Songtao Shi

Songtao Shi

Songtao Shi, D.D.S., Ph.D., is Professor at the University of Southern California Ostrow School of Dentistry. Dr. Shi received his D.D.S. degree and certificate in Pediatric Dentistry from the Peking University School of Stomatology and Ph.D. in Craniofacial Biology from the University of Southern California. Prior to joining the faculty at the University of Southern California, he served as a Principal Investigator and Clinical Fellow for nine years at the National Institute of Dental and Craniofacial Research. His research program focuses on understanding mechanism of mesenchymal stem cell (MSC)-associated diseases, developing new experimental disease models, and exploring feasibility of translating these bench discoveries to clinical therapies. His group and his collaborators were the first to identify dental pulp stem cells, baby tooth stem cells, periodontal ligament stem cells, root apical papilla stem cells, tendon stem cells, gingiva stem cells, sclera MSCs, and benign tumor MSCs from keloid and ossifying fibroma. In translational study, Dr. Shi’s team has used these stem cells to regenerate a variety of tissues, including dentin, pulp, periodontal ligament, tendon, bone, bio-root. Dr. Shi and his collaborators were the first to use MSCs to treat systemic lupus erythematosus (SLE), periodontitis, bisphosphonate-related osteonecrosis of the jaw-like disease (BRONJ) in animal models and patients. Additionally, Dr. Shi and his collaborators were the first to generate BRONJ, osteoradionecrosis, keloid, and ossifying fibroma diseases in mouse and swine models. To understand mechanisms of MSC-based therapies, Dr. Shi’s team revealed that MSC mediated bone regeneration was regulated by recipient T cell, which is the pioneer study showing association between cell-based tissue engineering and immune response. Additionally, Dr. Shi and his collaborators discovered that MSC-mediated immunotherapy in human and mouse model is associated the interplay between the donor cells and recipient T cells via Fas/FasL pathway. Recently, Dr. Shi’s team first time showed that MSCs contribute to orofacial benign tumor development via an epigenetic regulation network. Dr. Shi has published more than 150 peer-reviewed articles in a variety of high-impact scientific journals, of which he served as the corresponding author in Nat Medicine, Cell Stem Cell, Lancet, J Clin Invest, Nat Biotechnol, Proc Natl Acad Sci U S A, Cell Research, Blood, J Bone Miner Res, Stem Cells, PLoS ONE, and J Dent Res. Dr. Shi’s research is supported by NIH grants and funding from California Institute of Regenerative Medicine. Dr. Shi has served on several local and national committees and boards including Scientific Editor for the PLoS ONE and Associate Editor for Oral Diseases. He is recipient of the 2013 IADR Distinguished Scientist Award for Pulp Biology & Regeneration. He is on the editorial board of Stem Cell Research & Therapy, the editorial board of World Journal of Stem Cells, and the editorial board of Chinese Journal of Dental Research. Dr. Shi is Changjing Scholar in the Fourth Military Medical University, Distinguished Visiting Professor in Tongji University, Visiting Professor in XiangYa School of Medicine & Stomatology, Central South University (CSU), and distinguished visiting professor in Dankook University, Korea.

Affiliations and Expertise

School of Dentistry, University of Southern California, Los Angeles, USA