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Synthesis of Essential Drugs

Synthesis of Essential Drugs, 1st Edition

Synthesis of Essential Drugs, 1st Edition,Ruben Vardanyan,Victor Hruby,ISBN9780444521668


Elsevier Science




240 X 165

An excellent handbook for chemists, scientists, students and professionals working in medicinal chemistry

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Key Features

* Provides a brief description of methods of synthesis, activity and implementation of all drug types
* Includes synonyms
* Includes over 2300 references


This book represents an effort to express a long overdue need of compiling information which has been accumulated over the course of more than 30 years of our work in the area of the synthesis of medicinal drugs. Our effort fills obvious gaps that exist in the literature of drug synthesis.

The synthesis of various groups of drugs are presented in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists.

Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed description of methods for their synthesis.

Of the thousands of drugs existing on the pharmaceutical market, we mainly discuss generic drugs that are included in the WHO’s "Essential List of Drugs."

For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms.

This book will provide the kind of information that will be of interest to those who work, or plan to begin work in the captivating areas of biologically active compounds and the synthesis of medicinal drugs.


Chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students

Ruben Vardanyan

Affiliations and Expertise

University of Arizona, Tucson, AZ, USA

Victor Hruby

Affiliations and Expertise

University of Arizona, Tucson, AZ, USA

Synthesis of Essential Drugs, 1st Edition

1. General Anesthetics

2. Local Anesthetics

3. Analgesics

4. Hypnotics and Sedatives

5. Anxiolitics (Tranquilizers)

6. Antipsycotics (Neuroleptics)

7. Antidepressants

8. Central Nervous System Stimulants

9. Antiepileptics

10. Anti-Parkinson Drugs

11. Adrenegic (Sympatomimetic) Drugs

12. Adrenoblocking Drugs

13. Cholinomimetics

14. Anticholinergic Drugs

15. Muscle Relaxants

16. Antihistamine Drugs

17. Cardiac Glycosides and Other Inotropes

18. Drugs for Tachyarrhytmias

19. Antianginal Drugs

20. Agents Used in Hyperlipoproteinemia

21. Diuretics

22. Antihypertensive Drugs

23. Drugs for Treating of Pulmonary Diseases

24. Anticoagulants, Antiagregants, Trombolytics and Hemostatics

25. Thyroid and Parathyroid Drugs

26. Insulin and Synthetic Hypoglycemic Agents

27. Corticosteroids

28. Female Sex Hormones

29. Male Sex Hormones and Anabolics

30. Antineoplastic Agents

31. Immunopharmacologic Drugs

32. Antibiotics

33. Antimicrobials

34. Antimicobacterials

35. Antifungal Drugs

36. Antiviral Drugs

37. Antiprotozoal Drugs

38. Antihelmint Drugs

Quotes and reviews

* Provides a brief description of methods of synthesis, activity and implementation of all drug types
* Includes synonyms
* Includes over 2300 references
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