatal period and to improve public health initiatives to address this issue.
Affiliations and expertise
Associate Professor, Environmental Sciences and Engineering, Gillings School of Global Public Helath, University of North Carolina Chapel HIll, Chapel HIll, NC, USA
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